Trade name : Atavir
Generic : Atazanavir
Strength availability : 300mg
Manufactured by : cipla
Package : 30 tablets
Category : Anti-retroviral agent


Atavir consist of a peak composition known as Atazanavir, it is an anti-retroviral agent. Anti-retroviral property of the drug Atazanavir demostrated by prevention of the protease enzyme activity. It works by decreasing the amount of HIV virus in blood by interfering with maturation of cells. Atavir is not a monotherapy; it may combine with other anti-retroviral medicines like Ritonavir. Atavir tablet is a prescription medicine;


Atavir is an anti retroviral drugs indicated for the treatment of HIV type I infection. Atavir helps to decrease the amount of HIV virus in blood. It lowers the chance of getting AIDS


Atavir is a belongs to a protease inhibitor, this enzyme includes in cleavage of viral polyprotein Atavir is competent against HIV type I infection, it prohibits the cleavage of Gag-Pol polyprotein. This prevention occurs by Atazanavir active form of Atavir, link to protease enzyme and blocks the action produced by that appropriate enzyme So the prevention of cleavage causes to formation of immature cells.


In adults:

HIV-1 infection

Treatment naive :
Atavir is concomitant use with other anti-retroviral medicine like, Ritonavir The usual dose is 300mg should be given orally as a single dose with Ritonavir 100mg If patient taking Ritonavir is not able to tolerate, 400mg of Atavir should be taken once a day with food While combination of Efavirenz with Atavir: 400mg PO with 100mg ritonavir qDay
Treatment experienced :
prescribed dose is 300mg orally as a single dose concomitant use with H2 receptor antagonist and Tenofovir is administeres 400mg PO with 100mg ritonavir qDay
Hepatic impairment :
For Mild hepatic impairment is given 400mg PO qDay For Moderate hepatic impairment is 300mg PO qDay Severe: not recommended
Renal impairment :
300mg PO with 100mg ritonavir qDay for Final stage of renal disease hemodialysis: In pediatric: 6-18 years (treatment naïve and treatment experienced) Atavir is not recommended for <15kg: 200mg PO with 100mg ritonavir qDay for 15kg to <35kg weighing patients 300mg PO with 100mg ritonavir qDay for ≥35kg ≥13 years (patient non tolerated to ritonavir) 400mg PO qDay for patient weighing ≥40kg


Absorption: The high serum concentration of the drug Atazanavir is occurred within 2.5 hours
Distribution: Highly bound to human plasma protein of Atavir (atazanavir) at nearly 86%. If Atavir taken with food, it may raises the bioavailability and decrease pharmacokinetic variability.
Metabolism :
In liver Atavir is largely metabolized and the two major biotransformation pathways in Atavir is Mono-oxygenation Di-oxygenation
Elimination :
The excretion exist via feces and urine. The Atavir half life of the drug is approximately 6 hours.


Atavir interaction with proton pump inhibitor should not used in treatment experienced patients. if patient getting severe rash or other anaphylactic reactions tablet Atavir should be stop Caution should be taken in case of Hepatic impairment Renal impairment High bilirubin levels


Atavir interaction with some of the list; Carbamazepine, lovastatin, Alfuzosin, astemizole, , Cisapride, Cobimetinib, dihydroergotamine, ivabradine, simvastatin, , pimozide, Phenobarbital, phenytoin, rifampin, sildenafil etc


Patients are contraindicated to the ingredients present in the Atavir tablet Anaphylactic reaction occurs Atavir is contraindicated in the conditions; Chronic hepatitis B, C Diabetes Lactic acidosis Hemophilia Gallstones Kidney impairment High amount of bilirubin


if patient fail to administer the dose, advice them to take within a time. Otherwise the missed dose should be skipped and follow the regular drug schedule


>10% :
Total bilirubin level elevated Fever Rash Increased cholesterol Nausea CPK increased Cough Diarrhea Neutrophils counts depleted Jaundice Headache Peripheral neuropathy Insomnia Myalgia Abdominal pain Depression Dizziness Vomiting Prolonged PR interval Diabetes mellitus Edema QTc prolongation, pancreatitis, hepatic function abnormalities, cholelithiasis, arthralgia, alopecia

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