applepharmaceutical@gmail.com
drug

PRODUCT DETAILS

Generic : Tamoxifen
Trade name : Cytotam
Strength : 10mg
Manufactured by : Cipla Ltd
Packing : Pack of 30 tablets

for MORE INFORMATION !!!

Cytotam 10mg is belongs to the anticancer agents and covered by film coated tablet, the drug also a nonsteroidal antiestrogen and work as a modulator with tissue selective activities for the treatment.
Cytotam 10mg as a stimulating agent (estrogen) in metabolism of cholesterol, bone density, and cell replication in the endometrium.
Cytotam 10mg will help for inhibition of estrogen receptor positive cancer.

INDICATION

Cytotam 10mg is used to treat of early breast cancer in women whose been already treated with surgery, radiation, and chemotherapy.
Cytotam 10mg will help to reduce the risk of developing a more serious type of breast cancer in women who had breast cancer that will not spread outer part of the milk duct where it forms (ductal carcinoma).

DOSAGE

Regular adult dose for :
20 to 40mg for 5 years daily administer orally for breast cancer doses is > 20mg given by dividing dose (morning and evening) 20mg 5 years daily given orally for DCIS followed by surgery and radiation on breast
For 5 years administer 20mg daily taken orally to decrease the action of breast cancer in women at increased risk for breast cancer 20mg OD orally or 10mg twice daily orally given for adult dose for adjuvant breast cancer and Duration: 5 years
Pediatric dose for :
girls 2 to 10 years :
20mg once daily via oral route; duration up to 12 months administrated for McCune- Albright syndrome
20mg once daily via oral route; duration up to 12 months given for Precocious Puberty

MECHANISM OF ACTION

Cytotam is a type of nonsteroidal agent which interlinked to estrogen receptors (ER), provoke a conformational change in the receptor. This results in a inhibits in the verbalization of estrogen based on genes.
Combine of Cytotam is extended to the nuclear chromatin of these consequence will reduced DNA polymerase action, repair thymidine discharge and restriction uptake of estradiol, hence lowers estrogen response.
Cytotam enough that to concomitant with other co activators or co repressors in the tissue and fuse with different estrogen receptors,

PHARMACOKINETICS

Absorption :
The time to high plasma concentration is 40mg/ml and Tmax is 5 hours after dosing.
Distribution:
not available
Metabolism:
In hepatic Cytotam is metabolized.
Elimination:
Route of excretion is 30% via fecal and 65% was excreted from the body
Half-life is 5 to 7 days

PRECAUTION

• Consult with the doctor or pharmacist as if you have allergic condition against Cytotam or any of the compound in Tamoxifen tablets.
• Consult with the doctor that you have or have ever had renal, hepatic, or cardiac problem
• Consult with the doctor that are you pregnant or plan to become pregnant. Do not have plan for children while on treatment with Cytotam. You must use a specific method of conceiving to prevent pregnancy in yourself or your partner during your treatment with Cytotam the drug will harm the fetus.
• Avoid breast feeding while on treatment with Cytotam
• Use drug with caution due to early breast cancer signs hence during treatment with tamoxifen aware about development of breast cancer.
• Some important precautions should take care
• Effects in Metastatic breast cancer Patients
• Some breast cancer patients may report from hypercalcemia by starting few weeks treatment, if the condition occur and became severe then tamoxifen should discontinue.
• Effects on the Uterus-Endometrial Cancer and Uterine Sarcoma
• An incidence may increase with uterine malignancies and endometrial carcinoma is resulted with tamoxifen treatment.
• Non-malignant Effects on the uterus
• Due to estrogen properties of tamoxifen, an increased incidence of endometrial changes occurs involves like hyperplasia and polyps has been resulted. Hence the drug causes menstrual irregularity or amenorrhea.

DRUG INTERACTION

While interaction of Cytotam 10mg with coumarin type anticoagulants combination will leads to increase in anticoagulant effects may occur.
Concomitant use of Bromocriptine with Cytotam 10mg will increase the serum level of Cytotam and N-desmethyl tamoxifen.

CONTRAINDICATION

Cytotam 10mg is contraindicated in patients with as follows:
• Known hypersensitivity to the drug or its any ingredients
• Women concomitant use with coumarin- type anticoagulant treatment
• In women with deep vein thrombosis or pulmonary embolus history.

STORAGE

Keep away from children
Do not freeze
Keep the drug in a closed container at room temperature.

MISSED DOSE

Have the missed dose immediately before next dose duration
Next dose time arrived then left off the missed dose and follows regular schedule.
Avoid taking extra dose at same time.
Please consult the doctor for further details

SIDE EFFECTS

COMMON SIDE EFFECT:
• High tumor pain
• Tumor site forming reddening
• Hair thinning
• Weight loss
• Stomach pains
• Sexual ability lost
• Hot flashes
• Vertigo . Serious side effects may be as follows, immediately inform the doctor:
• Thirst
• muscle weakness
• restlessness
• loss of appetite
• Vision difficulty
• Fever
• Blisters
• Abscess on the, throat, face, lips, eyes, tongue, ankles or lower legs.

We'd Like to Hear From You!

PRESCRIPTION POLICY

1. myapplepharma.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. myapplepharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the myapplepharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. myapplepharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from myapplepharma.com.
6. At myapplepharma.com, a Caregiver can order prescription medicines on your behalf.


This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.