Composition : Abiraterone acetate
Strength availability : 250mg
Pack : 120 tablets

Abiraterone is sold under brand name Zytiga
Zytiga is belongs to type of anti-cancer medication that will act by decline the androgen production in the body. Androgen is a male hormone that canmaintance the tumor cell in prostate glands.
Actually this drug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by Abiraterone.


The prescribed dose of Zytiga is initial as 4 tablets given orally once daily.
The drug Zytiga administrated combination with 5mg prednisolone twice daily in empty stomach.
Zytiga Tablets given on an empty stomach.
Food should not be taken for at least 2 hours before and at least 1 hour after the dose of Zytiga Tablets is taken.
Swallowed whole with water.
Chew the tablets or Do not crush


Androgens are balance the production of malignant in prostate.
Zytigais belongs to anti androgen drugs, that causes to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involves in androgen conglomerate.
Reduce the serum testosterone level.
Declined the tumor cell occurred.


Time to maximum plasma concentration of Zytiga tablet takes 12 hours.
Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.
The main two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.
The drug mainly excreted in 88% feces and 5% in urine
Half-life of tablet Zytiga is 12 ± 5 hours.


Any allergy, serious liver problem or pregnant in patient, Zytiga therapy should be stopped
Avoid taking of other medications, i.e prescription, over-the-counter, vitamins, herbal remedies, etc be sure to inform the doctors before the treatment.
Do not take Aspirin administrated and products containing aspirin till doctor particularly allow the drug.
Zytiga has no essential antidote, If overdose occurs end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function


Interaction of Zytiga with dextromethorphan will raises the Cmax and AUC of dextromethorphan
Interaction Zytiga with strong CYP3A inhibitors or inducers , concomitant use with caution because pharmacokinetics is not evaluated.


The drug stored at 15℃ - 30℃
Keep the drug in dry place.


If patient missed the dose of Zytiga, that missed dose will be skipped and follow the regular dosing schedule.


Common effects :
Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency, Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency
Musculo skeletal and Connective tissue disorders:Joint swelling, discomfort, muscle discomfort
General Disorder: Oedema
Cardiac disorders: Hot flush, hypertension, arrhythmias, chest pain, cardiac failure
GIT disorders: Diarrhea, dyspepsia
Infections and Infestation:UTI
Pulmonary disorder: Cough
Renal:Urinary frequency, nocturia
Injuries: Fractures.

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