Oncothal 100mg (Thalidomide)

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Brand nameOncothalInternational trade nameThalomidActive substanceThalidomideStrength100mgCategoryAnti Cancer

Description of Oncothal 50mg (Thalidomide 50mg)

Thalidomide is a generic of brand name of Oncothal 100mg (Thalidomide 100mg).
Oncothal 100mg (Thalidomide 100mg) appeared as a hopeful alternative to barbiturates which were then needed as sedatives, because it didn’t seem to be toxic nor have any side effects. The overdose would only cause deep sleep, as hostile to barbiturates which could cause death if taken in more quantity.It has been renewing and indicated for several immunological and inflammatory disorders. Oncothal 100mg (Thalidomide 100mg) displays immunosuppressive and anti-angiogenic activity. It prevents release of tumor necrosis factor-alpha from monocytes and modulates another cytokine action

Medical use /Indication of Oncothal 50mg (Thalidomide 50mg)

Oncothal 100mg (Thalidomide 100mg) is indicated for treatment of skin lesions associated with leprosy. Oncothal 100mg (Thalidomide 100mg) is indicated in various cancer conditions such as: multiple myeloma, renal cell carcinoma, glioblastoma multiforme and Waldenström macroglobulinemia. As well as treatment of graft vs. host disease (GVHD) after bone marrow transplant.

Mechanism of Action Oncothal 50mg (Thalidomide 50mg)

Extra, thalidomide is known to have different effects on the immune system (immunomodulatory agent), which may provide to its healing effect. Thalidomide may also change the production and activity of cytokines (growth factors) contains in the growth and durability of certain cancer cells. There may be an effect on the genes which direct the cell's development and activity specifically those along with cytokines (growth factors), apoptosis (cell death), and metabolism.

Absorption of Oncothal 50mg (Thalidomide 50mg)

Time to peak plasma concentration is 2.9 to 5.7 hours

Distribution of Oncothal 50mg (Thalidomide 50mg)

plasma protein binding is 55% and 66% for the (+) R and (-) S enantiomers, respectively

Metabolism of Oncothal 50mg (Thalidomide 50mg)

Metabolized hepatically by enzymes of the cytochrome P450 enzyme system

Excretion of Oncothal 50mg (Thalidomide 50mg)

Excreted in the urine as unchanged medicine is less than 0.7% of the dose.

Half-life of thalidomide is 5 to 7 hours.

Side effects of Oncothal 50mg (Thalidomide 50mg)

  • Neutropenia
  • Thrombocytopenia
  • Increased HIV viral load
  • Bradycardia
  • Seizures
  • Tumor Lysis
  • Hypersensitivity
  • Teratogenicity
  • Venous and arterial thromboembolism
  • Increased Mortality
  • Drowsiness and somnolence
  • Peripheral neuropathy
  • Dizziness and orthostatic hypotension

Precautions of Oncothal 50mg (Thalidomide 50mg)

For both men and women use contraceptives, and do not conceive a child (get pregnant) while taking Oncothal 100mg (Thalidomide 100mg). serious, life-threatening birth defects may have reported with even one 50 mg dose. Methods of contraception has two types, such as latex condoms and spermicides, are required.

For women of childbearing potential should use contraception 4 weeks before you can start Oncothal 100mg (Thalidomide 100mg). The manufacturer needed you to take a pregnancy test every month before you initiate a new prescription of thalidomide. This is to confirm that you or your significant other is not pregnant. Consult with your doctor when you may safely become pregnant or conceive a child after treatment.

Prior initiating Oncothal 100mg (Thalidomide 100mg) treatment, make sure to inform doctor about any other medications you are taking (containing prescription, over-the-counter, vitamins, herbal remedies, etc.). Avoid taking aspirin, or products including aspirin untilthe doctor especially permits this.

Avoid taking regimens that may cause drowsiness without first consulting your health care provider. Also avoid alcohol.

Do not breast feed while taking this medication.

Drug interaction of Oncothal 50mg (Thalidomide 50mg)

Combination of Oncothal 100mg (Thalidomide 100mg)  with opioids, antihistamines, antipsychotics, anti-anxiety agents, other CNS depressants may lead to additive sedative effect.

Concomitant use of Oncothal 100mg (Thalidomide 100mg)  with cardiovascular medication will cause an additive bradycardic effect and should be used with caution. Interaction with bortezomib, amiodarone, cisplatin, docetaxel, paclitaxel, vincristine etc will cause peripheral neuropathy and should be used with caution.

Unknown condition when concomitant use of hormonal contraceptives further increases the risk of thromboembolism with Oncothal 100mg (Thalidomide 100mg)

Contraindication of Oncothal 50mg (Thalidomide 50mg)


Pregnancy - the medicine cause risk to fetal

Pregnancy of Oncothal 50mg (Thalidomide 50mg)

Pregnancy category X: Oncothal 100mg (Thalidomide 100mg) may cause risk to fetal when administer to a pregnant woman. This medicine should not administer to a pregnant woman or a woman who aims to become pregnant.

Lactation of Oncothal 50mg (Thalidomide 50mg)

There has no data available for the presence of Oncothal 100mg (Thalidomide 100mg) in human milk and effects of medicine on breastfed infants.

Avoid breastfeeding during treatment with Oncothal 100mg (Thalidomide 100mg) 100mg

Dosage of Oncothal 50mg (Thalidomide 50mg)

Chronic Immune Thrombocytopenia

The recommended dose of Revolade has Initial: 50 mg PO qDay Adjust dose to achieve Control platelet count (Plt) >50 x 10^9/L to reduces risk of bleeding; not to exceed 75 mg/day

Chronic Hepatitis C-associated Thrombocytopenia

The recommended dose of Revolade has Initial: 25 mg PO qDay Dose is Adjust in 25 mg accretion q2weeks PRN to attain target Plt needed to start/control antiviral therapy with pegylated interferon and ribavirin; not to exceed 100 mg/day During antiviral therapy, regulate dose to stop dose reductions of peginterferon Severe Aplastic Anemia

First-line therapy: Concomitant use with standard immunosuppressive therapy, for patients with serious aplastic Anemia (SAA) The recommended dose of Revolade: 150 mg PO qDay for 6 months Do not give more than starting dose; total duration is 6 months

Refractory SAA

The medicine given for this condition who fail to respond enough to at least 1 before immunosuppressive therapy The recommended dose of Revolade: 50 mg PO qDay Adjust dose in 50-mg accretion q2Weeks PRN to attain target Plt ≥50 x 10^9/L as required; not exceed 150 mg/day; may take up to 16 weeks for hematologic response.

Storage of Oncothal 50mg (Thalidomide 50mg)

Store at 20℃ - 25℃.

Protect the medicine from light

Missed dose of Oncothal 50mg (Thalidomide 50mg)

Take the dose immediately before next dose duration. Next dose time reaches then left off the missed dose and continue regular schedule. Avoid taking double dose at same time.

Please consult the doctor for further information.

Brand name:
International trade name:
Active substance:
Anti Cancer
Cadila Pharmaceuticals
10 Capsules
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