Celofos 2000mg (Ifosfamide)

Ifosfamide
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Brand nameCelofosInternational trade nameIfexActive substanceIfosfamideStrength2000mgCategoryAnti Cancer

Description of Celofos 2gm (Ifosfamide 2gm)

Ifosfamide is generic form of brand name Celofos 2gm (Ifosfamide 2gm)Celofos 2gm (Ifosfamide 2gm) is an antineoplastic agent chemically associated to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. Celofos 2gm (Ifosfamide 2gm) is a prescription medicine which is used under the supervision of medical oncologist

Medical use /Indication of Celofos 2gm (Ifosfamide 2gm)

  • Celofos 2gm (Ifosfamide 2gm)is used for the treatment in patientswith relapsed testicular cancer and germ cell tumors
  • Celofos 2gm (Ifosfamide 2gm) is used for the treatment in patients with Sarcomas (soft-tissue, osteogenic sarcoma, Ewing's sarcoma)
  • Celofos 2gm (Ifosfamide 2gm) is used for the treatment in patients with Non-Hodgkin's lymphoma
  • Celofos 2gm (Ifosfamide 2gm) is used for the treatment in patients with Hodgkin's disease
  • Celofos 2gm (Ifosfamide 2gm) is used for the treatment in patients with Non-small cell and small cell lung cancer
  • Celofos 2gm (Ifosfamide 2gm) is used for the treatment in patients with Bladder cancer
  • Celofos 2gm (Ifosfamide 2gm) is used for the treatment in patients with Head and neck cancer
  • Celofos 2gm (Ifosfamide 2gm) is used for the treatment in patients with Cervix cancer

Mechanism of Action Celofos 2gm (Ifosfamide 2gm)

The proper mechanism of Ifosfamide has not been described but occur to be like other alkylating agents. Ifosfamide mechanism by sticking the cancer cell’s DNA (the cell’s genetic code) composed so which it can't come apart again. This means which the cell will not multiply and grow.

ADME of Celofos 2gm (Ifosfamide 2gm)

Time to high plasma of Celofos 2gm (Ifosfamide 2gm) is 20-30 minutes and the bioavailability are 90-100%

Volume of distribution is 33L

Celofos 2gm (Ifosfamide 2gm) is extensively metabolized and has metabolites of 3-dechloroethylifosfamide, 2- dechloroethylifosfamide and carboxyifosfamide

Celofos 2gm (Ifosfamide 2gm) is eliminated at high dose of 5000mg/m2 in urine 70-86% and at low dose 1600-2400 about 12-16%.

Half- life for high dose of 3800-5000mg/m2 is 15hr and 7hr for low dose of 1800-2400 mg/m2

Side effects of Celofos 2gm (Ifosfamide 2gm)

  • Alopecia
  • Malaise
  • Dysphagia
  • Low WBC count
  • Low platelet count
  • Loss of hair
  • Menopause
  • Fertility loss
  • Vomiting and nausea
  • Hypotension
  • Central neurotoxicity

Precautions of Celofos 2gm (Ifosfamide 2gm)

  • With Celofos 2gm (Ifosfamide 2gm)causes Haemorrhagic cystitis reported
  • Stop treatment if it occurs Confusion and coma due to CNS toxicity have been associated with therapy.
  • While treatment with Celofos 2gm (Ifosfamide 2gm)may occur Bone marrow suppression
  • Dose-related serious myelosuppression occurred

Drug interaction of Celofos 2gm (Ifosfamide 2gm)

When Celofos 2gm (Ifosfamide 2gm) interaction with CYP3A4 inducers may increase the metabolism of Ifosfamide to its active alkylating metabolites When Celofos 2gm (Ifosfamide 2gm) interaction with CYP3A4 inhibitors may decrease the metabolism of Ifosfamide to its active alkylating metabolites perhaps reducing the effectiveness of Ifosfamide treatment

Contraindication of Celofos 2gm (Ifosfamide 2gm)

Celofos 2gm (Ifosfamide 2gm) is contraindicated in patients with Known hypersensitivity
Celofos 2gm (Ifosfamide 2gm) is contraindicated in patients with Urinary outflow obstruction

Pregnancy of Celofos 2gm (Ifosfamide 2gm)

Celofos 2gm (Ifosfamide 2gm) will have pregnancy category D

Advice the pregnant women about potential hazard to the fetus and using during pregnancy time is contraindicated

Lactation of Celofos 2gm (Ifosfamide 2gm)

Avoid breastfeed during the treatment with Celofos 2gm (Ifosfamide 2gm) because potential hazard to the fetus may occur.

Dosage of Celofos 2gm (Ifosfamide 2gm)

  • Usual adult dose for testicular cancer is 1.2 g/m2, diluted to 50mg/mL IV over 30 minutes once a day with mesna administrated via IV, Oral, or continuous IV infusion given just before and 4 and 8 hours after each dose and aggressive hydration 2 to 4 L/day.
  • Celofos 2gm (Ifosfamide 2gm) is commonly administrated for 5days.

Repeated every 3 to 4 weeks :

  • The usual dosefor cervical cancer in combination with other cancer medicines as a part of the BIP regimen is 5000mg/m2 over 24 hours on day 2

Cycle repeated every 21 days :

  • The usual dose for cervical cancer in combination with other cancer medicines as a part of the BIC regimen is 2000 mg/m2IV on day 1 through 3

Cycle repeated every 21 days :

  • Paediatric dose for Malignant disease: The recommended dose is 1200 to 1800mg/m2IV for 3 to 5 days every 21 to 28 daysOr administrated has 5000mg/m2 over 24 hours infusion or 3g/m2/ day for 2 days

Storage of Celofos 2gm (Ifosfamide 2gm)

Store the Celofos 2gm (Ifosfamide 2gm) 2 ℃ to 8 ℃

Missed dose of Celofos 2gm (Ifosfamide 2gm)

If the patient fails to take a dose of medicine or missed to take a dose, then should not take an extra dose, but to take the next dose at the regular time, leave the missed dose.

Brand name:
Celofos
International trade name:
Ifex
Active substance:
Ifosfamide
Strength:
2000mg
Category:
Anti Cancer
Manufacturer:
Celon Labs
Packaging:
1 Vial
Product form:
Injection

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