Azapure 50mg - Description , Uses , Prices , Side effects.

Azapure 50mg (Azathioprine)

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composition: Azathioprine

Brand nameAzapureActive substanceAzathioprineStrength50mgCategoryNephrologyManufacturerIntas Pharma

Description of Azapure 50mg (Azathioprine 50mg)

Azapure 50mg (Azathioprine 50mg) tablet belongs to immunosuppressant medication, that means it decrease the body's defense system or immune response
Azapure 50mg (Azathioprine 50mg) is an inactive form which is metabolized to its active component 6-mercaptopurine (6-MP), a purine antagonist which prvents DNA synthesis and lymphocyte proliferation.
Azapure 50mg (Azathioprine 50mg) is a prescription drug provided under the supervision of medical practioners.

INDICATIONS of Azapure 50mg (Azathioprine 50mg)

Azapure 50mg (Azathioprine 50mg) is a drug used for the treatment of addition for the prevention of rejection in kidney homotransplantations.
Azapure 50mg (Azathioprine 50mg) is a drug used for the treatmentfor the management of active rheumatoid arthritis to reduces signs and symptoms.

MECHANISM OF Azapure 50mg (Azathioprine 50mg)

Azathioprine consist of purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a inactive formwhich is altered by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine.
Then 6-MP is metabolized by hypoxanthine-guanine phosphoribosyl transferase into 6-thioguanosine-5'-phosphate and 6-thioinosine monophosphateboth prohibit nucleotide conversions and de novo purine development. This causes toprevention of DNA, RNA, and protein combination.
As a result, cell multiplication may be blocked, specifically in lymphocytes and leukocytes.

ADME of Azapure 50mg (Azathioprine 50mg)

Well absorbed, and maximum plasma radioactivity is 1-2 hours.
plasm protein binding is 30%.
Mostly azathioprine alters to the main metabolites 6-mercaptopurine and 6-thioinosinic acid via a non-enzymatic process and glutathione transferases. Stimulating of 6-mercaptopurine happen via hypoxanthine-guanine phosphoribosyl transferase (HGPRT) and a set of multi-enzymatic processes included kinases to form 6-thioguanine nucleotides (6-TGNs) as important metabolites.
Fastly eliminated from blood and in urine after 8 hours has no azathioprine or mercaptopurine is detectable.

SIDE EFFECTS of Azapure 50mg (Azathioprine 50mg)

Serious side effects :
Lymphoma
Fever
Hepatotoxicity
Macrocytic Anemia
Myalgia
Nausea or vomiting
Rash
Skin cancer
Steatorrhea
Abdominal pain
Alopecia
Arthralgia
Bacterial, fungal, protozoal, viral infections
Bone marrow suppression
Diarrhoea
Sweet syndrome (acute febrile neutrophilic dermatosis)
Thrombocytopenia
Leukopenia (28-50%)
Infection (20%)

PRECAUTIONS of Azapure 50mg (Azathioprine 50mg)

While on treatment with Azapure 50mg (Azathioprine 50mg)tablet Long-term use increases risk of neoplasia
• While on treatment with Azapure 50mg (Azathioprine 50mg)will Increased risk of infection and hepatotoxicity; checkhepatic function periodically; hepatic sinusoidal obstruction syndrome resulted; stop the therapy if suspected
• When using Azapure 50mg (Azathioprine 50mg) tablet is a Chronic immunosuppression with this purine antimetabolite raises neoplasia risk, mutagenic risk, and hematologic toxicities
• Using of drug Azapure 50mg (Azathioprine 50mg)tablet, resulted with malignancies contain posttransplant lymphoma and hepatosplenic T-cell lymphoma (HSTCL) in patients with inflammatory bowel disease

DRUG INTERACTION of Azapure 50mg (Azathioprine 50mg)

Co administration with captopril will show pharmacodynamic synergism and use with caution and will have risk of neutropenia.
Azapure 50mg (Azathioprine 50mg) co administration with zidovudine will either raise the toxicity of the other by pharmacodynamic synergism and will have risk of myelosuppression. Use with caution.
Azapure 50mg (Azathioprine 50mg) co administration with adalimumab will have high immunosuppressive effects and risk of infections occurs. Avoid usage both combinations.
Azapure 50mg (Azathioprine 50mg) co administration with allopurinol will have high levels of azathioprine by reducing metabolism and increased risk of bone marrow toxicity.
Azapure 50mg (Azathioprine 50mg) co administration with cyclosporine both increase immunosuppressive effects. Avoid the using with Azathioprine

CONTRAINDICATION of Azapure 50mg (Azathioprine 50mg)

Hypersensitivity
• Pregnancy while treatment for rheumatoid arthritis

PREGNANCY OF Azapure 50mg (Azathioprine 50mg)

Pregnancy category is D
Avoid Azapure 50mg (Azathioprine 50mg) treatment during pregnancy because it will cause fetal harm

LACTATION OF Azapure 50mg (Azathioprine 50mg)

Some of evidence reveal the breastfeeding during Azapure 50mg (Azathioprine 50mg) treatment is safe but proper discussion with doctor before using Azapure 50mg (Azathioprine 50mg) tablet

DOSAGE OF Azapure 50mg (Azathioprine 50mg)

For oral dosage form – for kidney transplant rejection :
In adults the prescribed dose is based on body weight and should be driven by doctor
Commonly starting dose is 3 to 5 mg/kg/day initially on day of transplant given as a single dose on once a day. The first dose is initiate either 1 to 3 days before the transplant or on the day of the transplant. The doctor may adjust your dose as needed.
Usage of the drug in children and dose should be discussed by doctor.
For rheumatoid arthritis :
In adults the dose is depends on body weight and should be driven by doctor.
Normally starting dose is 1 mg/kg/day IV/PO initially on day of transplant of body weight per day administer as a single dose once a day or split into two doses. Inform the doctor may adjust your dose as necessary. Still the dose is generally not ≥2.5 mg/ kg of body weight per day.
In children the drug usage and dose should be discussed by doctor.
Overdose :
If overdose occurs, then please seek emergency department. Avoid the overdose, have the drug properly

STORAGE of Azapure 50mg (Azathioprine 50mg)