NEVIRAPINE



Nevimune


Indication:


This drug is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Nevimune (Nevirapine) belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).



Brand name:Nevimune

Active Ingeridents:Nevirapine

Company Name:Cipla

Package:60 Tablets/Bottle

Strength :200mg

Mechanism of action:


Nevimune (Nevirapine) falls in the non-nucleoside reverse transcriptase inhibitor (NNRTI) class of antiretrovirals. Both nucleoside and non-nucleoside RTIs inhibit the same target, the reverse transcriptase enzyme, an essential viral enzyme which transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the active site termed the NNRTI pocket.

Nevimune (Nevirapine) is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class.

Resistance to Nevimune (Nevirapine) develops rapidly if viral replication is not completely suppressed. The most common mutations observed after Nevimune (Nevirapine) treatment are Y181C and K103N, which are also observed with other NNRTIs. As all NNRTIs bind within the same pocket, viral strains which are resistant to Nevimune (Nevirapine) are usually also resistant to the other NNRTIs, efavirenz and delavirdine. However, second generation NNRTIs like rilpivirine and etravirine are effective in treatment for HIV strains resistant to Nevimune (Nevirapine) and other first generation drugs in that same class.


Dosage and Administration:


Use Nevimune (Nevirapine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Nevimune (Nevirapine) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Nevimune (Nevirapine) refilled.

  • Take Nevimune (Nevirapine) by mouth with or without food.

  • Taking Nevimune (Nevirapine) at the same time each day will help you remember to take it.

  • Continue to take Nevimune (Nevirapine) even if you feel well. Do not miss any doses.

  • If you miss a dose of Nevimune (Nevirapine), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking Nevimune (Nevirapine) for more than 7 days, contact your doctor before you start to take it again.

Side effects:


Tiredness, nausea, vomiting, or diarrhea may occur. Drowsiness may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.


Precaution:


Before taking Nevimune (Nevirapine), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems (such as hepatitis B or C, cirrhosis), kidney dialysis, lactose or galactose intolerance.


Store:


Store Nevimune (Nevirapine) at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a tightly closed container away from heat, moisture, and light.


WARNING:


Nevimune (Nevirapine) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.










Viramune



Indication:


This drug is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Viramune (Nevirapine) belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).



Brand name:Viramune

Active Ingeridents:Nevirapine

Company Name:Boehringer

Package:60 Tablets/Bottle

Strength :200mg

Mechanism of action:


Viramune (Nevirapine) falls in the non-nucleoside reverse transcriptase inhibitor (NNRTI) class of antiretrovirals. Both nucleoside and non-nucleoside RTIs inhibit the same target, the reverse transcriptase enzyme, an essential viral enzyme which transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the active site termed the NNRTI pocket.

Viramune (Nevirapine) is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class.

Resistance to Viramune (Nevirapine) develops rapidly if viral replication is not completely suppressed. The most common mutations observed after Viramune (Nevirapine) treatment are Y181C and K103N, which are also observed with other NNRTIs. As all NNRTIs bind within the same pocket, viral strains which are resistant to Viramune (Nevirapine) are usually also resistant to the other NNRTIs, efavirenz and delavirdine. However, second generation NNRTIs like rilpivirine and etravirine are effective in treatment for HIV strains resistant to Viramune (Nevirapine) and other first generation drugs in that same class.


Dosage and Administration:


Use Viramune (Nevirapine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Viramune (Nevirapine) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Viramune (Nevirapine) refilled.

  • Take Viramune (Nevirapine) by mouth with or without food.

  • Taking Viramune (Nevirapine) at the same time each day will help you remember to take it.

  • Continue to take Viramune (Nevirapine) even if you feel well. Do not miss any doses.

  • If you miss a dose of Viramune (Nevirapine), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking Viramune (Nevirapine) for more than 7 days, contact your doctor before you start to take it again.

Side effects:


Tiredness, nausea, vomiting, or diarrhea may occur. Drowsiness may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.


Precaution:


Before taking Viramune (Nevirapine), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems (such as hepatitis B or C, cirrhosis), kidney dialysis, lactose or galactose intolerance.


WARNING:


Viramune (Nevirapine) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.


Store:


Store Viramune (Nevirapine) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light.