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PRODUCT DETAILS

Brand Name : Cresp
Composition : Darbepoetin alfa
Strength availability : 200mcg
Manufactured by : Dr. Reddy’s Laboratories Ltd
Packing : 0.4ml in a prefilled syringe
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Cresp 200mcg is a man-made form of a protein which promote your body form red blood cells.
This protein may be decreased when you have kidney failure or use certain regimens. When lesser red blood cells are formed, which develop a condition called Anemia.
Darbepoetin alfa is necessary to cure Anemia occurred by chemotherapy or chronic kidney disease.


INDICATION

Cresp 200mcg is prescribed for the treatment in patients with Anemia associated with chronic kidney disease (CKD).
Cresp 200mcg is prescribed for the therapy in patients with Anemia is caused by chemotherapy cancer treatment but it is a support medication, it will not treat cancer
Cresp 200mcg is prescribed for the therapy in patients with Symptomatic Anemia along with myelodysplastic syndromes (MDS).

DOSAGE

The usual dose of this drug will be changed for different patients.
Anemia from chronic kidney failure :
The dose considered for adults and children – dose chiefly based on body weight
Initial treatment: The prescribed dose is 0.45 to 0.75 mcg/kg of body weight injected through IV or SC (under the skin) once a week or once every week.
Your doctor may adjust the dose as required
Anemia from cancer chemotherapy :
For adult: dose is based on body weight
Initial treatment: The usual dose is 2.25mcg once every 3 weeks injected under the skin.
The dose for children and use should be determined by your doctor

MECHANISM

Darbepoetin alfa activate erythropoiesis by exciting the division and differentiation of committed erythroid progenitor cells; produce the release of reticulocytes from the bone marrow into the bloodstream, where they mature to erythrocytes. There is a dose-reaction relationship with this effect. This results in a raise in reticulocyte counts pursue by a increase in haematocrit and hemoglobin levels.

ADME

Absorption: slow
Time to maximum plasma concentration: 34 hr subcutaneously (SC)
Bioavailability for adult: 37% SC and
Bioavailability for children: 54% SC
Volume of distribution: 0.06L/kg
Half-life is 46 hr (SC) and
if IV then 21 hr.

PRECAUTION

• While Reduction of dose if Hgb has high exceeds 1 g/dL in any 2-week period
• Increased the mortality and/or higher the risk of tumor progression or relapsed in patients with cancer
• When treatment with Cresp 200mcg has high risk for seizures in patients with CKD; high checking of these patients for alter in seizure frequency or premonitory symptoms
• If serious Anemia and low reticulocyte count occurs during treatment, withhold treatment and check out for pure red cell aplasia.
• When treatment with Cresp 200mcg injection will causes high mortality, myocardial infarction, stroke, and thromboembolism: Using ESAs to target a haemoglobin level of greater than 11 g/dL raises the risk of severe adverse cardiovascular reactions
• When treatment with Cresp 200mcg injection will leads to known porphyria, sickle cell Anemia, thalassemia in patients

DRUG INTERACTION

No drug interaction involved in the drug Cresp 200mcg Injection

CONTRAINDICATION

The patients contraindicated with Cresp 200mcg injection causes
Severe hypertension
After treatment results in pure red cell aplasia
Allergic problem

MISSED DOSE

If dose is forget to take then have it soon before next dose reaches or leavethe misseddose and follow normal timing
Please Consult with the doctor

STORAGE

Store at 2℃ – 8℃ (36℉ to 46℉)
Do not freeze
Protect from light and protect from light

SIDE EFFECTS

Cresp 200mcg as some of the side effects as follows;
Hypertension
Seizures
Serious allergic reaction: wheezing, dizziness, skin rash, itching
Shortness of breath
Cough
Low blood pressure during dialysis
Pain in abdominal
Edema of the arms or legs

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