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azithromycin-500mg

PRODUCT DETAILS

Composition : Azithromycin
Strength availability : 500mg
Dosage Form : Tablet
Packing : Pack of 30 tablets
Category : Anti-viral drug
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Azithral 500mg belongs to semi- synthetic macrolide antibiotic which fights against bacteria and its belongs to the class of Azalide.. Azithral 500mg is a white crystalline powder and as the dehydrate.

INDICATION

→ Azithral 500mg is also used to prevent disseminated Mycobacterium avium complex (MAC) infection
→ Infection of the ears, lungs, sinuses, throat and reproductive organs.
→ Azithral 500mg is indicated for the treatment of certain bacterial infections such as
• bronchitis
• Pneumonia
• Sexually transmitted disease (STD)

DOSAGE

For oral dosage form
In adults for bacterial infections
500 to 2000mg once daily, administer as single dose, this may continue with 250 to 500mg dose once daily for several days
For pharyngitis or tonsillitis: 500mg on day 1 taken as single dose followed by 250mg on 2nd day through 5th day
In children’s for infections (6months age – older): based on body weight is dose and must be determined by your doctor.
10 to 30mg/kg of body weight once daily, taken as a single dose.
Based on the type of infection ,continue with doses of 5 to 10 mg/kg of body weight once daily for several days.
Infants < 6 months: discuss with doctor
For pharyngitis or tonsillitis: based on body weight: 12mg/kg of body weight once daily for 5 days
< 2yrs children’s : discuss with doctor for dose.
OVERDOSE: If dose administer higher than prescribed dose will cause nausea, diarrhea, vomiting. If it occurs then provide general symptomatic and supportive measures are indicated as needed

MECHANISM OF ACTION

Azithral 500mg belongs to semisynthetic azalide antibiotic. It prohibits transpeptidation by connecting to 50s ribosomal subunit of affected organisms and disorganize RNA-dependent protein synthesis at the chain expansion step.

PHARMACOLOGICAL

Absorption : Fastly absorbed from the GI tract. Decreased by food (capsule formulation). bioavailability: Approx 34-52%.
Duration of high plasma concentration: Oral tab: 2-3 hr;
Distribution: Volume of distribution: 31-33 L/kg.
Plasma protein binding (based on concentration): 7-51% (oral and IV). Metabolism: Metabolism occur in Hepatic through demethylation.
Elimination: Through bile (as unchanged drug and inactive metabolites); urine (approx 6% of oral dose). Terminal elimination half-life: 68 hr.

DRUG INTERACTION

→ Concomitant use of Azithral 500mg with Nelfinavir will increases azithromycin serum concentrations.
→ Interaction ofAzithral 500mg with Warfarin causes Prothrombin times should be carefully monitored while patients getting continues azithromycin and oral anticoagulants
→ Azithral 500mg combination with Macrolides leads to Serum concentration of macrolides may increased when combined with Azithromycin

WARNING & PRECAUTIONS

• While use of antibacterial agents will cause mild diarrhea to fatal colitis and it alters the normal colon flora results overgrowth of C.difficile. These will produce toxin A and Toxin B leads to development of CDAD and hence increases morbidity and mortality. Before using Azithral 500mg inform the doctor.
• If an allergic reaction occurs including angiodema, anaphylaxis and dermatologic reactions, the drug should be discontinue and convenient treatment must carried out. Consult with doctor for the symptoms arise.
• If symptoms of abnormal liver function, cholestatic jaundice, liver necrosis have occurs then stop the azithromycin and inform the doctor.

SIDE EFFECTS

Some serious side effects is caused by Azithral 250mg
• Watery or bloody diarrhae
• Pain in head associated with chest discomfort and severe vertigo, fainting, fast heartbeats
• Hepatic problems – upper stomach pain, decreased appetite, dark urine, clay-colored stools, jaundice
• Serious dermatological reaction – fever, pharyngtitis, blisters in face or tongue, burning of eyes, red or purple skin rashes.
Common side effects of Azithral 250mg as follows:
• Diarrhae
• Nausea, vomiting, stomach pain
• Pain in head
If these symptoms occurs call doctor immediately

MISSED DOSE

Take the missed dose immediately before next dose reaches or skip the missed dose and follows the routine schedule. Don’t make up with extra dose. Please consult with the doctor.

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