Abamune 300mg (Abacavir)

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Cipla Ltd

Abamune 300mg (Abacavir)

ManufacturerCipla LtdBrand nameAbamune International trade nameZiagenActive substanceAbacavirStrength300mgCategoryHIV

Description of Abamune 300mg tablet (Abacavir 300mg)

Abamune 300mg tablet is a combination tablet that contains ingredients like Abacavir. Abamune 300mg tablet is involved in the treatment of HIV-type I infection, it is used with other anti-retroviral medicines to control the infections. Abamune 300mg tablet is manufactured by Cipla and it is active against HIV viruses which effectively prevent it from progressing to AIDS.

Medical use /Indication of Abamune 300mg tablet (Abacavir 300mg)

Abamune 300mg tablet is indicated for the treatment of HIV type I infection patients.

Mechanism of Action Abamune 300mg tablet (Abacavir 300mg)

Abacavir is a nucleoside reverse transcriptase inhibitor (carboxylic synthetic nucleoside analogue), it has activity against human immunodeficiency virus type I. Abacavir is phosphorylated into an active metabolite carbovir triphosphate (deoxyguanosine 5’triphosphate) dGTP This active metabolite prohibits the action of reverse transcriptase by competing with dGTP and inserted into viral DNA The growth of viral DNA gets affected by insertion of nucleotide which causes lack of OH molecule. OH molecules are essential for the formation of 5’ to 3’ phosphodiester linkage which is responsible for chain elongation.

Pharmacokinetic of Abamune 300mg tablet (Abacavir 300mg)

Absorption of Abamune 300mg tablet (Abacavir 300mg)

After oral administration of Abamune 300mg tablet, abacavir and is highly absorbed and its bioavailability occurs at 83% respectively

Distribution of Abamune 300mg tablet (Abacavir 300mg)

Abacavir is highly bound to human plasma protein nearly 50%

Metabolism of Abamune 300mg tablet (Abacavir 300mg)

Abacavir metabolism occurred by alcohol dehydrogenase and glucuronyl transferase.

Elimination of Abamune 300mg tablet (Abacavir 300mg)

The abacavir half life of is 1.54±0.63 hours

Side effects of Abamune 300mg tablet (Abacavir 300mg)

Fatal hypersensitivity reactions, Lactic acidosis and severe hepatomegaly with steatosis, Exacerbations of hepatitis B, Hepatic decompensated in patients co-infected with HIV-I and hepatitis C, Immune reconstitution syndrome, Fat redistribution, Myocardial infraction.
Some common side effects :
Insomnia, depression, headache, fatigue, dizziness, rash, pyrexia, abdominal pain, abnormal pain, anxiety

Precaution of Abamune 300mg tablet (Abacavir 300mg)

Caution with if patients having; Hypersensitivity reactions, lactic acidosis, severe hepatomegaly with steatosis and exacerbations of hepatitis B Fat redistribution, myocardial infarction, hepatic impairment

Drug interaction of Abamune 300mg tablet (Abacavir 300mg)

Zalcitabine, it is not concomitant with Abamune because the effect of lamivudine which is present in the drug and Zalcitabine are inhibits each other. HLA-B*5701 allele not co administered with abacavir due to anaphylactic reactions occurs If taking getting methadone maintenance therapy, with abacavir 600mg twice daily leads to increase the methadone clearance Ethanol blocks the ability of the kidney to eliminate the drug abacavir

Contraindication of Abamune 300mg tablet (Abacavir 300mg)

Abamune 300mg tablet are contraindicated in the patients having HLA-B 5701 allele Hypersensitivity reaction to components present in the product Severe hepatic impairment

Pregnancy of Abamune 300mg tablet (Abacavir 300mg)

Pregnancy category C: Abamune 300mg tablet causes birth defects to unborn babies The use of Abamune in pregnant women may have warrant in use

Lactation of Abamune 300mg tablet (Abacavir 300mg)

Breastfeeding mothers should not take Abamune, it excreted in human milk Nursing mothers not give milk to the babies; it might have chance of postnatal transmission.

Dosage of Abamune 300mg tablet (Abacavir 300mg)

The recommended dose of Abamune 300mg tablet is one tablet of Abacavir 600mg for adult to be taken orally as a single dose, either 300mg twice daily or 600mg once daily in combination with other anti-retroviral medicines with or without food. In pediatric dose: based on body weight The patients weights of 14 to < 20 administer 1 tablet of 300mg given as morning half tablet 150mg and evening half tablet 150mg ≥ 20 to < 25 administered one and half tablets given as morning half tablet of 150mg and evening 1 tablet of 300mg ≥ 25 administer 2 tablets of 600mg given as morning 1 tablet of 300mg and evening 1 tablet of 300mg

Storage of Abamune 300mg tablet (Abacavir 300mg)

The storage condition of Abamune 300mg tablet are at room temperature 20℃ to 25℃ and keep it in dry place

Protect away from moisture, heat, and light.

Missed dose of Abamune 300mg tablet (Abacavir 300mg)

If patient not taken Abamune 300mg tablet , then the dose should be administered within the time The particular missed dose should be skipped and continue the next drug schedule


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Cipla Ltd
30 Tablet
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