Brand name : Daunoside
Strength : 20mg
Active substance : Daunorubicin
Manufactured by : Chandra bhagat pharma Ltd
Pack : 1ml injection in a vial


Daunoside belongs to the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus.
It is containing as a sterile reddish lyophilized powder in vials for intravenous administration only Daunoside is a prescription drug provided under the guidance of medical oncologist


Daunoside is indicated for the treatment in patients with Myelogenous leukemia
Daunoside is indicated for the treatment in patients with Lymphoblastic Leukemia
Daunoside is indicated for the treatment in patients with Promyelocytic leukemia


The Acute Nonlymphocytic Leukemia recommended dose in combination with cytarabine 100mg/m2/day IV for 7 days first course, for 5 days consequent course.
Then, if patient is <60 years old: 45mg/m2 IVP days1,2,3 first course; days 1,2 consequent course.
if patient is >60 years old: 30mg/m2 IVP days1,2,3 first course; days 1,2 consequent course.
Monitor the patients cardiac, renal, hepatic function
The Acute Lymphocytic Leukemia recommended dose is 45mg/m2 IVP days 1,2,3
Monitor the patients cardiac, renal, hepatic function


Daunorubicin consist of antimitotic and cytotoxic activity through several proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the relegation portion of the ligation-relegation reaction that topoisomerase II catalyses.


The drug Daunoside has protein bound about 50-60% and volume of distribution is 20-39.2L/kg
Daunoside is metabolized in hepatic and the metabolites is Daunorubicinol
The drug excreted via feces 40% and urine 25%
Half-life is 14-20 hr for parent drug, 24-48 for Daunorubicinol


When combination with eliglustat will leads increase levels of Daunoside by P- glycoprotein efflux transporter. Avoid the drug
When Daunoside combination with tofacitinib will either raises toxicity of the other by immunosuppressive effects.
The effects of adenovirus types 4 and 7 live reduces by using Daunoside and pharmacodynamic antagonism. Avoid usage of drug




If the patients forgot to take a dose, then have the dose as soon as you remember before next dose timing or else skip the missed dose and follow normal schedule.
Consult the doctor


• When using the drug Daunoside the risk of serious cardiotoxicity (involving CHF) & myelosuppression
• The Daunoside should use with Caution in hepatic/renal impairment patients
• The drug causes cardiotoxic effects in children may be more sensitive than adults
• Avoid pregnancy
• Secondary leukaemia’s resulted when used in concomitant use with radiation or chemotherapy


• Store the unopened vials at 2℃ to 8℃.
• Store the prepared solution at 20℃ to 25℃.
• Retain in carton until time of use
• Protect the drug from light and moisture


Common side effects of Daunoside:
Pain in medication was given site
Urine may appear red-brown or orange
Reduced blood counts
Nausea or vomiting
Mouth sores
Loss of hair on the scalp.
Less common side effect of Daunoside:
Problems with fertility
Radiation recall
Discoloration of nails beds

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