AZACITIDINE



Azacitidine


Indication:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.


Azacitidine is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.



Brand name: Azacitidine

Active Ingeridents:Azacitidine

Company Name: Dr.Reddy’s

Package: Vial

Strength : 100mg

Mechanism of action:


Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As Azacitidine is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.


Dosage and Administration:


Use Azacitidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Abretone (Abiraterone acetate)is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • The amount of Abretone (Abiraterone acetate)you receive depends on many factors. Your doctor will determine your dose and schedule

Warning:


Azacitidine is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.


Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.


Store:


Azacitidine is usually handled and stored by a health care provider. If you are using Azacitidine at home, store Azacitidine as directed by your pharmacist or health care provider. Keep Azacitidine out of the reach of children and away from pets.


Precaution:


Before starting Azacitidine treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).


Do not receive any kind of immunization or vaccination without your doctor's approval while taking Azacitidine.













Azacitidine



Indication:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.


Azacitidine is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.



Brand name: Azacitidine

Active Ingeridents: Azacitidine

Company Name: Azacitidine

Package: Vial

Strength : 100mg

Mechanism of action:


Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As Azacitidine is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.


Dosage and Administration:


Use Azacitidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Azacitidine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Azacitidine at home, a health care provider will teach you how to use it. Be sure you understand how to use Azacitidine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

  • Do not use Azacitidine if it contains particles, is discolored, or if the vial is cracked or damaged.

  • You may receive certain other medicines before Azacitidine to help decrease the risk of nausea and vomiting. Discuss any questions with your doctor.

  • Ask your health care provider any questions you may have about how to use Azacitidine.

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.


Store:


Azacitidine is usually handled and stored by a health care provider. If you are using Azacitidine at home, store Azacitidine as directed by your pharmacist or health care provider. Keep Azacitidine out of the reach of children and away from pets.


Precaution:


Before starting Azacitidine treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).


Do not receive any kind of immunization or vaccination without your doctor's approval while taking Azacitidine.









WARNING:


Azacitidine is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Vidaza



Indication:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.


Vidaza(Azacitidine) is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.



Brand name: Vidaza

Active Ingeridents: Azacitidine

Company Name: Pharmion Corporation

Package: Vial

Strength : 100 mg

Mechanism of action:


Vidaza(Azacitidine) (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Vidaza(Azacitidine) is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As Vidaza (Azacitidine) is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.


Dosage and Administration:


Use Vidaza (Azacitidine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Vidaza (Azacitidine) is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Vidaza (Azacitidine) at home, a health care provider will teach you how to use it. Be sure you understand how to use Vidaza (Azacitidine). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

  • Do not use Vidaza (Azacitidine) if it contains particles, is discolored, or if the vial is cracked or damaged.

  • You may receive certain other medicines before Vidaza (Azacitidine) to help decrease the risk of nausea and vomiting. Discuss any questions with your doctor.

  • Ask your health care provider any questions you may have about how to use Vidaza (Azacitidine).

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.


Store:


Vidaza (Azacitidine) is usually handled and stored by a health care provider. If you are using Vidaza (Azacitidine) at home, store Vidaza (Azacitidine) as directed by your pharmacist or health care provider. Keep Vidaza (Azacitidine) out of the reach of children and away from pets.


Precaution:


Before starting Vidaza (Azacitidine) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).


Do not receive any kind of immunization or vaccination without your doctor's approval while taking Vidaza (Azacitidine).


WARNING:


Azacitidine is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Xpreza



Indication:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.


Xpreza(Azacitidine) is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.



Brand name: Xpreza

Active Ingeridents: Azacitidine

Company Name: Natco

Package: Vial

Strength : 100mg

Mechanism of action:


Xpreza(Azacitidine) (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Xpreza(Azacitidine) is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As Xpreza (Azacitidine) is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.


Dosage and Administration:


Use Xpreza (Azacitidine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Xpreza (Azacitidine) is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Xpreza (Azacitidine) at home, a health care provider will teach you how to use it. Be sure you understand how to use Xpreza (Azacitidine). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

  • Do not use Xpreza (Azacitidine) if it contains particles, is discolored, or if the vial is cracked or damaged.

  • You may receive certain other medicines before Xpreza (Azacitidine) to help decrease the risk of nausea and vomiting. Discuss any questions with your doctor.

  • Ask your health care provider any questions you may have about how to use Xpreza (Azacitidine).

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.


Store:


Xpreza (Azacitidine) is usually handled and stored by a health care provider. If you are using Xpreza (Azacitidine) at home, store Xpreza (Azacitidine) as directed by your pharmacist or health care provider. Keep Xpreza (Azacitidine) out of the reach of children and away from pets.


Precaution:


Before starting Xpreza (Azacitidine) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).


Do not receive any kind of immunization or vaccination without your doctor's approval while taking Xpreza (Azacitidine).


WARNING:


Azacitidine is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Zybiraa



Indication:

Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.


Zybiraa (Abiraterone Acetate) is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.



Brand name: Zybiraa

Active Ingeridents: Abiraterone Acetate

Company Name: Zydus

Package: 120 Tablets/bottle

Strength :250 mg

Mechanism of action:


Zybiraa (Abiraterone Acetate), the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).


Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Zybiraa (Abiraterone Acetate) reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:


  • Zybiraa (Abiraterone Acetate) is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • The amount of Zybiraa (Abiraterone Acetate) you receive depends on many factors. Your doctor will determine your dose and schedule

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.


Store:


Store Zybiraa (Abiraterone Acetate) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zybiraa (Abiraterone Acetate) out of the reach of children and away from pets.


Precaution:


Before starting Zybiraa (Abiraterone Acetate) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.


Zybiraa (Abiraterone Acetate) is currently not indicated for use in women. However, if Zybiraa (Abiraterone Acetate) is given to a woman, getting pregnant should be avoided and the woman should not breast feed.


WARNING:


Zybiraa is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Zytiga



Indication:

Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.


Zytiga(Abiraterone Acetate) is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.



Brand name: Zytiga

Active Ingeridents: Abiraterone Acetate

Company Name: Janssen

Package: 120 Tablets/bottle

Strength :250 mg

Mechanism of action:


Zytiga (Abiraterone Acetate), the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).


Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).


Zytiga (Abiraterone Acetate) reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:


  • Zytiga (Abiraterone Acetate) is a tablet, taken by mouth. It is taken once a day.

  • It must be taken on an empty stomach [2 hours after a meal, or one hour before]

  • It should be taken at approximately the same time each day.

  • Prednisone [10mg daily] should be taken along with abiraterone acetate.

  • The amount of Zytiga (Abiraterone Acetate) you receive depends on many factors. Your doctor will determine your dose and schedule

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.


Store:


Store Zytiga (Abiraterone Acetate) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zytiga (Abiraterone Acetate) out of the reach of children and away from pets.


Precaution:


Before starting Zytiga (Abiraterone Acetate) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.


Zytiga (Abiraterone Acetate) is currently not indicated for use in women. However, if Zytiga (Abiraterone Acetate) is given to a woman, getting pregnant should be avoided and the woman should not breast feed.


WARNING:


Zytiga is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.