Crizotinib 200mg (Crizotinib)
Description of Crizalk 200mg (Crizotinib 200mg)
Crizalk 200mg (Crizotinib 200mg) belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are included in many functions, involving cell development and reproduction.
Crizalk 200mg (Crizotinib 200mg) is made specifically for the treatment of a type of lung cancer in which ALK is overactive due to an abnormality in the ALK gene.
Crizalk 200mg (Crizotinib 200mg) is a prescription medicine which is used under the supervision of medical practioner
Medical use /Indication of Crizalk 200mg (Crizotinib 200mg)
Crizalk 200mg (Crizotinib 200mg) is indicated for the therapy of patients having metastatic non-small cell lung cancer.
Mechanism of Action Crizalk 200mg (Crizotinib 200mg)
Particularly, crizotinibprevents anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteurd'OrigineNantais (RON).
Malformations in the ALK gene result by mutations or translocations may leads expression of oncogenic fusion proteins. somepatients with NSCLC, they have the EML4-ALK gene.
Crizotinib inhibits ALK tyrosine kinase which essentially results in decreasedproliferation of cells which carry the genetic mutation and tumour survivability.
ADME of Crizalk 200mg (Crizotinib 200mg)
Maximum serum concentration is 4 to 6 hours and bioavailability were 43%.
Volume of distribution is 1772L and plasma protein bounding is 91%
Crizalk 200mg (Crizotinib 200mg) metabolised by CYP3A4 and CYP3A5
Crizalk 200mg (Crizotinib 200mg) is eliminated via feces 63% and 22% via urine and half -life is 42 hours
Side effects of Crizalk 200mg (Crizotinib 200mg)
Crizalk 200mg (Crizotinib 200mg) is caused some side effects as follows :
• Infection increased
• Breathlessness
• Eyesight changes
• Bowel changes
• Feeling sick
• Swelling of hands and feet’s
• Decreased appetite
• Fatigue
• Liver changes
• Skin rash
• bradycardia.
Precautions of Crizalk 200mg (Crizotinib 200mg)
Before using Crizalk 200mg (Crizotinib 200mg) in some condition, consult with doctor.
Hepatotoxicity causes while treatment with Crizalk 200mg (Crizotinib 200mg)
while treatment with Crizalk 200mg (Crizotinib 200mg) will causes Interstitial lung disease/pneumonitis.
QT interval prolongation
Bradycardia
Severe visual loss
Embryo-fetal toxicity:
based on mechanism action the meidcine will cause risk to foetus
Drug interaction of Crizalk 200mg (Crizotinib 200mg)
Crizalk 200mg (Crizotinib 200mg) Combination with strong or moderate CYP3A4 inhibitors will increase Crizalk plasma concentration
Crizalk200mg concomitant use with strong CYP3A inducers will decrease Crizalk plasma concentration
Crizalk 200mg (Crizotinib 200mg) Interaction with CYP3A substrates will increase plasma concentration of CYP3A substrates
Do not use combination with bradycardia causing medicine
Pregnancy of Crizalk 200mg (Crizotinib 200mg)
Depends on the studies of animal and mechanism of action, Crizalk 200mg (Crizotinib 200mg) will cause fetal harm when given to pregnant women. Inform the female not to become pregnant while on treatment with Crizalk 200mg (Crizotinib 200mg)
Lactation of Crizalk 200mg (Crizotinib 200mg)
During treatment with Crizalk 200mg (Crizotinib 200mg), advise the women not to breastfed to infants
Dosage of Crizalk 200mg (Crizotinib 200mg)
Crizalk 200 mg taken orally twice daily for First dose reduction
Crizalk 200 mg taken orally once daily for Second dose reduction
Permanently discontinue if unable to tolerate Crizalk 200 mg taken orally once daily.
Dosage and administration :
Select patients for the treatment with Crizalk based on ALK or ROS1 presences in tumor specimens
The usual dosage of Crizalk is 200mg orally twice in a day
Administer the Crizalk dose with or without food, until disease progression.
Storage of Crizalk 200mg (Crizotinib 200mg)
Store at 20℃ to 25℃ in the original container, avoid freeze
Before to administration keep at room temperature
Crizalk 200mg (Crizotinib 200mg) protect from direct light and heat.
Missed dose of Crizalk 200mg (Crizotinib 200mg)
If the patient vomits after taking a dose of Crizalk 200mg (Crizotinib 200mg) or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.
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