This medication is used to treat leukemia and other cancers. It works by slowing or stopping the growth of cancer cells.
Fludara (Fludarabine phosphate) phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Use Fludara (Fludarabine phosphate) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Fludara (Fludarabine phosphate) is usually handled and stored by a health care provider. If you are using Fludara (Fludarabine phosphate) at home, store Fludara (Fludarabine phosphate) as directed by your pharmacist or health care provider. Keep Fludara (Fludarabine phosphate) out of the reach of children and away from pets.
Nausea, vomiting, diarrhea, and loss of appetite may occur. Nausea and vomiting can be severe. In some cases, drug therapy may be needed to prevent or relieve nausea and vomiting. Not eating before your treatment may help relieve vomiting. Changes in diet and lifestyle, such as eating several small meals and limiting activity, may help lessen some of these effects. If any of these effects continue or worsen, notify your doctor or pharmacist.
Before using Fludara (Fludarabine phosphate), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Tell your doctor your medical history, especially of: current infections, certain virus illnesses (herpes, chickenpox), blood disorders (e.g., anemia, clotting problems), and kidney problems.
Fludara (Fludarabine phosphate) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.