Generic : Abiraterone acetate
Trade name : Abirapro 250mg
Container : 120 tablets
Manufactured by : GlenmarkPharmaceuticals
Abiraterone is sold under brand name Abirapro


Abirapro is belongs to type of anti-cancer medication that will act by decline the androgen production in the body. Androgen is a male hormone that canmaintance the tumor cell in prostate glands, the main ingredient which is used as abiraterone . Actually thisdrug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by Abiraterone.


Androgens are balance the production of malignant in prostate. Abiraprois belongs to anti androgen drugs, thatcauses to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involves in androgen conglomerate. Reduce the serum testosterone level. Declined the tumor cell occurred.


Anyallergy, serious liver problem or pregnant in patient, Abiraprotherapy should be stopped Avoid taking of other medications, i.e prescription, over-the-counter, vitamins, herbal remedies, etc be sure to inform the doctors before the treatment. Do not take Aspirin administrated and products containing aspirin till doctor particularly allow the drug.


Time to maximum plasma concentration of Abiraprotablet takes 12 hours.
Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.
Themain two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.
The drug mainly excreted in 88% feces and 5% in urine Half-life of tablet Abirapro is 12 ± 5 hours.


Interaction of Abirapro with dextromethorphan will raises the Cmax and AUC of dextromethorphan Interaction Abirapro with strong CYP3A inhibitors or inducers , concomitant use with caution because pharmacokinetics is not evaluated.


Pregnancy category X: while ontherapy with Abirapro tablet if women become pregnant, immediately stop the drug and give counseling to the women. Abirapro tablet is not recommended for women.


The drug stored at 15℃ - 30℃. Keep the drug in dry place.


If patient missed the dose ofAbirapro, that missed dose will be skipped and follow the regular dosing schedule.


Common effects Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency,Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency Musculo skeletal and Connective tissue disorders:Joint swelling, discomfort, muscle discomfort General Disorder:Oedema Cardiac disorders:Hot flush, hypertension, arrhythmias, chest pain, cardiac failure GIT disorders:Diarrhea, dyspepsia Infections and Infestation:UTI Pulmonary disorder:Cough Renal:Urinary frequency, nocturia Injuries:Fractures


Abirapro has no essential antidote, If overdose occurs end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.

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