applepharmaceutical@gmail.com
Duovir-300mg-&-150mg

PRODUCT DETAILS

Trade name : Duovir
Active ingredient : Lamivudine & Zidovudine
Strength availability : 150 mg and 300 mg
Manufactured by : Cipla
Package : 60 tablets

for MORE INFORMATION !!!

Duovir is a type of antiretroviral drugs which analog to nucleoside polymerase. Duovir is a combination drugs of lamivudine 150mg and Zidovudine 300mg. The drug which prevent human immunodeficiency virus (HIV) from multiplying in your body.

INDICATION

Duovir is used for the treatment of HIV-1 infection by combination with other antiretroviral drugs. Duovir is a nucleoside analogue with combination of Lamivudine and zidovudine.

DOSAGE

Duovir dosage in adults is lamivudine 150mg and zidovudine 300mg with weight of >30kg one tablet twice in a day Childern of 14-21 kg one half tablet bid and for 22-30kg one half tablet in the morning or one half tab tid. Duovir may be taken with or without food.

PHARMACOLOGY

Duovir consist of Lamivudine and Zidovudine which is a synthetic nucleoside analogue. Both drugs acts like inside cell Lamivudine and Zidovudine is phosphorylated to its active 5-triphosphate metabolite and forms Zidovudine triphosphate and Lamivudine triphosphate (L-TP). The basic action of L-TP and ZDV-TP is inhibition of reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside correlated.Both L-TP and ZDV-TP is a weak inhibitor of mammalian DNA polymerases a and b, and mitochondrial DNA polymerase g which has been reported to be incorporated into DNA of cells in culture.

PHARMACOKINETICS

Absorption : rapidly absorbed from the GI tract. Absorption with food is delayed Bioavailability: 80-87% (Lamivudine); approx 60-70% (zidovudine). Time to peak plasma concentration: Approx 1 hr.
Distribution : Passes through blood-brain barrier and placenta that enters breast milk and Detected in semen (zidovudine). Volume of distribution: 1.3 L/kg (Lamivudine); 1-2.2 L/kg (zidovudine). Plasma protein binding: Up to 36% (Lamivudine); 34-38% (zidovudine).
Metabolism : Both regimens are metabolized inside the cells to form the active triphosphate. Zidovudine goes through hepatic metabolism, mainly to the inactive glucuronide.
Excretion : Lamivudine and zidovudine excreted Via urine, (mainly as unchanged drug) Elimination half-life: 5-7 hr (Lamivudine); 0.5-3 hr (zidovudine).

DRUG INTERACTION

Duovir given with Emtricitabine may develop cross –resistance. Continue use of zidovudine with Ribavirin leads to Excerabtion of anemia. Lamivudine and zalcitabine may prevent intracellularily phosphorylation of one another. Interaction of zidovudine with stavudine and doxorubicin will produce antagonistic effects. Duovir used with interferon alfa in HIV may develop risk of hepatic decompenstion.

CONTAINDICATION

Previously demonstrating clinically significant in patients are hypersensitivity to any of the component of Duovir. The patient with low body weight should not be receive Duovir dose.

WARNING

Monitoring Parameters , Monitor haematological parameters observe for appearance of hardened infections and signs and symptoms of pancreatitis. Periodically check liver function test and for several month following discontinuation of therapy for patients co-infected with hepatitis B virus and HIV. Obese women with hepatomegaly, hepatitis or other risk factors causes liver disease and hepatic steatosis; hepatitis B or C virus co-infection leads risk factors for pancreatitis Patient with poor bone marrow reserve before the treatment. Renal and severe hepatic impairment. Children Pregnancy.

MISSED DOSE

If dose is missed, patients should consult with medical practitioner & follow their instructions. Continue the regular dosing schedule .Avoid the missed dose if possible. Do not self medicate the drug.

SIDE EFFECTS

If dose is missed, patients should consult with medical practitioner & follow their instructions. Continue the regular dosing schedule .Avoid the missed dose if possible. Do not self medicate the drug.
More common:
Chills, fever, pale skin, sore throat weakness, head pain Less common: stomach ache, nausea, skin rash, vomiting, yellow eyes, coughing, l oss of appetite, sleeping trouble.
Incident not known :
blurred vision, dry mouth, hair loss, increased (hunger,thirst,urination), chest discomfort, wheezing, myalgia, convulsions.

We'd Like to Hear From You!

PRESCRIPTION POLICY

1. myapplepharma.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. myapplepharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the myapplepharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. myapplepharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from myapplepharma.com.
6. At myapplepharma.com, a Caregiver can order prescription medicines on your behalf.


This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.