BORTEZOMIB



Bortenat



Indication:


Bortenat (Bortezomib) is used to treat multiple myeloma and mantle cell lymphoma.


Bortenat (Bortezomib) is sometimes given after other cancer medications have been tried without successful treatment.




Brand name:Bortenat

Active Ingeridents: Bortezomib

Company Name: Natco Pharma

Package: 1 vial

Strength : 2 mg

Mechanism of action:


Bortenat (Bortezomib) is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The active site of the proteasome has chymotrypsin-like, trypsin-like, and postglutamyl peptide hydrolysis activity. The 26S proteasome degrades various proteins critical to cancer cell survival, such as cyclins, tumor suppressors, BCL-2, and cyclin-dependent kinase inhibitors. Inhibition of these degradations sensitizes cells to apoptosis. Bortenat (Bortezomib) is a potent inhibitor of 26S proteasome, which sensitizes activity in dividing multiple myeloma and leukemic cells, thus inducing apoptosis.


Dosage and Administration:


Use Bortenat (Bortezomib) as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Drinking extra fluids while you are taking Bortenat (Bortezomib) is recommended. Check with your doctor for instructions.

  • Bortenat (Bortezomib) is given as an injection into a vein or under the skin at your doctor's office, hospital, or clinic. Bortenat (Bortezomib) is not intended to be injected into the spinal cord. Contact your health care provider if you have any questions.

  • It is very important that each dose is given at the scheduled time. If you miss a dose of Bortenat (Bortezomib), contact your doctor right away to establish a new dosing schedule. Do not use 2 doses at once.

  • Ask your health care provider any questions you may have about how to use Bortenat (Bortezomib).

Side effects:


Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Constipation; diarrhea; dizziness; headache; loss of appetite; mild stomach pain; nausea; stomach upset; taste changes; tiredness; trouble sleeping; vomiting; weakness.


Store:


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing .Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.


Precaution:



  • Before starting Bortenat (Bortezomib) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.

  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Bortenat (Bortezomib).

WARNING:


Bortenat is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Bortecad



Indication:


Bortecad (Bortezomib) is used to treat multiple myeloma and mantle cell lymphoma.


Bortecad (Bortezomib) is sometimes given after other cancer medications have been tried without successful treatment.



Brand name: Bortecad

Active Ingeridents:Bortezomib

Company Name: Cadila

Package: 1 vial

Strength :2 mg

Mechanism of action:


Bortecad (Bortezomib) is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The active site of the proteasome has chymotrypsin-like, trypsin-like, and postglutamyl peptide hydrolysis activity. The 26S proteasome degrades various proteins critical to cancer cell survival, such as cyclins, tumor suppressors, BCL-2, and cyclin-dependent kinase inhibitors. Inhibition of these degradations sensitizes cells to apoptosis. Bortecad (Bortezomib) is a potent inhibitor of 26S proteasome, which sensitizes activity in dividing multiple myeloma and leukemic cells, thus inducing apoptosis.


Dosage and Administration:


Use Bortecad (Bortezomib) as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Drinking extra fluids while you are taking Bortecad (Bortezomib) is recommended. Check with your doctor for instructions.

  • Bortecad (Bortezomib) is given as an injection into a vein or under the skin at your doctor's office, hospital, or clinic. Bortecad (Bortezomib) is not intended to be injected into the spinal cord. Contact your health care provider if you have any questions.

  • It is very important that each dose is given at the scheduled time. If you miss a dose of Bortecad (Bortezomib), contact your doctor right away to establish a new dosing schedule. Do not use 2 doses at once.

  • Ask your health care provider any questions you may have about how to use Bortecad (Bortezomib).

Side effects:


Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Constipation; diarrhea; dizziness; headache; loss of appetite; mild stomach pain; nausea; stomach upset; taste changes; tiredness; trouble sleeping; vomiting; weakness.


Store:


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing .Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.


Precaution:


  • Before starting Bortecad (Bortezomib) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Bortecad (Bortezomib).

WARNING:


Bortecad is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Myezom



Myezom (Bortezomib) is used to treat multiple myeloma and mantle cell lymphoma.


Myezom (Bortezomib) is sometimes given after other cancer medications have been tried without successful treatment.



Brand name: Myezom

Active Ingeridents:Bortezomib

Company Name: Dr.Reedy’s

Package: 1 vial

Strength : 2mg & 3.5mg

Mechanism of action:


Myezom (Bortezomib) is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The active site of the proteasome has chymotrypsin-like, trypsin-like, and postglutamyl peptide hydrolysis activity. The 26S proteasome degrades various proteins critical to cancer cell survival, such as cyclins, tumor suppressors, BCL-2, and cyclin-dependent kinase inhibitors. Inhibition of these degradations sensitizes cells to apoptosis. Myezom (Bortezomib) is a potent inhibitor of 26S proteasome, which sensitizes activity in dividing multiple myeloma and leukemic cells, thus inducing apoptosis


Dosage and Administration:


Use Myezom (Bortezomib) as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Drinking extra fluids while you are taking Myezom (Bortezomib) is recommended. Check with your doctor for instructions.

  • Myezom (Bortezomib) is given as an injection into a vein or under the skin at your doctor's office, hospital, or clinic. Myezom (Bortezomib) is not intended to be injected into the spinal cord. Contact your health care provider if you have any questions.

  • It is very important that each dose is given at the scheduled time. If you miss a dose of Myezom (Bortezomib), contact your doctor right away to establish a new dosing schedule. Do not use 2 doses at once.

  • Ask your health care provider any questions you may have about how to use Myezom (Bortezomib).

Side effects:


Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Constipation; diarrhea; dizziness; headache; loss of appetite; mild stomach pain; nausea; stomach upset; taste changes; tiredness; trouble sleeping; vomiting; weakness.


Store:


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing .Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.


Precaution:


  • Before starting Myezom (Bortezomib) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.

  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Myezom (Bortezomib).

WARNING:


Myezom is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



Velcade



Velcade (Bortezomib) is used to treat multiple myeloma and mantle cell lymphoma.


Velcade (Bortezomib) is sometimes given after other cancer medications have been tried without successful treatment.



Brand name: Velcade

Active Ingeridents:Bortezomib

Company Name: Millennium

Package: 1 vial

Strength : 3.5mg

Mechanism of action:


Velcade (Bortezomib) is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The active site of the proteasome has chymotrypsin-like, trypsin-like, and postglutamyl peptide hydrolysis activity. The 26S proteasome degrades various proteins critical to cancer cell survival, such as cyclins, tumor suppressors, BCL-2, and cyclin-dependent kinase inhibitors. Inhibition of these degradations sensitizes cells to apoptosis. Velcade (Bortezomib) is a potent inhibitor of 26S proteasome, which sensitizes activity in dividing multiple myeloma and leukemic cells, thus inducing apoptosis


Dosage and Administration:


Use Velcade (Bortezomib) as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Drinking extra fluids while you are taking Velcade (Bortezomib) is recommended. Check with your doctor for instructions.

  • Velcade (Bortezomib) is given as an injection into a vein or under the skin at your doctor's office, hospital, or clinic. Velcade (Bortezomib) is not intended to be injected into the spinal cord. Contact your health care provider if you have any questions.

  • It is very important that each dose is given at the scheduled time. If you miss a dose of Velcade (Bortezomib), contact your doctor right away to establish a new dosing schedule. Do not use 2 doses at once.

  • Ask your health care provider any questions you may have about how to use Velcade (Bortezomib).

Side effects:


Check with your doctor if any of these most COMMON side effects persist or become bothersome:


Constipation; diarrhea; dizziness; headache; loss of appetite; mild stomach pain; nausea; stomach upset; taste changes; tiredness; trouble sleeping; vomiting; weakness.


Store:


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing .Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.


Precaution:


  • Before starting Velcade (Bortezomib) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.

  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Velcade (Bortezomib).

WARNING:


Velcade is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.