Cytogem 1000mg (Gemcitabine)

Gemcitabine
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Dr. Reddy’s Laboratories

Cytogem 1000mg (Gemcitabine)

ManufacturerDr. Reddy’s LaboratoriesBrand nameCytogemInternational trade nameGemzarActive substanceGemcitabineStrength1000mgCategoryAnti Cancer

Description of Cytogem 1000mg (Gemcitabine 1000mg)

Gemcitabine is generic name of brand name Citafine and Gemcitabine is a cancer medicine that inhibits the growth and spread of cancer cells in the body.
Cytogem 1000mg (Gemcitabine 1000mg) administered into a vein by slow injection.
Cytogem 1000mg (Gemcitabine 1000mg) is a prescription medicine which is used under the supervision of medical oncologist

Medical use /Indication of Cytogem 1000mg (Gemcitabine 1000mg)

Cytogem 1000mg (Gemcitabine 1000mg) is indicated for the treatment for Non-small cell lung cancer which is locally advanced or has spread to other areas of the body.

Cytogem 1000mg (Gemcitabine 1000mg) is indicated for the treatment for Cancer of the pancreas which is locally advanced or has spread to other areas of the body.

Cytogem 1000mg (Gemcitabine 1000mg) is indicated for the treatment for Bladder cancer that is locally advanced or has spread to other areas of the body.

Cytogem 1000mg (Gemcitabine 1000mg) is indicated for the treatment for Breast cancer that has returned or spread to other areas of the body and is not suitable for surgery, in people whose cancer has relapsed following previous chemotherapy.

Cytogem 1000mg (Gemcitabine 1000mg) is indicated for the treatment for Ovarian cancer which is locally advanced or has spread to other areas of the body.

Mechanism of Action Cytogem 1000mg (Gemcitabine 1000mg)

Gemcitabine is a family of medicine called antimetabolites which inhibits the DNA production. Antimetabolites are very same to common substances within the cell. This discontinue cell growth and division, reporting in the reducing or blocking of cancer growth. Since cancer cells, in general, replicate faster and with less error-correcting than healthy cells, cancer cells are more conscious to this damage. Gemcitabine kills cancer cells go through DNA synthesis. It interferes with ribonucleotide reductase, an enzyme important to DNA combination. Because cells cannot duplicate their DNA, they cannot properly multiply, and thus die.

ADME of Cytogem 1000mg (Gemcitabine 1000mg)

By infusion length the volume of distribution is increased Vd: 50 L/m2
Metabolized by transformed through nucleoside kinases to two active metabolites such as gemcitabine diphosphate and gemcitabine triphosphate
This medicine is excreted through urine (92-98%) and Half-life of Citafine is 1.7-19.4 hr

Side effects of Cytogem 1000mg (Gemcitabine 1000mg)

Common side effects :

  • Cough.
  • Blocked or runny nose.
  • Sweating.
  • Back pain.
  • Myalgia.
  • Chills and fever.
  • Weakness
  • Loss of appetite.
  • Headache.
  • Insomnia
  • Sleepiness.
  • Mouth ulcers.
  • Diarrhoea or constipation.

Very common side effects :

  • Dyspnea.
  • Alopecia
  • Allergic skin rash.
  • Cold or flu-like symptoms.
  • Retention of fluid in the body
  • Abnormal results in liver function tests.
  • blood in the urine or protein presence

Precautions of Cytogem 1000mg (Gemcitabine 1000mg)

With Cytogem 1000mg (Gemcitabine 1000mg) treatment Capillary leak syndrome resulted with serious consequences; discontinue if symptoms occur
Haemolytic uremic syndrome resulted, containing fatalities; permanently stop treatment in patients with HUS or serious kidney impairment; Kidney failure may not be reversible even with stop of therapy
Medicine-induced liver injury resulted, involving liver failure and death; assess hepatic function before to initiation of therapy and periodically during treatment; stop medicine in patients which develop severe liver injury
When Cytogem 1000mg (Gemcitabine 1000mg) in combination with carboplatin or paclitaxel: patients should have ANC >1.5 x 10^6/mL and platelet count >10^8/mL prior to each cycle

Drug interaction of Cytogem 1000mg (Gemcitabine 1000mg)

No drug interaction studies have been conducted

Contraindication of Cytogem 1000mg (Gemcitabine 1000mg)

Hypersensitivity

Pregnancy of Cytogem 1000mg (Gemcitabine 1000mg)

The Cytogem 1000mg (Gemcitabine 1000mg) Pregnancy category D

When administrated to a pregnant woman will cause fetal harm to the fetus the pregnant women should be apprised of the possible hazard to a fetus.

Lactation of Cytogem 1000mg (Gemcitabine 1000mg)

Avoid breastfeed during this treatment because the medicine Cytogem 1000mg (Gemcitabine 1000mg) may excreted into breast milk

Dosage of Cytogem 1000mg (Gemcitabine 1000mg)

Pancreatic cancer :

The recommended dose is 1000mg/m2 IV infusion over 30 min once weekly x 7 weeks; rest 1 week
And the dose 1000mg/m2IV once weekly for 3 weeks of each 28-day cycle

Non-small cell lung cancer:

The recommended dose is 1000mg/m2IV infusion over 30 minutes on days 1,8 and 15 of each 28-day cycle or
The recommended dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Administer cisplatin 100mg/m2 IV after gemcitabine on day 1

Breast cancer :

The recommended dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Dose with paclitaxel 175mg/m2 on day 1 as a 3-hr infusion before gemcitabine

Ovarian cancer :

The recommended dose is 1000 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle.
Dose with carboplatin AUC 4 on day 1 after gemcitabine

Storage of Cytogem 1000mg (Gemcitabine 1000mg)

The medicine Cytogem 1000mg (Gemcitabine 1000mg) Store at 20 ℃ to 25 ℃ (68 ℃ to 77℉)

Missed dose of Cytogem 1000mg (Gemcitabine 1000mg)

If failed to take dose, then have the missed dose as soon as possible before next dose time reaches or skip the dose and follow the normal schedule
Consult the doctor

Brand name:
Cytogem
International trade name:
Gemzar
Active substance:
Gemcitabine
Strength:
1000mg
Category:
Anti Cancer
Manufacturer:
Dr.Reddy's
Packaging:
1 Vial
Product form:
Injection

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