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PRODUCT DETAILS

Brand Name : Caprelsa
Composition : Vandetanib
Strength availability : 300mg
Manufactured by : Genzyme Corp
Pack : 30 film tablets
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Vandetanib is a generic form of brand name Caprelsa 300mg and is a prescription drug which is used under the guidance of medical practioners.
Caprelsa 300mg belongs to oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell multiplication with the possible for use in a broad range of tumour types.
Caprelsa 300mg was authorized by the FDA for the treatment nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.

INDICATION

Caprelsa 300mg is used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.

ADME

Peak plasma concentration is 6 hr (range 4-10 hr) and steady state is 3 months.
Bounding of plasma protein is 90% and volume of distribution is 7450L.
Caprelsa 300mg is metabolized by CYP3A4.
The drug elimination through feces 44% and via urine collection period of 21 day after single dose.

DOSAGE

The usual dose of Caprelsa is 300mg administrated orally once daily until disease progression or unacceptable toxicity occurs. Avoid crushing of tablets, disperse the tablet in 2 ounces of water by stirring 10 minutes approximately. Be careful, do not use other liquids for dispersion and swallow the medicine soon after dispersion, if any remaining residue with 4 additional ounces of water and swallow.
Th dispersion liquid can be administrated via nasogastric or gastrostomy tubes.

MECHANISM

Vandetanib belongs to targeted therapy whichaims and join to the tyrosine kinase receptors and prohibits epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), readjust during transfection (RET), protein tyrosine kinase 6 (BRK), TIE2, EPH kinase receptors and SRC kinase receptors on the surface of the cell. By binding to these receptors Vandetanib Stops an important pathway whichadvance cell division.

PRECAUTION

Effective CYP3A4 inducers reduced exposure to Caprelsa 300mg by up to 40%; however, no clinically significant effect on exposure to Caprelsa 300mg was observed in the presence of the potent CYP3A4 inhibitors.
Fatal skin reactions, containing Stevens-Johnson syndrome and severe toxic epidermal necrolysis reported; systemic treatment such as corticosteroids may be needed; permanently stop therapy for severe skin reactions.
Interstitial lung disease (ILD), causes in death has been resulted; inhibitCaprelsa 100mg and examine unexplained Dyspnea, cough, and fever; applicable measures should be taken for ILD.
Ischemic cerebrovascular events, haemorrhage, heart failure, diarrhea, hypothyroidism, hypertension, and reversible posterior leukoencephalopathy syndrome, have been observed.
Can cause fetal harm when administered to pregnant women; Do not get pregnancy while gettingCaprelsa 100mg and for 4 months following treatment.

DRUG INTERACTION


While interaction with a strong CYP3A4 inducer will decreased Vandetanib plasma concentration. Hence avoid concomitant use of known strong CYP3A4 inducers during Caprelsa 300mg treatment.
When administrating Caprelsa 300mg with drugs that are transported by OCT2 will increased plasma concentration of metformin.
When administering Caprelsa 300mg with digoxin will increased plasma concentration of digoxin.
Avoid concomitant of Caprelsa 300mg with agents which may prolong the QT interval.

CONTRAINDICATION

Caprelsa 300mg avoid use in patients with congenital long QT syndrome.

MISSED DOSE

If dose is missed, then take the dose as soon as possible before reach of next dose time or skip the missed dose and follow the normal schedule. Do not have extra dose which leads to over dosage. Avoid taking missed dose within 12 hours of the next dose.
Consult the doctor about missed dose and overdose.

STORAGE

Caprelsa 300mg tablets should be stored at 25℃.

SIDE EFFECTS

Headache, Fatigue, Low blood sugar, Abdominal pain, Poor appetite, Low white blood cell count, Kidney problems, Dry skin, Vomiting, Weakness, Irregular heart beat, Difficulty sleeping, Sensitivity to sunlight, Bleeding, Anemia, Bilirubin, Itching, Heartburn, Cough, Upper respiratory infection, Depression, Weight loss, Diarrhea, Rash, Elevated Liver Enzymes (ALT), Low calcium levels, Acne, High blood pressure, Nausea.

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