Sunitinib 25mg (Sunitinib)

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Brand nameSutentInternational trade nameSutentActive substanceSunitinibStrength25mgCategoryAnti Cancer

Description of Sutent 25mg (Sunitinib 25mg)

Sutent 25mg (Sunitinib 25mg) is an antineoplastic Medicine which prevents the growth and spread of cancer cells in the body.

Sutent 25mg (Sunitinib 25mg) belongs to targeted therapy and is a receptor protein-tyrosine kinase inhibitor. It prohibits the actions of vascular endothelial growth factor (VEGF) and is an angiogenesis inhibitor.

Sutent 25mg (Sunitinib 25mg) is a prescription Medicines which is used under the guidance of medical practioners

Medical use /Indication of Sutent 25mg (Sunitinib 25mg)

Sutent 25mg (Sunitinib 25mg) is used for the treatment in patients having Gastrointestinal stromal tumor

Sutent 25mg (Sunitinib 25mg) is used for the treatment in patients having Advanced pancreatic neuroendocrine tumor

Sutent 25mg (Sunitinib 25mg) is used for the treatment in patients having Advanced renal cell cancer

MECHANISM OF ACTION  of  Sutent 25mg (Sunitinib 25mg)

Sunitinib belong to type of small molecule which prohibits multiple RTKs, some of which are involved in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. Sunitinib was judge for its inhibitory activity against a variety of kinases (>80 kinases) and was identified as an inhibitor of platelet-derived growth factor receptors (PDGFRa and PDGFRb), vascular endothelial growth factor receptors (VEGFR1, VEGFR2 and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony stimulating factor receptor Type 1 (CSF-1R), and the glial cell-line derived neurotrophic factor receptor (RET)

ADME of Sutent 25mg (Sunitinib 25mg)

  • High plasma concentration of sunitinib is between 6 and 12 hours and the bioavailability of sunitinib has no effect on food.
  • Human plasma protein binding was 95 % and 90 % respectively.
  • Primarily metabolized by cytochrome P450 enzyme, CYP3A4
  • The Medicine sunitinib is eliminated primarily through feces 61% and renal excretion is 16% of administrated dose. Sunitinib half-life is 40 – 60 hours
  • Primary active metabolite half-life was 80 – 110 hours

Side effects of Sutent 25mg (Sunitinib 25mg)

Common side effects :

Signs of allergic reactions:

hives, breathing difficulty, sore throat, skin pain, red or purple skin rash

Liver problem:

upper stomach pain, itching, tried feeling, decreased appetite, dark urine, jaundice.

Serious side effects :

  • Swelling in ankles or feet
  • Fast heart beats
  • Sudden dizziness
  • Shortness of breath
  • Unusual bruising

Signs of tumor cell breakdown - muscle cramps, tiredness, decreased urination, slow heart rate.

Thyroid problem - severe tiredness, depression, rapid heart rate, , feeling nervous, sweating, nausea, vomiting, diarrhea, loss of hair, weight changes, irregular menstrual periods.

Precautions of Sutent 25mg (Sunitinib 25mg)

  • Adrenal haemorrhage resulted in animal studies; follow the adrenal function in case of stress such as surgery, trauma or severe infection
  • Control urine protein; interfere with treatment for 24-hr urine protein ≥3 g; stop for repeat episodes of protein ≥3 g despite dose reductions or nephrotic syndrome
  • Sutent 25mg (Sunitinib 25mg)treatment will causes severe hepatotoxicity involving liver failure; check liver function tests before starting treatment.
  • Haemorrhagic events involving tumor-related haemorrhage resulted; test the serial complete blood counts and physical examinations
  • Hypothyroidism resulted; follow the baseline thyroid function in patients with hypothyroidism or hyperthyroidism and treat per standard medical practice prior to initiating therapy

Drug interaction of Sutent 25mg (Sunitinib 25mg)

Sutent 25mg (Sunitinib 25mg) combination with CYP3A4 inhibitors (ketoconazole0 will increase the sunitinib plasma concentrations.
Sutent 25mg (Sunitinib 25mg) combination with CYP3A4 inducers (rifampin) will decrease Sunitinib plasma concentration

Contraindication of Sutent 25mg (Sunitinib 25mg)

Patients are contraindicated with Sutent 25mg (Sunitinib 25mg) due to hypersensitivity and renal impairment.

Pregnancy of Sutent 25mg (Sunitinib 25mg)

Advise females of reproductive possible of the probable hazard to a fetus and use of effective contraception.

Lactation of Sutent 25mg (Sunitinib 25mg)

Decision should be taken about discontinue the nursing or to stop the Medicine considering the important of the Medicine to the mother. Hence avoid breast feeding during treatment.

Dosage of Sutent 25mg (Sunitinib 25mg)

The recommended dosage for following condition as follows :

  • Dose after disease progression on or intolerance to imatinib mesylate
  • The usual dose for patients with Gastrointestinal Stromal Tumor is 50 mg PO qDay for 4 weeks, followed by 2 weeks Medicine-free, repeat cycle
  • The usual dose for patients with Renal Cell Carcinomais 50 mg PO qDay for 4 weeks, followed by 2 weeks Medicine-free, repeat cycle

Adjuvant treatment of RCC :

  • Used for the adjuvant therapy of adult patients at high risk of recurrent RCC following nephrectomy
  • The recommended dose is 50 mg PO qDay for 4 weeks, followed by 2 weeks Medicine-free, repeat cycle for a maximum of nine 6-week cycles totally

The usual dose for patients with Pancreatic Neuroendocrine Tumor

is 37.5 mg PO qDay continuously without a scheduled off-treatment period

Storage of Sutent 25mg (Sunitinib 25mg)

  • Stored at controlled temperature at 25℃
  • Keep away from children’s resistance
  • Dispense only in its original carton

Missed dose of Sutent 25mg (Sunitinib 25mg)

If dose is missed the have the dose immediately before next dose timing reaches or skip the missed dose and continue the regular schedule.
Consult doctors regarding missed dose.

Brand name:
International trade name:
Active substance:
Anti Cancer
28 capsules
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