Daslemia 100 Tablet

Description of Daslemia 100 (Dasatinib 100mg) tablet

A pharmacologic agent that is used in the treatment of chronic myeloid leukaemia and acute lymphoid leukaemia is Dasatinib 100mg, which is prescribed in the form of Daslemia 100 tablet. This is a tyrosine-kinase-inhibtor (TKI), which has antitumor effects, that is selective in blocking the growth and metastasis of malignant cells, as a result, it helps to reduce the tumour load.

Indications of Daslemia 100 (Dasatinib 100mg) tablet

Daslemia 100 tablet is given for treatment for certain type of blood cancer such as chronic myeloid leukemia (CML), and acute lymphoblastic leukaemia (ALL). This medicine is used in patients who could not be treated with other medicine for leukemia.

Mechanism of action of Daslemia 100 (Dasatinib 100mg) tablet 

Dasatinib tablet is a tyrosine kinase inhibitor that produces its action by inhibiting the supply of oxygen and nutrient which is required for the growth of cancer cell.

How to consume of Daslemia 100 (Dasatinib 100mg) tablet

People must use Dasatinib tablet strictly in amount the doctor decides for you. Most often, drug is taken one time every day, and you can take it with food or without having any food. You have to make sure about swallowing each tablet whole and should not break, chew or open it.

Side Effects of Daslemia 100 (Dasatinib 100mg) tablet

1. Common side effects

• Feeling tired
• Headache
• Problems with diarrhea
• Mild swelling in hands or feet
• Appetite gets lower

2. Serious side effects

• Chest pain, arrhythmia
• Hepatic malfunction
• Allergic issues
• Severe bleeding

3. Rare side effects

• Low potassium level in blood
• Muscle spasm
• Severe stomach pain

Safety Advice for Daslemia 100 (Dasatinib 100mg) tablet

People who are using Dasatinib need proper checking for probable bad impacts, for example, low blood cell counts, bleeding, or accumulation of fluid around the lungs. The doctor might ask for often checking of the liver and kidney working too.

Breastfeeding: The use of the drug is regarded as contraindicated during lactation. It is recommended to consult a clinician in order to get additional information.

Pregnancy: The usage of the drug is contraindicated in case of pregnancy because it may have teratogenic effects. It is recommended to consult a clinician to have more information.

Alcohol: There must be a reduction in taking alcohol since it might give higher risk of some impacts.

Liver: Patients having liver problems should use with care.

Lungs: If some lung disease is already there, it must be talked with your doctor before you start.

Kidney: Patients having kidney problems should use with care.

Driving: It is not clear whether it is safe to consume alcohol while you are receiving this medicine.

Interaction of Daslemia 100 (Dasatinib 100mg) tablet

• Drug-Drug Interaction :

Pimozide x Dasatinib

It is contraindicated to use this medicine because the use of dasatinib will increases the effect of pimozide by decreasing its metabolism and it also increase the prolongation of QT interval..

Aluminum hydroxide x Dasatinib

Use alternative drug because the use of aluminum hydroxide will decrease the effect of dasatinib by increasing its gastric pH.

Chloramphenicom x Dasatinib

Use alternative drug because the use of chloramphenicol will increase the effect of dasatinib by affecting its hepatic ad intestinal enzyme metabolism.

Dichlorphenamide x Dasatinib

Therapy should be administered with caution because the combination of this medicine decrease the level of serum potassium.

Loperamide x Dasatinib

Therapy should be administered with caution because the combination of this medicine increase the QTc interval.

• Drug-Food Interaction:

Food:

Do not take grapefruit while you are receiving this medicine because grapefruit may increase the blood levels which leads to slow heart rate. Kindly contact doctor if you have experience dizziness, lightheadedness, shortness of breath, bleeding, weight loss, chills, and diarrhea.

• Drug-Disease Interaction:

Cardiovascular disease:

There should be caution in the administration of this therapeutic agent and its administration has been linked to arterial and peripheral vascular occlusive events, and ischemic cerebrovascular incidents.

Fluid retention:

Therapy should be administered with caution in patients with congestive heart failure because the use of this medicine may cause pericardial effusion, pleural effusion, pulmonary edema and peripheral edema.

Bone marrow suppression:

Pharmacologic exposure to this agent in persons with a history of bone marrow suppression will cause thrombocytopenia, aplastic anaemia, agranulocytosis, and neutropenia and thus therapeutic intervention should be done cautiously. Pulmonary arterial hypertension: The use of this agent has been linked to a high incidence of developing pulmonary arterial hypertension and this may occur through symptoms that include dyspnea, fatigue, hypoxia and retention of fluid.

Pulmonary arterial hypertension:

The clinical information suggests that the exposure to its agent is associated with an increased risk of pulmonary arterial hypertension that has such symptoms as dyspnea, fatigue, hypoxia, and fluid retention.

Contraindication of Daslemia 100 (Dasatinib 100mg) tablet

It is contraindicated to use this medicine in patients with hepatic impairment.

The use of this medicine may cause cardiac adverse reactions, tumor lysis syndrome, embroyofetal toxicity, and bleeding.

The use of this medicine increase the risk of fluid retention and pleural effusion.

Dosage of Daslemia 100 (Dasatinib 100mg) tablet

Dose depends on the type of cancer. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Daslemia 100 (Dasatinib 100mg) tablet

Tablets of Dasatinib need to be kept somewhere with average room temperature conditions, protecting it from too much moisture or heat. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Daslemia 100 (Dasatinib 100mg) tablet

If you miss one tablet, just use planned next dose on the regular schedule. Taking two tablets together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Daslemia 100 (Dasatinib 100mg) tablet 

The use of Daslemia 100 tablet might create dry skin, so using proper moisturizer is recommended by the doctors. Stay hydrated by drinking water and eat with more balanced as much as you can. Attending frequent checkups with doctor is important during treatment; you should notify any strange side effects as soon as possible. If you want further instructions or details for your case, contact your doctor.

FAQs of Daslemia 100 (Dasatinib 100mg) tablet 

1. What about when one feels extremely tired or lightheaded?

It is advisable that the person should alert his doctor when he experiences such symptoms. The doctor will then alter the dose of the same.

2. Can Dasatinib tablet cause severe lung issues?

Yes, the use of this medicine may cause pleural effusion which leads to difficulty in breathing, chest pain, and cough. Kindly inform your doctor if you have developed this symptoms.

3. Is Dasatinib high-speed tablet known to cause bleeding?

Yes, it is possible that the use of this medicine can increase the risk of bleeding. Please tell your physician whether or not you have had blood in your stools.

4. Is it possible to concomitant Dasatinib with other medicine?

You should tell your doctor about the history of your medication on consultation given that there are drugs that can amplify the side effects.

5. Does Dasatinib have an impact on fertility?

No, the prescription of this drug can lower the fertility rates of both men and women. Please also advise your physician in case you are going to have a baby.

Fact Box of Daslemia 100 (Dasatinib 100mg) tablet  :

Field	Details
Generic/Molecule Name	Dasatinib
Therapeutic Class	Anti-neoplastic agent
Pharmacological Class	Tyrosine kinase inhibitor
Dosage form	tablet
Habit forming	No
Indication	Blood cancer

References

• National Cancer Institute. Dasatinib (Sprycel) Drug Information.
  https://www.cancer.gov/about-cancer/treatment/drugs/dasatinib
• U.S. Food and Drug Administration (FDA). Sprycel (Dasatinib) Prescribing Information.
  https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/021986s044lbl.pdf
• National Center for Biotechnology Information (NCBI). PubChem Compound Summary for CID 3062316, Dasatinib.
  https://pubchem.ncbi.nlm.nih.gov/compound/Dasatinib
• Cancer Research UK. Dasatinib (Sprycel) Information for Patients. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/dasatinib
• MedlinePlus. Dasatinib Oral – Uses, Side Effects, and Precautions.
  https://medlineplus.gov/druginfo/meds/a607034.html