BEVACIZUMAB



Avastin


Indication:


It is used in the treatment of metastatic colon or rectal cancer, non-squamous, non-small cell lung cancer, metastatic breast cancer, glioblastoma (GBM), metastatic renal cell carcinoma.



Brand name:Avastin

Active Ingeridents:Bevacizumab

Company Name:Genentech

Package: Vial

Strength :400 mg

Mechanism of action:


Avastin (Bevacizumab) contains human framework regions with antigen binding regions of a humanised murine antibody that binds to VEGF. Avastin (Bevacizumab) is produced by recombinant DNA technology in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and is purified by a process that includes specific viral inactivation and removal steps. Avastin (Bevacizumab) binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This prevents blood vessel proliferation and in response retardation of metastatic tumor growth occurs.


Dosage and Administration:


Use Avastin (Bevacizumab) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Avastin (Bevacizumab) solution is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.

Ask your health care provider any questions you may have about how to use Avastin (Bevacizumab) solution.

Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; changes in taste; constipation; diarrhea; dizziness; dry mouth; dry skin; headache; increased thirst; indigestion; loss of appetite; minor nosebleeds; muscle pain; nausea; pain, swelling, or redness at the injection site; stuffy or runny nose; tiredness; voice changes; vomiting; weakness; weight loss.


Store:


Avastin (Bevacizumab) solution is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.


Precaution:


  • Before starting Avastin (Bevacizumab) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.

  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Avastin (Bevacizumab).

WARNING:


Avastin is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.




Avastin



Indication:


It is used in the treatment of metastatic colon or rectal cancer, non-squamous, non-small cell lung cancer, metastatic breast cancer, glioblastoma (GBM), metastatic renal cell carcinoma.



Brand name: Avastin

Active Ingeridents: Bevacizumab

Company Name: Genentech

Package:Vial

Strength :100 mg

Mechanism of action:


Avastin (Bevacizumab) contains human framework regions with antigen binding regions of a humanised murine antibody that binds to VEGF. Avastin (Bevacizumab) is produced by recombinant DNA technology in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and is purified by a process that includes specific viral inactivation and removal steps. Avastin (Bevacizumab) binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This prevents blood vessel proliferation and in response retardation of metastatic tumor growth occurs.


Dosage and Administration:


Use Avastin (Bevacizumab) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Avastin (Bevacizumab) solution is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.

If you miss a dose of Avastin (Bevacizumab) solution, contact your doctor immediately to establish a new dosing schedule.

Ask your health care provider any questions you may have about how to use Avastin (Bevacizumab) solution.


Store:


Avastin (Bevacizumab) solution is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.


Side effects:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; changes in taste; constipation; diarrhea; dizziness; dry mouth; dry skin; headache; increased thirst; indigestion; loss of appetite; minor nosebleeds; muscle pain; nausea; pain, swelling, or redness at the injection site; stuffy or runny nose; tiredness; voice changes; vomiting; weakness; weight loss.


Precaution:


  • Before starting Avastin (Bevacizumab) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Avastin (Bevacizumab).

WARNING:


Avastin is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.