SUNITINIB MALATE



Suninat


Indication:


Treating a certain type of stomach, bowel, or esophagus tumor in certain patients. It is also used to treat certain types of kidney or pancreatic cancer. It may also be used for other conditions as determined by your doctor. Suninat (Sunitinib Malate) is a multikinase inhibitor. It works by preventing the growth of cancer cells.



Brand name:Suninat

Active Ingeridents:Sunitinib Malate

Company Name:Natco

Package: 28 Capsules

Strength :50mg

Mechanism of action:


Sunitinib is a small molecule that inhibits multiple RTKs, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. Sunitinib was evaluated for its inhibitory activity against a variety of kinases (>80 kinases) and was identified as an inhibitor of platelet-derived growth factor receptors (PDGFRa and PDGFRb), vascular endothelial growth factor receptors (VEGFR1, VEGFR2 and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony stimulating factor receptor Type 1 (CSF-1R), and the glial cell-line derived neurotrophic factor receptor (RET). Sunitinib inhibition of the activity of these RTKs has been demonstrated in biochemical and cellular assays, and inhibition of function has been demonstrated in cell proliferation assays. The primary metabolite exhibits similar potency compared to sunitinib in biochemical and cellular assays.


Dosage and Administration:


Use Suninat (Sunitinib Malate) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Suninat (Sunitinib Malate) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Suninat (Sunitinib Malate) refilled.

  • Take Suninat (Sunitinib Malate) by mouth with or without food.

  • Swallow Suninat (Sunitinib Malate) whole. Do not open the capsules. Do not break, crush, or chew before swallowing.

  • Do not eat grapefruit or drink grapefruit juice while you take Suninat (Sunitinib Malate).

  • If you miss a dose of Suninat (Sunitinib Malate), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Tell your health care provider about any missed dose.

  • Ask your health care provider any questions you may have about how to use Suninat (Sunitinib Malate).

Side effects:


The most common side effects are fatigue, diarrhea, nausea, anorexia, hypertension, a yellow skin discoloration, hand-foot skin reaction, and stomatitis.


Store:


Suninat (Sunitinib Malate) room temperature away from moisture and heat.


Precaution:

Before taking Suninat (Sunitinib Malate), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.




WARNING:


Suninat (Sunitinib Malate) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.


















Sutent



Indication:


Treating a certain type of stomach, bowel, or esophagus tumor in certain patients. It is also used to treat certain types of kidney or pancreatic cancer. It may also be used for other conditions as determined by your doctor. Sutent (Sunitinib Malate) is a multikinase inhibitor. It works by preventing the growth of cancer cells.



Brand name: Sutent

Active Ingeridents: Sunitinib Malate

Company Name: Pfizer

Package:28 Capsules

Strength :12.5mg

Mechanism of action:


Sutent is a small molecule that inhibits multiple RTKs, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. Sutent was evaluated for its inhibitory activity against a variety of kinases (>80 kinases) and was identified as an inhibitor of platelet-derived growth factor receptors (PDGFRa and PDGFRb), vascular endothelial growth factor receptors (VEGFR1, VEGFR2 and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony stimulating factor receptor Type 1 (CSF-1R), and the glial cell-line derived neurotrophic factor receptor (RET). Sutent inhibition of the activity of these RTKs has been demonstrated in biochemical and cellular assays, and inhibition of function has been demonstrated in cell proliferation assays. The primary metabolite exhibits similar potency compared to Sutent in biochemical and cellular assays.


Dosage and Administration:


Use Sutent (Sunitinib Malate) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Sutent (Sunitinib Malate) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Sutent (Sunitinib Malate) refilled.

  • Take Sutent (Sunitinib Malate) by mouth with or without food.

  • Swallow Sutent (Sunitinib Malate) whole. Do not open the capsules. Do not break, crush, or chew before swallowing.

  • Do not eat grapefruit or drink grapefruit juice while you take Sutent (Sunitinib Malate).

  • If you miss a dose of Sutent (Sunitinib Malate), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Tell your health care provider about any missed dose.

  • Ask your health care provider any questions you may have about how to use Sutent (Sunitinib Malate).

Side effects:


The most common side effects are fatigue, diarrhea, nausea, anorexia, hypertension, a yellow skin discoloration, hand-foot skin reaction, and stomatitis.


Precaution:


Before taking Sutent (Sunitinib Malate), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.


Store:


Sutent (Sunitinib Malate) room temperature away from moisture and heat.


WARNING:


Sutent (Sunitinib Malate) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.