This Medicine is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Abacavir and lamivudine both belong to a class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs).

Brand name:Epzicom

Active Ingeridents:Abacavir-Lamivudine

Company Name: Glaxosmithkline

Package:30 Tablets /Bottle

Strength :Abacavir 600mg + Lamivudine 300mg

Mechanism of action:


Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation.


Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.

Dosage and Administration:

Use Epzicom (Abacavir-Lamivudine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Epzicom (Abacavir-Lamivudine) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Epzicom (Abacavir-Lamivudine) refilled.

  • Epzicom (Abacavir-Lamivudine) comes with a warning card that provides information about recognition of allergic reactions. Carry the warning card of allergy symptoms with you. Tell your health care provider immediately about any side effects you experience while taking Epzicom (Abacavir-Lamivudine).

  • Take Epzicom (Abacavir-Lamivudine) by mouth with or without food.
  • Ask your health care provider any questions you may have about how to use Epzicom (Abacavir-Lamivudine).


Store Epzicom (Abacavir-Lamivudine) at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Keep Epzicom (Abacavir-Lamivudine) out of the reach of children and away from pets.

Side effects:

Headache, nausea, diarrhea, dizziness, tiredness, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.


Before taking Epzicom (Abacavir-Lamivudine), tell your doctor or pharmacist if you are allergic to either of these drugs; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.


Epzicom (Abacavir-Lamivudine) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.