Hermab 440mg (Trastuzumab)
Description of Hermab 440mg (Trastuzumab 440mg)
Hermab 440mg (Trastuzumab 440mg) is a group of medicines which belongs to anti neoplastics medication. Hermab 440mg (Trastuzumab 440mg) is a chemotherapy drug, the main ingredient which is used as Trastuzumab. It is recommended that Hermab 440mg (Trastuzumab 440mg) be administered under the guidance of a qualified physician experienced in the use of cancer chemotherapeutic agents.
INDICATIONS of Hermab 440mg (Trastuzumab 440mg)
The injection Hermab 440mg (Trastuzumab 440mg) is used alone or combination with other medicine for the treatment in patients who suffering from metastatic breast cancer.
The drug also indicated with combination of other medicine for the treatment of certain types of stomach or esophagus cancer in some persons.
MECHANISM OF ACTION of Hermab 440mg (Trastuzumab 440mg)
Different type of breast cancer cells have a higher than normal level of a protein called HER2 (human epidermal growth factor receptor 2) on their surface. These HER2 receptors get signals which stimulate the tumor cells to develop and reproduce. But breast cancer cells with too many HER2 receptors can Choice too many growth signals and so start developing and proliferating too much and too fast. Hermab 440mg (Trastuzumab 440mg) acts by adhere itself to the HER2 receptors on the surface of breast cancer cells and stopping them from collecting growth signals. By stopping the signals, Hermab 440mg (Trastuzumab 440mg) can slow or inhibit the growth of the breast cancer and the drug is an immune targeted therapy. In addition to inhibiting HER2 receptors, Trastuzumab can also help to fight against breast cancer by attentive the immune system to damage the cancer cells onto which it is attached.
SIDE EFFECTS of Hermab 440mg (Trastuzumab 440mg)
Common side effects:
Redness at injection site (IV)
Mild skin rash
Serious side effects:
Sudden unexplained weight gain
Easy bruising or bleeding
Fast or pounding heartbeat
PRECAUTIONS of Hermab 440mg (Trastuzumab 440mg)
Embryo fetal damage
Hermab 440mg (Trastuzumab 440mg) is contraindicated to pregnancy period. Avoid becoming pregnancy during this therapy. Use efficient contraceptives during treatment
Patient getting Hermab 440mg (Trastuzumab 440mg) injection have increased risk of exposing to cardiac disorders. Provide alternative therapy management In serious condition, treatment should be discontinue
Some serious fatal cases of pulmonary toxicity occur during Hermab 440mg (Trastuzumab 440mg) treatment.
During Hermab 440mg (Trastuzumab 440mg) treatment some life threatening infusion reactions are produced. In serious infusion reactions, Stop the Hermab 440mg (Trastuzumab 440mg) treatment permanently. Patient should be treated with premedication before starting the infusion to overcome the such problem, During Hermab 440mg (Trastuzumab 440mg) treatment.use with Caution.
Therapy induced neutropenia
Higher incidence of neutropenia occurs during Hermab 440mg (Trastuzumab 440mg) treatment.
DRUG INTERACTION of Hermab 440mg (Trastuzumab 440mg)
In some phenomenal condition, patient should get anthracycline, in that situation patient’s cardiac function should be checked carefully with regular intervals. Do not take anthracycline treatment for 7 months after stopping the Hermab 440mg (Trastuzumab 440mg) treatment. Hermab 440mg (Trastuzumab 440mg) interaction with anthracycline after ending of Hermab 440mg (Trastuzumab 440mg) treatment may have a chance of getting cardiac problem. This side effects occur because of Trastuzumab great disaster period is depends on population PK analysis.
CONTRAINDICATION of Cytotam 10mg (Tamoxifen 10mg)
Probably no contraindicated occurs. The patients are contraindicated to the component present in the Hermab 440mg (Trastuzumab 440mg), Hence Hypersensitivity reactions are occurs.
PREGNANCY & LACTATION of Hermab 440mg (Trastuzumab 440mg)
Normally, if you are pregnant and administrating Hermab 440mg (Trastuzumab 440mg) injection, one of your greatest worry will be for your unborn child. Because, during pregnancy this cancer medicine may be harmful for your baby. So, if this drug is used during pregnancy, or if the patient becomes pregnant while taking this medicine, the patient should be advice about the hidden hazard to a fetus. You should tell about your pregnancy to your doctor. Your pharmacist must understand your condition in order to check your health, and then your baby will be protected from infection soon after birth. You can also discuss with your doctor about birth control methods that will work for you.
DOSAGE of Hermab 440mg (Trastuzumab 440mg)
The injection Hermab 440mg (Trastuzumab 440mg) should not mix with other drugs and do not administer as an intravenous push or bolus. Trastuzumab should not be substitute for or with ado-Trastuzumab emtansine
Adjuvant treatment, breast cancer : The drug given according to one of the following doses and schedules for a 52 weeks total of trastuzumab treatment:
During combination with paclitaxel, docetaxel, or docetaxel /Carboplatin:
Starting dose of 4 mg/kg as an IV (intravenous infusion) over 90 minutes followed at 2 mg/kg as an IV( intravenous infusion) over 30 minutes weekly during treatment of chemotherapy given with paclitaxel or docetaxel for first 12 weeks or 18 weeks (docetaxel/carboplatin) The Hermab 440mg (Trastuzumab 440mg) dose for One week following the last weekly administers Trastuzumab at 6 mg/kg as an IV (intravenous infusion) over 30 to 90 minutes every three weeks. The injection given as a single agent within three weeks following completion of multi-modality,
anthracycline-based chemotherapy regimens: For an intravenous infusion over 90 minutes: Initial dose at 8 mg/kg Successive doses at 6 mg/kg over 30 to 90 minutes every three weeks as an intravenous infusion. Adjuvant treatment stretching beyond one year is not recommended.
Metastatic Treatment, Breast Cancer: Hermab 440mg (Trastuzumab 440mg) administrated alone or in combination with paclitaxel, at an starting dose of 4 mg/kg as a 90-minute intravenous infusion continued by successive once weekly doses of 2 mg/kg as 30-minute intravenous infusions until disease development.
Metastatic Gastric Cancer: Hermab 440mg (Trastuzumab 440mg) administrated at an starting dose of 8 mg/kg as a 90 minute IV intravenous infusion continued by successive doses of 6 mg/kg as an intravenous infusion over 30 to 90 minutes every three weeks until disease development.
STORAGE of Hermab 440mg (Trastuzumab 440mg)
Store the drug at 2℃ to 8℃ (refrigerator temperature) Protected the vial away from heat & light Stored at 2℃ to 8℃ for 28 days after reconstitution Stored Hermab 440mg (Trastuzumab 440mg) diluted bag at 2℃ to 8℃ for 24 hours.
The drug Missing doses can decrease their usefulness and raises the probability of developing drug resistance, that makes this drug lose their potency. For best results, it is important to accept each scheduled dose of Trastuzumab medication as instructed. If you miss a dose, leave the missed dose and continue with your regular dosing schedule. Do not have two doses to make up for a missed one. If you are not sure about what to do after missing a dose, the take advice with doctor or pharmacist.
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