Gemtaz 1gm (Gemcitabine)

Gemcitabine
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Sun Pharmaceutical Industries

Gemtaz 1gm (Gemcitabine)

ManufacturerSun Pharmaceutical IndustriesBrand nameGemtazInternational trade nameGemzarActive substanceGemcitabineStrength1gmCategoryAnti Cancer

Description of Gemtaz 1gm (Gemcitabine 1gm)

Gemcitabine is generic name of brand name Citafine and Gemcitabine is a cancer medicine that inhibits the growth and spread of cancer cells in the body.
Gemtaz 1gm (Gemcitabine 1gm) administered into a vein by slow injection.
Gemtaz 1gm (Gemcitabine 1gm) is a prescription medicine which is used under the supervision of medical oncologist

Medical use /Indication of Gemtaz 1gm (Gemcitabine 1gm)

Gemtaz 1gm (Gemcitabine 1gm) is indicated for the treatment for Non-small cell lung cancer which is locally advanced or has spread to other areas of the body.
Gemtaz 1gm (Gemcitabine 1gm) is indicated for the treatment for Cancer of the pancreas which is locally advanced or has spread to other areas of the body.
Gemtaz 1gm (Gemcitabine 1gm) is indicated for the treatment for Bladder cancer that is locally advanced or has spread to other areas of the body.
Gemtaz 1gm (Gemcitabine 1gm) is indicated for the treatment for Breast cancer that has returned or spread to other areas of the body and is not suitable for surgery, in people whose cancer has relapsed following previous chemotherapy.
Gemtaz 1gm (Gemcitabine 1gm) is indicated for the treatment for Ovarian cancer which is locally advanced or has spread to other areas of the body.

Mechanism of Action Gemtaz 1gm (Gemcitabine 1gm)

Gemcitabine is a family of medicines called antimetabolites which inhibits the DNA production. Antimetabolites are very same to common substances within the cell. This discontinue cell growth and division, reporting in the reducing or blocking of cancer growth. Since cancer cells, in general, replicate faster and with less error-correcting than healthy cells, cancer cells are more conscious to this damage. Gemcitabine kills cancer cells go through DNA synthesis. It interferes with ribonucleotide reductase, an enzyme important to DNA combination. Because cells cannot duplicate their DNA, they cannot properly multiply, and thus die.

ADME of Gemtaz 1gm (Gemcitabine 1gm)

By infusion length the volume of distribution is increased Vd: 50 L/m2
Metabolized by transformed through nucleoside kinases to two active metabolites such as gemcitabine diphosphate and gemcitabine triphosphate
The medicine is excreted through urine (92-98%) and Half-life of Citafine is 1.7-19.4 hr

Side effects of Gemtaz 1gm (Gemcitabine 1gm)

Common side effects :

  • Cough.
  • Blocked or runny nose.
  • Sweating.
  • Back pain.
  • Myalgia.
  • Chills and fever.
  • Weakness
  • Loss of appetite.
  • Headache.
  • Insomnia
  • Sleepiness.
  • Mouth ulcers.
  • Diarrhoea or constipation.

Very common side effects :

  • Dyspnea.
  • Alopecia
  • Allergic skin rash.
  • Cold or flu-like symptoms.
  • Retention of fluid in the body
  • Abnormal results in liver function tests.
  • blood in the urine or protein presence

Precautions of Gemtaz 1gm (Gemcitabine 1gm)

With Gemtaz 1gm (Gemcitabine 1gm) treatment Capillary leak syndrome resulted with serious consequences; discontinue if symptoms occur

Haemolytic uremic syndrome resulted, containing fatalities; permanently stop treatment in patients with HUS or serious kidney impairment; Kidney failure may not be reversible even with stop of therapy

medicine-induced liver injury resulted, involving liver failure and death; assess hepatic function before to initiation of therapy and periodically during treatment; stop cedicine in patients which develop severe liver injury

When Gemtaz 1gm (Gemcitabine 1gm) in combination with carboplatin or paclitaxel: patients should have ANC >1.5 x 10^6/mL and platelet count >10^8/mL prior to each cycle

Drug interaction of Gemtaz 1gm (Gemcitabine 1gm)

No medicine interaction studies have been conducted

Contraindication of Gemtaz 1gm (Gemcitabine 1gm)

Hypersensitivity

Pregnancy of Gemtaz 1gm (Gemcitabine 1gm)

The Gemtaz 1gm (Gemcitabine 1gm) Pregnancy category D

When administrated to a pregnant woman will cause fetal harm to the fetus the pregnant women should be apprised of the possible hazard to a fetus.

Lactation of Gemtaz 1gm (Gemcitabine 1gm)

Avoid breastfeed during this treatment because the medicines Gemtaz 1gm (Gemcitabine 1gm) may excreted into breast milk

Dosage of Gemtaz 1gm (Gemcitabine 1gm)

Pancreatic cancer :

The recommended dose is 1000mg/m2 IV infusion over 30 min once weekly x 7 weeks; rest 1 week
And the dose 1000mg/m2IV once weekly for 3 weeks of each 28-day cycle

Non-small cell lung cancer:

The recommended dose is 1000mg/m2IV infusion over 30 minutes on days 1,8 and 15 of each 28-day cycle or

The recommended dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Administer cisplatin 100mg/m2 IV after gemcitabine on day 1

Breast cancer :

The recommended dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Dose with paclitaxel 175mg/m2 on day 1 as a 3-hr infusion before gemcitabine

Ovarian cancer :

The recommended dose is 1000 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle.
Dose with carboplatin AUC 4 on day 1 after gemcitabine

Storage of Gemtaz 1gm (Gemcitabine 1gm)

The medicine Gemtaz 1gm (Gemcitabine 1gm) Store at 20 ℃ to 25 ℃ (68 ℃ to 77℉)

Missed dose of Gemtaz 1gm (Gemcitabine 1gm)

If failed to take dose, then have the missed dose as soon as possible before next dose time reaches or skip the dose and follow the normal schedule
Consult the doctor

Brand name:
Gemtaz
International trade name:
Gemzar
Active substance:
Gemcitabine
Strength:
1gm
Category:
Anti Cancer
Manufacturer:
Sun Pharmaceuticals
Packaging:
1 Vial
Product form:
Injection

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