Ledomed 15 Capsule

Description of Ledomed 15 (Lenalidomide 15mg) capsule 

Ledomed 15 capsules are made of 15mg of lenalidomide which is an agent used in the treatment of some neoplasms such as multiple myeloma and myelodysplastic syndromes. The medicine works like an immune modulator it fights cancer cells because it tries to control the immune system function.

Indications of Ledomed 15 (Lenalidomide 15mg) capsule 

Ledomed 15 capsule is used in treatment of multiple myeloma, which is a plasma cell neoplastic disorder of the bone marrow. This is a malignancy that is a type of blood cancer, which is associated with the marrow microenvironment and the clonal proliferation of malignant plasma cells. Adjunctive medicines, like dexamethasone, are common in order to increase the therapeutic efficacy. Moreover, clinicians also prescribe this drug to patients with myelodysplastic syndrome as a clonal hematopoietic pathology that develops when the bone marrow is unable to produce blood cells in people with a del(5q) chromosomal anomaly.

Mechanism of action of Ledomed 15 (Lenalidomide 15mg) capsule 

Ledomed 15 capsule is used like a medicine for cancer. It is one of an angiogenesis inhibitors which can work by stopping cancer cell growing and raising the immune system. It is also keeping away making of several chemical messengers for example cytokine and growth factor, and those are making more cancer cells grow.

How to consume Ledomed 15 (Lenalidomide 15mg) capsule 

People must use Lenalidomide capsule strictly in amount the doctor decides for you. Most often, drug is taken one time every day, and you can take it with food or without having any food. You have to make sure about swallowing each capsule whole and should not break, chew or open it.

Side Effects of Ledomed 15 (Lenalidomide 15mg) capsule

1. Common side effects

• Feeling tired
• Low blood counts
• Problems with diarrhea
• Loss in weight
• Appetite gets lower

2. Serious side effects

• Heart-related cases
• Indications of liver trouble (like having yellow skin or eyes)
• Allergic issues (rashes itchy, or swelling)
• Blood clots in legs

3. Rare side effects

• Abnormal passage between organs
• Thyroid malfunction
• Severe stomach pain

Safety Advice for Ledomed 15 (Lenalidomide 15mg) capsule

Close follow-ups of patients on lenalidomide treatment are also crucial to detect the adverse events, such as cardiotoxicity (in the form of heart failure or heart arrhythmias), hematologic, and infectious conditions early in the treatment process.

Breastfeeding:  The available sources have insufficient evidence on how this agent can be used in lactation.

Pregnancy: The use of this medicine may cause harmful effect to the fetus. Kindly consult with your doctor for further information.

Alcohol: There must be a reduction in taking alcohol since it might give higher risk of some impacts.

Liver: Patients having liver problems should use with care.

Lungs: If some lung disease is already there, it must be talked with your doctor before you start.

Kidney: Patients having kidney problems should use with care.

Driving: Tiredness and feeling dizzy can be possible, so machines and driving must be done with care.

Interaction of Ledomed 15 (Lenalidomide 15mg) capsule 

• Drug-Drug Interaction :

Anakinra × Lenalidomide 

Co-administration of Anakinra with Lenalidomide is also contraindicated because it has been proposed that the effect can render one prone to the infectious agents.

Deferiprone × Lenalidomide 

Other pharmacotherapies are also possible, as the interaction between Deferiprone and Lenalidomide has been found to augment the toxicity of Deferiprone through pharmacodynamic synergism.

Lenalidomide 1:1 mixed with dichlorphenamide. 

The therapeutic regimens are to be handled cautiously because the combination between Dichlorphenamide and Lenalidomide can cause hypokalaemia because of the decreased level of serum potassium.

Hydroxyurea × Lenalidomide 

Close observation is justified by the fact that interaction between hydroxyurea and lenalidomide increases the chances of myelosuppression.

Digoxin × Lenalidomide 

Lenalidomide is contraindicated in patients who have diabetes and thyroid disease since it can enhance the levels of digoxin in the blood, thus, augmenting its pharmacologic and toxic effects.

• Drug-Food Interaction:

No data available. Kindly consult with your doctor.

• Drug-Disease Interaction:

Kidney impairment:

Therapy is required to be provided carefully since this medication is not changed, so please change dose for those having serious or a moderate kidney problems also for people using dialysis.

Thromboembolic problems:

Therapy is needed to be given with a caution that this medicine sometimes develops vein thromboembolic conditions like deep vein thrombosis, pulmonary embolism or artery thromboses.

Anemia:

Therapy should be administered with caution because the use of this medicine may cause anemia, neutropenia, and thrombocytopenia so kindly monitor patients complete blood counts.

Contraindication of Ledomed 15 (Lenalidomide 15mg) capsule 

It is contraindicated to use this medicine in patient during pregnancy.

The use of the medicine may increase the risk of hematologic toxicity.

The side effects that can be ascribed to this medication include tumour lysis syndrome, tumour flare reaction, poor mobilisation of the stem cells, hypothyroidism and hyperthyroidism.

Dosage of Ledomed 15 (Lenalidomide 15mg) capsule 

Dose depends on the type of cancer. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Ledomed 15 (Lenalidomide 15mg) capsules 

Lenalidomide capsules are to be kept at ambient room  temperature, but they have to be protected against the high humidity and temperature. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Ledomed 15 (Lenalidomide 15mg) capsules

If you miss one capsule, just use planned next dose on the regular schedule. Taking two capsules together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Ledomed 15 (Lenalidomide 15mg) capsules 

The use of Ledomed 15 Capsule might create dry skin, so using proper moisturizer is recommended by the doctors. Stay hydrated by drinking water and eat with more balanced as much as you can. Attending frequent checkups with doctor is important during treatment; you should notify any strange side effects as soon as possible. If you want further instructions or details for your case, contact your doctor.

FAQs of Ledomed 15 (Lenalidomide 15mg) capsule

1. Is it safe to use Ledomed 15 capsule in patients under dialysis?

The answer to this is yes; however, it is also recommended that Lenalidomide 15mg capsules can be used on patients under dialysis, but they should consult a doctor before taking it.

2. Does lenalidomide have any concomitant pharmacological agents?

The patients are advised to report all of the concurrent medications to their physician in order to prevent potential adverse interactions.

3. Ledomed 15 capsule: How often should I take?

The amount of time during therapy is to be established upon the dosage schedule provided to the client by the treating clinician; any sudden withdrawal will lead to severe side effects.

4. Is it possible to combine other medication with Ledomed 15 mg Capsule?

It is always necessary to fully disclose the history of medication to the physician as there are certain drugs which can enhance the frequency or occurrence of adverse effects.

5. Is it possible to have herbal supplements or vitamins?

Patients must report to their physician about any vitamins or supplements he/she takes as they may pharmacologically interact with Lenalidomide.

Fact Box of Ledomed 15 (Lenalidomide 15mg) Capsule:

Field	Details
Generic/Molecule Name	Lenalidomide
Therapeutic Class	Anti-neoplastic agent
Pharmacological Class	Immunomodulatory drug
Dosage form	Capsule
Habit forming	No
Indication	Multiple myeloma, myelodysplastic syndrome

References

DrugBank – Lenalidomide indications & pharmacology.
https://go.drugbank.com/drugs/db00480

MedlinePlus – Lenalidomide uses and how to take
https://medlineplus.gov/druginfo/meds/a608001.html

Mayo Clinic – Lenalidomide clinical use & side effects
https://www.mayoclinic.org/drugs-supplements/lenalidomide-oral-route/description/drg-20068352

Blood Cancer United – Lenalidomide approved indications
https://bloodcancerunited.org/blood-cancer-care/cancer-drug-listing/lenalidomide

MedEx – Lenalidomide indications summary
https://medex.com.bd/generics/669/lenalidomide