Trade name : Arimidex
Active ingredient : Anastrazole
Strength availability : 1MG
Manufactured by : AstraZeneca
Package : 28 tablets in a carton
Arimidex tablets belongs to classification of anticancer drugs and it contains active constituents like anastrazole. Anastrazole is identify as non-steroidal Aromatase inhibitor. And which available in the form of tablet. Arimidex is able to reduce the estrogen production by preventing Aromatase, an enzyme essential for changes of androgen into estrogen. Anastrazole which involves in hormonal treatment. It is prescription drugs which is used under the guidance of pharmacist, the main ingredient which is used as anastrozole.
Arimidex tablets are used in patients for supporting treatment of postmenopausal women with hormone receptor positive breast cancer. Arimidex is used for treatment of patients require for first line therapy in post menopausal women having receptor positive or hormone receptor exotic locally progressive or metastatic breast carcinoma Arimidex tablets used for treatment of patients require for second line therapy in patients having metastatic breast cancer, in post menopausal women with cancer advancement consequently tamoxifen treatment. Treatment intermittently perform to Arimidex tablets in Patients with hormone receptor negative disorder, or patient who are not respond to tamoxifen .
In adult for the treatment of breast cancer:
Arimidex 1mg recommended dose is one tablet of 1mg, taken once a day, Administrated orally with or without food
Patients having postmenopausal women with hormone receptor +ve in adjuvant treatment in early invasive breast cancer. Duration of treatment is 5 years.
In pediatric patients for the treatment of breast cancer: Arimidex tablet is not used and no inadequate data on safety and efficacy. Arimidex should be followed for five years in ATAC trials
In renal impairment patients or for elderly patients no dose adjustments acquired
In mild to moderate hepatic impairment condition no dose adjustment takes place.
MECHANISM OF ACTION
Anastrazole concurrently prohibits an enzyme Aromatase which helped for converting of ambient estrogen to estrone via adrenally growth androstenedione by Aromatase in peripheral tissues Hence the drug prevent Aromatase may cause decrease in plasma and tumor accumulation of estrogen, following to reducing of tumor lump or slow the development of tumor growth
The drug absorbs rapidly and obtain maximum serum concentration occurs within 2 hours. Effects of food: Reduces food rate but not all the extent of anastrazole absorption.
The drug anastrazole has human serum protein bound is 40%
The anastrazole metabolism is occurred via N-Dealkylation, hydroxylation and Glucuronidation The metabolites of anastrazole are; Triazole-major circulating metabolite which has poor pharmacological activity A glucoronide conjugate of hydroxyl anastrazole A glucoronide conjugate of anastrazole
Nearly 85% of anastrazole reclaimed in feces and urine in Hepatic metabolism: 10% total clearance in Renal metabolism The anastrazole half life is 50 hours
Arimidex tablet will change the effect of other drugs, it concluded as CYP-450 prohibition. While tamoxifen combination with anastrazole will reduce the plasma concentration of anastrazole by 27%. Avoid continuse use with Arimidex tablet which may cause depletion of its pharmacological activity in Estrogen therapy. Concomitant use of Warfarin with anastrazole, it did not alter the anti-coagulant effect.
The patient administrating with tamoxifen may have increase in serum cholesterol level correlated by Arimidex tablets Condition of ischemic cardiovascular action: There is a chance of raising of proportion of ischemic cardiovascular effects while getting Arimidex tablets. When patients getting Arimidex tablet have chance of getting Cholesterol due to lowering total hip bone density and lumbar spine density
The dose missed by patient should have the dose immediately before the next dose timing reaches , or leave the missed dose and continue the regular schedule. Remember do not have double dose at a time Please consult with doctor for further details.
Pregnancy category of anastrazole: X While using Arimidex 1mg the animal or human studies shown fetal abnormalities and unsafe to use the drug during pregnancy clearly. The drug Arimidex while using in pregnant women or to become pregnant is contraindicated.
Neoplasm, Pain , back pain, headache, abdominal pain, infection, injury, , chest pain, Asthenia, , cyst, flu like syndrome
Cardiovascular: Vasodilatation, hypertension
Digestive: Nausea, constipation, diarrhea, dyspepsia, GI disorders
Blood related effects: Lymph edema, anemia
Metabolism: Peripheral edema, weight gain, hypercholesterolemia
Musculoskeletal: Arthritis, arthralgia, osteoporosis, fracture, bone pain, arthrosis, joint pain, Myalgia
Nervous: Depression, insomnia, dizziness, anxiety, paresthesia
Respiratory: Pharyngitis, cough increased, dyspnea, sinusitis, bronchitis
Skin: Rashes, sweating
Eye: Cataract specified
Urogenital:, urinary tract infection, breast pain, breast neoplasm, vulvovaginitis, vaginal hemorrhage,
vaginitis ; Leucorrhea