Ritomune 100mg (Ritonavir)

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Cipla Ltd

Ritomune 100mg (Ritonavir)

ManufacturerCipla LtdBrand nameRitomuneInternational trade nameNorvir Active substanceRitonavirStrength100mgCategoryHIV

Description of Ritomune 100mg (Ritonavir 100mg)

Ritomune 100mg (Ritonavir 100mg) is sold under the brand name of Ritomune 100mg (Ritonavir 100mg) tablets and it anti-retroviral drug. Ritomune 100mg (Ritonavir 100mg) is also a CYP3A inhibitor Ritomune 100mg (Ritonavir 100mg) is classified as HIV protease inhibitor drug, which is peptidomimetic agent containing both HIV-1 & HIV-2 protease inhibitor activity. Ritomune 100mg (Ritonavir 100mg) is exhibits anti-retroviral activity by interceding with reproductive cycles of HIV.

Medical use /Indication of Ritomune 100mg (Ritonavir 100mg)

Ritomune 100mg (Ritonavir 100mg) tablets are widely indicated for treating HIV-1 infection by combining with other anti-retroviral medications.

Mechanism of Action Ritomune 100mg (Ritonavir 100mg)

HIV protease enzymes which is involves in separation of structural & multiplicative proteins that may produce from major HIV genes, like gag & pol. This activity of enzyme should be reduced due to inhibiting the protease enzyme by ritonavir, an active substance of Ritomune 100mg (Ritonavir 100mg) tablets. Gal: conceal the proteins complicated in core & nucleocapsid. Pol: conceal the reverse transcriptase, ribonuclease H, integrase & protease. The separation of gal-pal polyprotein should be prevented by ritonavir which leads to production of immature and non infectious viral particles.

Side effects of Ritomune 100mg (Ritonavir 100mg)

Edema, Gout, Increased cholesterol, Increased triglycerides Liver toxicity, Pancreatitis, Allergic reactions, Blurred vision, Abdominal pain, Hypersensitivity reactions, Lipodystrophy, Arthralgia, Myopathy, Dyspepsia, Flatulence, GI hemorrhage, Gastro esophageal reflux disease, Nausea, Vomiting, Fatigue, Increased bilirubin, Hepatitis, Myalgia, Acne, Pruritus, Rash, Flushing, Hypertension, Hematocrit, Decreased hemoglobulin, Neutropenia, Dehydration, Cushing’s syndrome, Cardiac problems, Epidermal necrolysis.

Precautions of Ritomune 100mg (Ritonavir 100mg)

Serious adverse reactions may occur due to drug interactions like Ritomune 100mg (Ritonavir 100mg) with CYP3A inducers or inhibitors Hepatic toxicity Pancreatitis Allergic reactions PR interval extension Lipid disorders Diabetes mellitus Immune reconstitution syndrome Fat redistribution Hemophilia Cross resistance These are all some serious effects occurred during the therapy with Ritomune 100mg (Ritonavir 100mg), to over come the problems patients must be; Provide with supportive measures Counsel about the adverse effect before starting the treatment In severe condition, stop the treatment. Maintain the lab value Patient should be frequently monitoring with the signs & symptoms associated to particular effects.

Drug interaction of Ritomune 100mg (Ritonavir 100mg)

Interaction of drugs which are metabolized by CYP3A causes increasing the plasma concentration of these agents. Interaction of Ritomune 100mg (Ritonavir 100mg) with HIV-1 protease inhibitors causes increasing effect of concentration of these drugs. Ritomune 100mg (Ritonavir 100mg) interaction with integrase inhibitors, causes decreasing the effect of concentration of these drugs. Concomitant use with analgesic causes increasing concentration of analgesics. Ritomune 100mg (Ritonavir 100mg) interaction with anti-cancer or anti-arrhythmic drugs causes increasing the effect of concentration of these drugs. Interaction of Ritomune 100mg (Ritonavir 100mg) with warfarin causes either decreasing or increasing the concentration of warfarin. Interaction of Ritomune 100mg (Ritonavir 100mg) with anti-convulsants, anti-depressants causes increasing in concentration of these drugs .

Over dosage of Ritomune 100mg (Ritonavir 100mg)

No special antidote is required for over dosage If occurs then Provide patients supportive measure to the patient with over dosage of Ritonavir. Monitor the manifestation associated to over dosage condition of Ritomune 100mg (Ritonavir 100mg). Ritonavir is intensively metabolized and largely binds to human plasma protein so hemodialysis process is not valuable for over dosage of ritonavir.

Pregnancy & Lactation of Ritomune 100mg (Ritonavir 100mg)

Pregnancy category C Ritomune 100mg (Ritonavir 100mg) should not be used in pregnancy & lactating period.

Generally HIV infected women should not undergo breast feeding, for avoiding the spreadness of disease to baby.

Dosage of Ritomune 100mg (Ritonavir 100mg)

The prescribed doses of Ritomune 100mg (Ritonavir 100mg) for adults are; 600mg should be administered orally as two times a day. Ritomune 100mg (Ritonavir 100mg) tablets should be initiated by not less than 300mg as two times a day followed by increased dose at 2 to 3 days by 100mg as twice daily. The maximum dose is 600mg and it should not be exceeded. For pediatric; Ritomune 100mg (Ritonavir 100mg) should be used by combining with other antiretroviral drugs. The prescribed dose of Ritomune 100mg (Ritonavir 100mg) is 350 to 400mg/m2 as two times a day for pediatric patients with age of older than 1 month. The dose should not be exceeded to 600mg The initial dose of Ritomune 100mg (Ritonavir 100mg) is 250mg/m2 two times day and increased at 2 to 3 days interal by 50mg/m2 as two times a day. Depending on body surface area, the dose should be calculated. Dose reduction is required when Ritomune 100mg (Ritonavir 100mg) is combined with atazanavir, darunavir, fosamprenavir, saquinavir & tipranavir.

Storage of Ritomune 100mg (Ritonavir 100mg)

Ritomune 100mg (Ritonavir 100mg) tablet container should be stored on below 30℃. Keep the container away from heat, moisture & light.

Missed dose of Ritomune 100mg (Ritonavir 100mg)

Patient must get advice from physician to avoid the over dosage problem, in case of missed dose. Follow the regular dosing schedule prescribed by physician.

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