Duovir (Zidovudine & Lamivudine)

Zidovudine & Lamivudine
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Cipla Ltd

Duovir (Zidovudine & Lamivudine)

ManufacturerCipla LtdBrand nameDuovirActive substanceZidovudine & LamivudineStrength300mg + 150mgCategoryHIVManufacturerCipla Ltd

Description  of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

Duovir (Lamivudine 150mg + Zidovudine 300mg) is a type of antiretroviral drugs which analog to nucleoside polymerase. Duovir (Lamivudine 150mg + Zidovudine 300mg) is a combination drugs of lamivudine 150mg and Zidovudine 300mg. The drug which prevent human immunodeficiency virus (HIV) from multiplying in your body.

INDICATIONS of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

Duovir (Lamivudine 150mg + Zidovudine 300mg) is used for the treatment of HIV-1 infection by combination with other antiretroviral drugs. Duovir (Lamivudine 150mg + Zidovudine 300mg) is a nucleoside analogue with combination of Lamivudine and zidovudine.

MECHANISM OF ACTION  of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

Duovir (Lamivudine 150mg + Zidovudine 300mg) consist of Lamivudine and Zidovudine which is a synthetic nucleoside analogue. Both drugs acts like inside cell Lamivudine and Zidovudine is phosphorylated to its active 5-triphosphate metabolite and forms Zidovudine triphosphate and Lamivudine triphosphate (L-TP). The basic action of L-TP and ZDV-TP is inhibition of reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside correlated.Both L-TP and ZDV-TP is a weak inhibitor of mammalian DNA polymerases a and b, and mitochondrial DNA polymerase g which has been reported to be incorporated into DNA of cells in culture.

Absorption of Duovir (Lamivudine 150mg + Zidovudine 300mg)

Rapidly absorbed from the GI tract. Absorption with food is delayed Bioavailability: 80-87% (Lamivudine); approx 60-70% (zidovudine). Time to peak plasma concentration: Approx 1 hr.


Distribution of Duovir (Lamivudine 150mg + Zidovudine 300mg)
Passes through blood-brain barrier and placenta that enters breast milk and Detected in semen (zidovudine). Volume of distribution: 1.3 L/kg (Lamivudine); 1-2.2 L/kg (zidovudine). Plasma protein binding: Up to 36% (Lamivudine); 34-38% (zidovudine).


Metabolism of Duovir (Lamivudine 150mg + Zidovudine 300mg)
Both regimens are metabolized inside the cells to form the active triphosphate. Zidovudine goes through hepatic metabolism, mainly to the inactive glucuronide.


Elimination of Duovir (Lamivudine 150mg + Zidovudine 300mg)
Lamivudine and zidovudine excreted Via urine, (mainly as unchanged drug) Elimination half-life: 5-7 hr (Lamivudine); 0.5-3 hr (zidovudine).

 SIDE EFFECTS  of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

If dose is missed, patients should consult with medical practitioner & follow their instructions. Continue the regular dosing schedule .Avoid the missed dose if possible. Do not self medicate the drug.
More common:
Chills, fever, pale skin, sore throat weakness, head pain Less common: stomach ache, nausea, skin rash, vomiting, yellow eyes, coughing, l oss of appetite, sleeping trouble.
Incident not known :
blurred vision, dry mouth, hair loss, increased (hunger,thirst,urination), chest discomfort, wheezing, myalgia, convulsions.

PRECAUTION  of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

Monitoring Parameters , Monitor haematological parameters observe for appearance of hardened infections and signs and symptoms of pancreatitis. Periodically check liver function test and for several month following discontinuation of therapy for patients co-infected with hepatitis B virus and HIV. Obese women with hepatomegaly, hepatitis or other risk factors causes liver disease and hepatic steatosis; hepatitis B or C virus co-infection leads risk factors for pancreatitis Patient with poor bone marrow reserve before the treatment. Renal and severe hepatic impairment. Children Pregnancy.

 

DRUG INTERACTION  of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

Duovir (Lamivudine 150mg + Zidovudine 300mg) given with Emtricitabine may develop cross –resistance. Continue use of zidovudine with Ribavirin leads to Excerabtion of anemia. Lamivudine and zalcitabine may prevent intracellularily phosphorylation of one another. Interaction of zidovudine with stavudine and doxorubicin will produce antagonistic effects. Duovir (Lamivudine 150mg + Zidovudine 300mg) used with interferon alfa in HIV may develop risk of hepatic decompenstion.

CONTRAINDICATION  of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

Previously demonstrating clinically significant in patients are hypersensitivity to any of the component of Duovir (Lamivudine 150mg + Zidovudine 300mg). The patient with low body weight should not be receive Duovir (Lamivudine 150mg + Zidovudine 300mg) dose.

PREGNANCY & LACTATION  of Duovir (Lamivudine 150mg + Zidovudine 300mg)

Category C: In Animal reproduction studies have shown adverse effect on fetus while in human there is no adequate and well controlled studies, but probable use may warrant the drug in pregnant women produce possible risk.

Breastfeeding is not recommended while using this drug

 

DOSAGE of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

 

Duovir (Lamivudine 150mg + Zidovudine 300mg) dosage in adults is lamivudine 150mg and zidovudine 300mg with weight of >30kg one tablet twice in a day Childern of 14-21 kg one half tablet bid and for 22-30kg one half tablet in the morning or one half tab tid. Duovir (Lamivudine 150mg + Zidovudine 300mg) may be taken with or without food.


STORAGE  of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

 

Duovir (Lamivudine 150mg + Zidovudine 300mg) stored at 20- 25℃

Keep in cool and dry place

Keep away from children and lights.

Duovir (Lamivudine 150mg + Zidovudine 300mg) should be used before expiry date.

 

MISSED DOSE of  Duovir (Lamivudine 150mg + Zidovudine 300mg)

If dose is missed, patients should consult with medical practitioner & follow their instructions. Continue the regular dosing schedule .Avoid the missed dose if possible. Do not self medicate the drug.

Brand name:
Duovir
Active substance:
Zidovudine & Lamivudine
Strength:
300mg + 150mg
Category:
HIV
Manufacturer:
Cipla Ltd
Packaging:
60 Tablets
Product form:
Tablet

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