ABIRATERONE ACETATE



Abretone


Indication:

Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.


Abretone (Abiraterone acetate) is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.



Brand name: Abretone

Active Ingeridents:Abiraterone Acetate

Company Name: Cadila Pharmaceuticals

Package: 120 Tablets/bottle

Strength : 250 mg

Mechanism of action:


Abiraterone, the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).


Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Abretone (Abiraterone acetate)reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:


  • Abretone (Abiraterone acetate)is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • The amount of Abretone (Abiraterone acetate)you receive depends on many factors. Your doctor will determine your dose and schedule


Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.


Store:


Store Abretone (Abiraterone acetate)at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Abretone (Abiraterone acetate)out of the reach of children and away from pets.


Precaution:


Before starting Abretone (Abiraterone acetate) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.


Abretone (Abiraterone acetate)is currently not indicated for use in women. However, if Abretone (Abiraterone acetate)is given to a woman, getting pregnant should be avoided and the woman should not breast feed.






WARNING:


Abretone is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Xbira



Indication:

Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.


Xbira (Abiraterone Acetate) is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.



Brand name: Xbira

Active Ingeridents: Abiraterone Acetate

Company Name: Cipla

Package: 120 Tablets/bottle

Strength :250 mg

Mechanism of action:


Abiraterone, the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).


Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Xbira (Abiraterone Acetate) reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:


  • Xbira (Abiraterone Acetate) is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • The amount ofXbira (Abiraterone Acetate) you receive depends on many factors. Your doctor will determine your dose and schedule

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.


Store:


Store Xbira (Abiraterone Acetate) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Xbira (Abiraterone Acetate) out of the reach of children and away from pets.


Precaution:


Before starting Xbira (Abiraterone Acetate) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.


Xbira (Abiraterone Acetate) is currently not indicated for use in women. However, if Xbira (Abiraterone Acetate) is given to a woman, getting pregnant should be avoided and the woman should not breast feed.









WARNING:


Xbira is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Zecyte



Indication:

Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.


Zecyte (Abiraterone Acetate) is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.



Brand name: Zecyte

Active Ingeridents: Abiraterone Acetate

Company Name: Cipla

Package: 120 Tablets/bottle

Strength :250 mg

Mechanism of action:


Zecyte (Abiraterone Acetate), the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).


Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Zecyte (Abiraterone Acetate) reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:


  • Zecyte (Abiraterone Acetate)is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.


Store:


Store Zecyte (Abiraterone Acetate) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zecyte (Abiraterone Acetate) out of the reach of children and away from pets.


Precaution:


Before starting Zecyte (Abiraterone Acetate) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.


Zecyte (Abiraterone Acetate) is currently not indicated for use in women. However, if Zecyte (Abiraterone Acetate) is given to a woman, getting pregnant should be avoided and the woman should not breast feed.


WARNING:


Zecyte is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Zelgor



Indication:

Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.


Zelgor (Abiraterone acetate) is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.



Brand name: Zelgor

Active Ingeridents: Abiraterone Acetate

Company Name:Ranbaxy

Package: 120 Tablets/bottle

Strength :250 mg

Mechanism of action:


Zelgor (Abiraterone acetate),the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).


Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Zelgor (Abiraterone acetate) reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:


  • Zelgor (Abiraterone acetate) is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • The amount of Zelgor (Abiraterone acetate) you receive depends on many factors. Your doctor will determine your dose and schedule

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.


Store:


Store Zelgor (Abiraterone acetate) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zelgor (Abiraterone acetate) out of the reach of children and away from pets.


Precaution:


Before starting Zelgor (Abiraterone acetate) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.


Zelgor (Abiraterone acetate) is currently not indicated for use in women. However, if Zelgor (Abiraterone acetate) is given to a woman, getting pregnant should be avoided and the woman should not breast feed.


WARNING:


Zelgor is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Zybiraa



Indication:

Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.


Zybiraa (Abiraterone Acetate) is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.



Brand name: Zybiraa

Active Ingeridents: Abiraterone Acetate

Company Name: Zydus

Package: 120 Tablets/bottle

Strength :250 mg

Mechanism of action:


Zybiraa (Abiraterone Acetate), the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).


Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Zybiraa (Abiraterone Acetate) reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:


  • Zybiraa (Abiraterone Acetate) is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • The amount of Zybiraa (Abiraterone Acetate) you receive depends on many factors. Your doctor will determine your dose and schedule

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.


Store:


Store Zybiraa (Abiraterone Acetate) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zybiraa (Abiraterone Acetate) out of the reach of children and away from pets.


Precaution:


Before starting Zybiraa (Abiraterone Acetate) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.


Zybiraa (Abiraterone Acetate) is currently not indicated for use in women. However, if Zybiraa (Abiraterone Acetate) is given to a woman, getting pregnant should be avoided and the woman should not breast feed.


WARNING:


Zybiraa is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Zytiga



Indication:

Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.


Zytiga(Abiraterone Acetate) is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.



Brand name: Zytiga

Active Ingeridents: Abiraterone Acetate

Company Name: Janssen

Package: 120 Tablets/bottle

Strength :250 mg

Mechanism of action:


Zytiga (Abiraterone Acetate), the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).


Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Zytiga (Abiraterone Acetate) reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:


  • Zytiga (Abiraterone Acetate) is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • The amount of Zytiga (Abiraterone Acetate) you receive depends on many factors. Your doctor will determine your dose and schedule

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.


Store:


Store Zytiga (Abiraterone Acetate) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zytiga (Abiraterone Acetate) out of the reach of children and away from pets.


Precaution:


Before starting Zytiga (Abiraterone Acetate) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.


Zytiga (Abiraterone Acetate) is currently not indicated for use in women. However, if Zytiga (Abiraterone Acetate) is given to a woman, getting pregnant should be avoided and the woman should not breast feed.


WARNING:


Zytiga is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.