Xbira 250 Tablet

Description of Xbira 250 (Abiraterone Acetate 250mg) tablet 

Xbira 250 tablets has 250mg of active ingredient Abiraterone Acetate, which is a drug mostly given for treating an some cancer that is prostate cancer, also called cancer of the male gland. The medicine works by inhibiting androgen biosynthesis so it blocks how male hormones are made like testosterone which promote prostate cancer cell increasing.By drop down these hormones, Abiraterone can help slow, and sometimes stop growth and also spreading of prostate cancer cells.

Indications of Xbira 250 (Abiraterone Acetate 250mg) tablet 

Xbira tablets are helpful in treating an adult men who have metastatic castration-resistant prostate cancer (mCRPC). This is like a type of prostate cancer that keeps growing even though testosterone is already lowered. Doctors may tell to take this medicine with the prednisone or prednisolone for handling side effects due to lower steroid hormones. Sometimes, for men with metastatic a high-risk castration-sensitive prostate cancer (mCSPC), it is given to slow disease getting worse and better survival.

Mechanism of action of Xbira 250 (Abiraterone Acetate 250mg) tablet 

Xbira 250 tablet produces its action by inhibiting the enzyme called CYP17, which is essential for the production of androgens. This medicine decrease the secretion of testosterone produced in the testes, adrenal gland and inside the tumor which reduce the level of hormone helps to stop the growth of cancer.

How to consume Xbira 250 (Abiraterone Acetate 250mg) tablet 

People must use Abiraterone acetate 250mg tablet strictly in amount the doctor decides for you. Most often, drug is taken one time every day, and you can take it on empty stomach. You have to make sure about swallowing each tablet whole and should not break, chew or open it.

Side Effects of Xbira 250 (Abiraterone Acetate 250mg) tablet 

1. Common side effects

• Feeling tired
• Swelling in the legs or feet
• High blood pressure
• Joint pain
• Low potassium levels in blood

2. Serious side effects

• Chest pain
• Indications of liver trouble (like having yellow skin or eyes)
• Allergic issues (rashes itchy, or swelling)
• Feeling very weak

3. Rare side effects

• Bone fractures
• Sudden mood changes
• Weight gain

Safety Advice for Xbira 250 (Abiraterone Acetate 250mg) tablet 

The patients who are taking Abiraterone Acetate must be well evaluated regarding the possible adverse effects, such as cardiovascular caused by abiraterone acetate, heart failure, arrhythmias, hypertension, fluid retention, and hepatic dysfunction. The doctor might ask for often checking of the liver and kidney working too.

Breastfeeding: Limited information is available regarding the use of this medicine in patients during breastfeeding. But on animal studies it shows an harmful effect on fetus, so it is better to avoid during breastfeeding.

Pregnancy: It is considered unsafe to use this medicine during pregnancy because this may cause harmful effect to the fetus. Kindly consult with your doctor for further information.

Alcohol: There must be a reduction in taking alcohol since it might give higher risk of some impacts.

Liver: Patients having liver problems should use with care.

Lungs: If some lung disease is already there, it must be talked with your doctor before you start.

Kidney: Patients having kidney problems should use with care.

Driving: Tiredness and feeling dizzy can be possible, so machines and driving must be done with care.

Interaction of Xbira 250 (Abiraterone Acetate 250mg) tablet 

• Drug-Drug Interaction :

Apalutamide x Abiraterone acetate

Use another drug because the use of apalutamide will decrease the effect of abiraterone by affecting its hepatic and intestinal enzyme metabolism.

Spironolactone x Abiraterone acetate

It is contraindicated to use this medicine because the use of spironolactone increases the toxicity of abiraterone by pharmacodynamic synergism.

Topotecan x Abiraterone acetate

Use another drug because the use of abiraterone will increase the effect of topotecan by P-glycoprotein efflux transporter.

Dichlorphenamide x Abiraterone acetate

Careful use should be accompanied by therapeutic administration since the combined use of this drug has been linked to the decrease of serum potassium levels.

• Drug-Food Interaction:

Food:

Taking this medicine along with food may increase the side effects such as high blood pressure, low potassium level in blood, water retention which leads to irregular heart rhythm, weakness, and paralysis. So do not take this medicine two hours before and one hour after food.

• Drug-Disease Interaction:

Hepatic impairment:

Therapy should be administered with caution because the use of this medicine may cause liver failure.

Cardiovascular disease:

Therapy should be administered with caution because the use of this medicine may cause fluid retention, hypertension, and hypokalemia

Contraindication of Xbira 250 (Abiraterone Acetate 250mg) tablet 

Therapy should be administered with caution in patients with history of cardiovascular disease.

The use of this drug can cause hypokalemia and adrenocortical insufficiency.

Dosage of Xbira 250 (Abiraterone Acetate 250mg) tablet 

Dose depends on the type of cancer. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Xbira 250 (Abiraterone Acetate 250mg) tablet 

Abiraterone acetate tablets must be kept at ambient room temperature under the influence of moisture or heat.. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Xbira 250 (Abiraterone Acetate 250mg) tablet 

In case of one dose being missed, the patient can continue with the nxt dosing schedule as per the programmed dosing schedule. Taking two tablets together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Xbira 250 (Abiraterone Acetate 250mg) tablet 

The use of Xbira 250 tablet might create dry skin, so using proper moisturizer is recommended by the doctors. Stay hydrated by drinking water and eat with more balanced as much as you can. Attending frequent checkups with doctor is important during treatment; you should notify any strange side effects as soon as possible. In case you need additional information or instructions about your case, contact your physician.

FAQs of Xbira 250 (Abiraterone Acetate 250mg) tablet 

1. What is the clinical justification of the use of abiraterone together with prednisone or prednisolone?

Abiraterone drops some hormone levels down, which might cause some unwanted reactions. Taking it at the same time as the prednisone or prednisolone helps with balancing hormones and can make side effects such as feeling lot of tiredness or having swelling happen less.

2. Is it possible to take Abiraterone with meals?

You cannot. You should take Abiraterone while your stomach is empty since eating food can make your body absorb more of the medicine and then there can be a greater risk of side effects.

3. What side effects are typical with Abiraterone?

Typical unwanted reactions are being tired, swelling your legs or even ankles, having high pressure of the blood, potassium becoming low, troubles with pain in joints and sometimes getting hot flashes.

4. What do you need to stay away from on the Abiraterone?

You should keep away from grapefruit juice or drinking of alcohol, because these may add more possible side effects. Be sure you report to your doctor any medicines you take already even herbs.

5. Abiraterone is either used in women or in a paediatric patient?

The existing evidence shows that the abiraterone is recommended only in adult male patients with prostate carcinoma; in women or in children, the use of this drug is not approved.

Fact Box of Xbira 250 (Abiraterone Acetate 250mg) tablet  :

References

1. DrugBank – Abiraterone indications & pharmacology
   https://go.drugbank.com/drugs/DB05812
2. MedlinePlus – Abiraterone uses and precautions
   https://medlineplus.gov/druginfo/meds/a612037.html
3. Mayo Clinic – Abiraterone clinical use & side effects
   https://www.mayoclinic.org/drugs-supplements/abiraterone-oral-route/description/drg-20074889
4. Medscape – Abiraterone monograph
   https://reference.medscape.com/drug/zytiga-abiraterone-acetate-999611
5. National Cancer Institute (NCI) – Abiraterone information https://www.cancer.gov/about-cancer/treatment/drugs/abirateroneacetate