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acyclovir-400mg

PRODUCT DETAILS

Composition : Acyclovir
Strength availability : 400 mg
Packing : Pack of 10x5 tablets
Form : Tablet DT
Category : Anti-viral drug
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Zovirax 400 mg is also called as Acycloguanosine, which is belongs to antiviral medication.
Zovirax 400 mg is a type of nucleoside analogs (group of synthetic drugs), will inhibit the symptoms of infection contains Herpes Simplex Virus (HSV), this infection will cause herpes simplex or type of herpes virus VZV (varicella-Zoster virus) and thereby causes shingles and chickenpox.
Zovirax 400 mg is a prescription drugs administrated orally which is used under the supervision of medical practioners. Zovirax 200 mg is used with combination of other medications.

INDICATION

Zovirax 400 mg is used to reduce pain and fast healing of sores or blisters which is caused by varicella (chickenpox), Herpes Zoster.
Zovirax 400 mg is also used for the treatment of herpes virus infection which causes sore to form around the genitals and rectum from time to time (genital herpes) and hence prevents the outbreaks of genital herpes in people affected by virus.

DOSAGE

Herpes simplex- mucocutaneous/ immunocompetent host

Here it's mentions about Zovirax dosage

For adult dose: 200 mg orally every 4 hours or 5 times a day for 10 days.
For 5 to 10 days 400 mg orally 3 times a day is given.
For pediatric dose: less than 12 years 40 to 80 mg/kg/day orally, it can be divided into 3 to 4 times a day, max 5 to 10 days Max dose up to 1000 mg/day
12yrs or older: 200 mg orally 5 times a day every 4 hours 400mg orally 3 times a day
Duration: 7 – 10 days
Herpes simplex - mucocutaneous/ immunocompromised host
For adult dose: 400 mg orally 3 times a day Duration: up to 5 to 10 days
Severe disease: 5 mg/kg IV every 8 hours
Episodic treatment: 400 mg orally 3 times a day upto 5 to 14 days
For pediatric dose: <12 years: 10 mg/kg IV for every 8 hours upto 7 days
12 years or older: 5 mg/kg IV for every 8 hours upto 7 days
continues HIV infection
Mild Symptomatic Gingivostomatitis:20 mg/kg orally 4 times a day for 7 to 10 days ; Maximum dose: 400 mg
Moderate to Severe Gingivostomatitis:5 to 10 mg/kg IV 3 times a day
Herpes Simplex Encephalitis
For adult dose: 10mg/kg IV for every 8 hours Duration: 10days and center for disease control and prevention recommends 21 days
For pediatric dose: 3 months to 12 years old : IV 10 to 20 mg/kg for every 8 hours
12 years or older: 10 mg/kg IV every 8 hours
Duration: 10days and center for disease control and prevention recommends 21 days
Herpes Zoster
For adult dose: 800 mg orally every 4 hours ( 5 times a day) for 7 to 10 days
Immunocompromised host: 10 mg/kg IV every 8 hours for 7 days
Treatment Duration 7 to 14-day course (oral plus IV)
For pediatric dose: Immunocompetent Host: -Parenteral:
< 1 year: 10 mg/kg IV every 8 hours for 7 to 10 days
1 year or older: 500 mg/m2 IV every 8 hours for 7 to 10 days
Oral: 12 years or older: 800 mg orally 5 times a day for 5 to 7 days
Immunocompromised Host: 10 mg/kg IV every 8 hours for 7 to 10 days
OVERDOSAGE: Zovirax 400 mg involving ingestion of 100 capsules ( 20g) have been reported has agitation, coma, seizures and lethargy

PHARMACOLOGICAL

Zovirax is stimulated by phosphorylation before to that drug will inhibits the viral DNA synthesis.
Zovirax converted by addition of phosphate group to a viral enzyme known as thymidine kinase has more affinity.
HSV-TK or VZV-TK converts into acyclovir triphosphate by phosphorylation then fused into viral DNA, thereby stops further synthesis of DNA.
Since Zoviraxattack to a selective type of viral kinase, the drugs enters and works on those cells infected with HSV or VZV, hence it will disorganize the formation of herpesvirus DNA At high concentration has less activity in uninfected cells, Therefore HSV-TK or VZV-TK mutation will leads resistance to acyclovir.

PHARMACOLOGICAL

Absorption: Poorly water soluble, peak plasma concentration after 1-2 hours and bioavailability 15-30%.
Distribution : Plasma protein binding is ranging between 9 to 33%.
Elimination : Half life based according to age group neonates have t1/2 4 hours, children’s have 2-3 hours and for adults t1/2 3 hours.

DRUG INTERACTION

• When concomitant with probenecid will decrease tubular secretion of acyclovir and rise the blood plasma and half- life of acyclovir. • Concomitant use with nephrotoxic drugs may cause increase the risk in renal function
• Interact with immunostimulators will enhancing effects of acyclovir

CONTRAINDICATION

Zovirax is contraindicated in patients who causes hypersensitivity to acyclovir or valacyclovir..

PRECAUTION

• Zovirax400mg cause allgeric reaction like breathing trouble, swelling of throat or tongue, rash, hives. Inform your doctor if symptoms occurs.
• Discuss with your consultant about planning to become pregnant or pregnancy because drug can be used if possible benefits clarify possible risk to the patients.
• Discuss with doctor If you had kidney disease because the excretion of drug will not perform well, Zovirax 200 mg will decrease the kidney function.

ZOVIRAX SIDE EFFECTS

Common side effects :
• Weakness
• Vomiting
• Nausea
• Diarrhea
• Headache

ZOVIRAX SERIOUS SIDE EFFECTS

• Unusal changes in mood like aggressive behavior, confusion, speaking trouble, hallucinations, seizures, Coma.
• Reduced RBC and Platelets like fatigue
• Liver problems
• Myalgia
• Skin reaction like hair loss, rash, breaking or loosening of skin, hives
• Changes in your vision
• Kidney failure like flank pain, bloody urine

MISSED DOSE

Immediately adminster the medicine as you remember.If next dose time reaches swap the missed dose and continue the regular schedule. avoid taking double dose at a time. Please consult the doctor for futher details.

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