BOSUTINIB

Mechanism of action:

Bosulif 500mg(Bosutinib) is a tyrosine kinase inhibitor. Although it is able to inhibit several tyrosine kinases such as Src, Lyn, and Hck, which are members of the Src-family of kinases, its primary target is the Bcr-Abl kinase. The Bcr-Abl gene is a chimeric oncogene created from the fusion of the breakpoint-cluster (Bcr) gene and Abelson (Abl) tyrosine gene. This chromosomal abnormality results in the formation of what is commonly known as the Philadelphia chromosome or Philadelphia translocation. The Bcr-Abl gene expresses a particular kinase that promotes the progression of CML. A decrease in the growth and size of the CML tumour has been observed following administration of Bosulif (Bosutinib). Bosulif (Bosutinib) did not inhibit the T315I and V299L mutant cells.

Dosage and Administration:

Use Bosulif (Bosutinib) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Bosulif (Bosutinib). Talk to your pharmacist if you have questions about this informatio
• Take Bosulif (Bosutinib) by mouth with food.
• Swallow Bosulif 500mg whole. Do not break, crush, cut, or chew before swallowing.
• Do not eat grapefruit or drink grapefruit juice while you use Bosulif (Bosutinib).
• Check with your doctor to see if you should drink extra fluids while you are taking Bosulif (Bosutinib).
• Continue to take Bosulif (Bosutinib) even if you feel well. Do not miss any doses.
• If you miss a dose of Bosulif (Bosutinib), take it as soon as you remember. If it has been more than 12 hours since your last dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
• Ask your health care provider any questions you may have about how to use Bosulif (Bosutinib).

Side effects:

Nausea,vomiting,stomach/abdominal pain, loss of appetite, joint pain, headache, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Store:

Store at room temperature away from moisture and heat.

Precaution:

Before taking Bosulif (Bosutinib), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease.

WARNING:

Bosulif 500mg is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.