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PRODUCT DETAILS

Brand name : Campto
Strength : 100mg
Active substance : Irinotecan
Manufactured by : Pfizer’s Ltd
Pack : 5ml in a vial

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Campto 100mg is a camptothecin derivative that exerts antitumor activity against a variety of tumors.The active metabolite of Campto is SN-38 produced in the body by carboxylesterase .
Campto 100mg is used to cure cancers of the colon and rectum. It is usuallyadministering with other chemotherapy medicines in a combination chemotherapy.
Campto 100mg is a prescription drugs which is used under supervision by medical physician

INDICATION

Campto 100mg is mainly used for the treatment in patients with metastatic colon or rectal cancer.

DOSAGE

Colorectal cancer :
Monotherapy dosage :
Premediate the patients with antiemetic agents
For experience cholinergic symptoms in patient’s atropine treatment should be considered
Dose 1: 125mg/m2 IV infusion over 90 minutes on days 1,8,15,22, then 2 weeks off then repeat administrated weekly Dose 2: 350mg/sq. meter IV Infusion over 30-90 minutes q3weeks administrated once every 3 weeks.
Combination therapy :
Premediate the patients with antiemetic agents
For experience cholinergic symptoms in patient’s atropine treatment should be considered
Dose 1: 180mg/m2 IV infusion over 30-90 minutes once on days 1,15, and 29, then followed by infusion with leucovorin and 5- fluorouracil; next cycle begins on day 43
Dose 2: 125mg/sq. meter on days 1,8,15 and 22 IV Infusion over 90 minutes then followed by bolus doses of leucovorin and 5-fluorouracil

MECHANISM

Camptothecin is a derivative of irinotecan which interact particularly with the enzyme topoisomerase I, which relieves torsional strain in DNA by activating reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and inhibitsrelocation of these single-strand breaks. The cytotoxicity of Irinotecan is because of double-strand DNA injury produced during DNA combination when multiplication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot expertly repair these double strand breaks.

ADME

Campto 100mg has time to Peak Plasma Concentration of Campto 100mg is 1660 ng/mL; SN-38 26.3 ng/mL Campto 100mg has Protein Bound: 30-68%; SN-38 95% and Vd: 110-234 L/m²
Campto 100mg is mainly metabolized in hepatic, to SN-38; SN-38 is further metabolized by UGT1A1 and metabolites are metabolized to SN-38
Excretion of Campto 100mg through urine, feces
Half-Life of Campto: 6-12 hr; SN-38 10-20 hr

PRECAUTION

Drug Campto 100mg is exposed to photodegradation, specifically in neutral & alkaline solutions
When treatment will cause Hyperbilirubinemia, elderly, receiving radiation therapy, abdominal/pelvic radiation history
Not for use in concomitant with a regimen of 5-FU/LV administered for 4-5 consecutive days every 4 weeks outside of a clinical study
While on Campto treatment interstitial pulmonary disease (IPD)-like events, contains fatalities, have been resulted (in combination and as monotherapy) for treatment of colorectal cancer and other advanced solid tumors
Risk of both early and late forms of diarrhea will occurs on treatment with Campto
Risk of serious myelosuppression; manage febrile neutropenia immediately with antibiotic support; discontinue therapy and decrease subsequent doses if necessary

DRUG INTERACTION

• Wheninteraction of Campto 100mg with 5-fluorouracil and leucovorin (LV), the disposition of irinotecan was not substantially altered.
• Co administration of Campto 100mg with strong CYP34A inducers do not administer unless there are no therapeutic alternatives
• When concomitant use of Campto 100mg with strong CYP34A inhibitors may increase systemic exposure to irinotecan or SN-38

CONTRAINDICATION

Campto 100mg contraindicated in patients with known hypersensitivity to the drug or its excipients

STORAGE

Campto 100mg is Store at 20℃ to 25 ℃
Protect from light
Keep in its original vial until the time of use

SIDE EFFECTS

Common side effects of Campto 100mg :
Anxiety, Black, tarry stools, Changes in skin colour, Bruising, Chest pain, Decrease appetite, Confusion, Constricted pupils, Hoarseness, Dark urine , Hair loss, Mouth ulcers, Tummy pain.
Serious side effects of Campto 100mg :
Decreased amount of urine, Troubled breathing, Hives , Rapid weight gain, Constipation, Liver changes, Increased blood pressure, Swelling around the drip site, Skin rash, Dizziness, Blood clots.

MISSED DOSE

If dose is missed, then take the dose immediately before reach of next dose time or leave the missed dose and follow the normal schedule. Avoid have extra dose which leads to over dosage
Consult the doctor about missed dose and overdose

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