Alectinib 150mg (Alectinib)

Description of Alecensa 150mg (Alectinib 150mg)

Alecensa 150mg (Alectinib 150mg) belongs to class of second generation oral medicine which specificallyprevents the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.

Alecensa is a prescription medicine which used under the guidance of doctor.

It is part used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells.

Medical use /Indication of Alecensa 150mg (Alectinib 150mg)

Alecensa 150mg (Alectinib 150mg) is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).

Mechanism of Action Alecensa 150mg (Alectinib 150mg)

Particularly, crizotinib prevents anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, Alectinib is a type of tyrosine kinase inhibitor which target ALK and RET. In nonclinical studies, Alectinib inhibits ALK phosphorylation and ALK-mediated activation of the downstream indicating proteins STAT3 and AKT anddecreases tumor cell viability in multiple cell lines harbouring ALK fusions, elaborations, or activating mutations.

ADME of Alecensa 150mg (Alectinib 150mg)

Peak plasma concentration 4 hours and bioavailability of Alecensa 37%
Alectinib bound to human plasma proteins 99%
Metabolized by CYP3A4 to its major active metabolite M4, the main circulating moieties in plasma, total radioactivity 76% constituting.
In oral administration, radioactivity 98% was excreted in feces. 84% dose was excreted in the feces unchanged Alectinib.
Half-life is 33 hours

Side effects of Alecensa 150mg (Alectinib 150mg)

Alecensa 150mg (Alectinib 150mg)  causes some side effects while administrating certain condition as follows :

COMMON SIDE EFFECTS

Muscle pain, Bradycardia, Tiredness, Constipation, Anemia , Hepatotoxicity, Feeling tired, Feeling less hungry than usual, Dark urine, Itchy skin, Nausea or vomiting, Abdominal Pain on the right side , Bleeding or bruising more easily than normal, Lung Problems, Trouble breathing, Shortness of breath , Cough, Fever .

Precautions of Alecensa 150mg (Alectinib 150mg)

Embryo-fetal toxicity:

Depends on data from animal studies and its pharmacological action, Alecensa 150mg (Alectinib 150mg)  can cause fetal harm when administered to pregnant women.

While Alecensa 150mg (Alectinib 150mg)  administration, Symptomatic bradycardia may have observed; control heart rate and blood pressure regularly
Alecensa 150mg (Alectinib 150mg)  may causes Severe myalgia and elevated CPK resulted; advise patients to report any unexplained muscle pain, tenderness, or weakness;

Renal impairment occurred during Alecensa 150mg (Alectinib 150mg)  treatment; incidence of Grade ≥3 renal impairment was 1.7%, of which 0.5% were fatal events.

Drug interaction of Alecensa 150mg (Alectinib 150mg)

No pharmacokinetic interactions with Alecensa 150mg (Alectinib 150mg) needed dosage adjustment have been observed.

Pregnancy of Alecensa 150mg (Alectinib 150mg)

Based on studies of animal and mechanism of action, Alecensa 150mg (Alectinib 150mg) will cause fetal harm when given to pregnant women. Advice the female not to become pregnant while on treatment with Alecensa 150mg (Alectinib 150mg) 

Lactation of Alecensa 150mg (Alectinib 150mg)

During treatment with Alecensa 150mg (Alectinib 150mg) , advise the women not to breastfed to infants

Dosage of Alecensa 150mg (Alectinib 150mg)

Non- Small Cell Lung Cancer

The usual dose is 600mg PO BID until disease progression or unacceptable

Renal impairment patients dose is 450mg orally twice daily

Alecensa 150mg (Alectinib 150mg)  is administrated with food.

Storage of Alecensa 150mg (Alectinib 150mg)

Store at below 30℃

Store the medicine in original container

Missed dose of Alecensa 150mg (Alectinib 150mg)

If the patient vomits after taking a dose of ALECENSA or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.