Valcivir 500mg (Valacyclovir)

Valacyclovir
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Cipla Ltd

Valcivir 500mg (Valacyclovir)

ManufacturerCipla LtdBrand nameValcivirActive substanceValacyclovir Strength500mgCategoryAnti ViralManufacturerCipla Ltd

Description of Valcivir 500mg (Valacyclovir 500mg)

Valcivir 500mg (Valacyclovir 500mg) involves an active composition like valacyclovir that are pharmacologically classified as nucleoside analogue of viral DNA polymerase prohibitor. Valacyclovir belongs to synthetically classified as nucleoside analogue. Valacyclovir is normaly present as promedicine which gets changed into an active molecule known as acyclovir.

Medical use /Indication of Valcivir 500mg (Valacyclovir 500mg)

The main indication of valacyclovir is needed in the condition like; Herpes simplex & herpes zoster In adults; Valcivir 500mg (Valacyclovir 500mg) is mostly required for the treatment of cold sores by Herpes Labialis. 

Valcivir 500mg (Valacyclovir 500mg) capability started after the advancement of clinical signs of cold sore has not been investigated. 

Valcivir 500mg (Valacyclovir 500mg) is additionally exhibit in the condition like starting scene of genital herpes in immuno able grown-ups. 

Valcivir 500mg (Valacyclovir 500mg) is also indicated in the treatment of relapsed episodes of genital herpes in immuno competent episodes. 

Valcivir 500mg (Valacyclovir 500mg) is determined for cutting edge holding black treatment of repetitive scenes of genital herpes in immuno skillful and HIV-1 contaminated grown-ups. 

Valcivir 500mg (Valacyclovir 500mg) is also indicated for the decline of transportation of genital herpes in immuno competent adults. 

Valcivir 500mg (Valacyclovir 500mg) is used in the treatment of herpes zoster in immuno competent adults. In pediatrics; In pediatric patients, Valcivir 500mg (Valacyclovir 500mg) is contain in the therapy of cold sores with the age of greater or equal to 12 years. 

Valcivir 500mg (Valacyclovir 500mg) is also used for the therapy of chicken pox in immuno competent pediatric patients with age of 2 to less than 18 years.

Mechanism of Action Valcivir 500mg (Valacyclovir 500mg)

Valacyclovir is a promedicine which is go through phosphorylation by using viral thymidine kinase enzyme for convert of acyclovir triphosphate, an active metabolite. This active molecule is included in the prohibition of herpes viral DNA replication by aggressive prohibition of viral DNA polymerase. After infusion of this metabolite into the virus & leads to terminate the developing viral DNA chain.

Valacyclovir consist of; Block the DNA synthesis Destabilizing the strand Prevention of new viral growth

ADME of Valcivir 500mg (Valacyclovir 500mg)

Absorption of Valcivir 500mg (Valacyclovir 500mg)

After Valcivir 500mg (Valacyclovir 500mg) oral intake , valacyclovir is fastly absorbed from the gastrointestinal tract and exhibit oral bioavailability by 54.5% plus or minus 9.1%.

Distribution of Valcivir 500mg (Valacyclovir 500mg)

The Valcivir 500mg (Valacyclovir 500mg) has human plasma protein binding capacity is 13 to 18%.

Metabolism of Valcivir 500mg (Valacyclovir 500mg)

Valacyclovir is hastily absorbed and approximately 99% of medicine get convinced into an active form like acyclovir & L-valine by sustain first pass metabolism & hepatic metabolism by enzymatic hydrolysis.

Elimination of Valcivir 500mg (Valacyclovir 500mg)

Radioactivity gets eliminated via urine is nearly 89%. The mean half life period of valacyclovir is 2.5 to 3.3 hours.

Side effects of Valcivir 500mg (Valacyclovir 500mg)

The common side effects :

  • Anemia
  • Increased AST
  • Neutropenia
  • Respiratory tract infection
  • Decreased platelet counts
  • Nasopharyngitis
  • Headache
  • Dizziness
  • Nausea
  • Abdominal pain

The major adverse effects of Valcivir 500mg (Valacyclovir 500mg) are :

  • Thrombotic thrombocytopenia purpura/hemolytic uremic syndrome
  • Acute renal failure
  • Central nervous effects

Precautions of Valcivir 500mg (Valacyclovir 500mg)

Central nervous system effects :

In pediatric patients with or without renal impairment should be describe with nervous problems like agitation, hallucination, confusion, seizures while on treatment with Valcivir 500mg (Valacyclovir 500mg). In this condition treatment should be stopped.

Thrombocytopenia :

This circumstances occurs during the treatment using with Valcivir 500mg (Valacyclovir 500mg), this may causes death with chronic HIV-1 disease & bone marrow transplant. In this lethal condition therapy should be immediately stopped & monitor the indication due to this fetal case.

Acute renal failure :

Use Valcivir 500mg (Valacyclovir 500mg) in geriatric patients very cautiously. Dosage reduction should be necessary for renal impaired patients. Patients who are getting nephrotoxic medicine should be taken care while administration of Valcivir 500mg (Valacyclovir 500mg) tablets. Patients have no enough hydration may causes precipitation of acyclovir in renal tubules.

Drug interaction of Valcivir 500mg (Valacyclovir 500mg)

No drug- drug interactions occurs in the valacyclovir therapy.

Contraindication of Valcivir 500mg (Valacyclovir 500mg)

Valcivir 500mg (Valacyclovir 500mg) is highly contraindicated in patients with hypersensitivity reactions due to patients are contraindicated to the ingredients of Valcivir 500mg (Valacyclovir 500mg).

Pregnancy of Valcivir 500mg (Valacyclovir 500mg)

Pregnancy :

The pregnancy category of valacyclovir is B

It should be used with caution.

Caution should be taken while administering Valcivir 500mg (Valacyclovir 500mg) to nursing woman.

Dosage of Valcivir 500mg (Valacyclovir 500mg)

Valtrex tablet should be administered with or without food.

In adults :

Cold sore (herpes labialis): The prescribed dose of Valtrex is 2 gram should be taken for two times a day for one day in 12 hours apart. Genital herpes (initial episode): The prescribed dose of Valtrex is 1 grams should be taken as twice daily for 10 days. Recurrent episode: The prescribed dose is 500mg should be administered orally as twice daily for 3 days. Suppressive treatment: In ceaseless suppressive treatment, the recommended measurements are 1 gram taken as once every day in patients with typical capacities. In patients with 9 repeats for every year, the recommended dosage is 500mg ought to be regulated as once day by day. In HIV-1 infected patients: 500mg of Valtrex should be administered orally as two times a day. Reduction of transmission: 500mg of Valtrex should be taken as once daily. Herpes zoster: In this condition, the recommended dose of Valtrex is 1gm should be taen as three times a Day for 7 days.

In pediatrics :

Cold sores (herpes labialis): The patient’s age of greater or equal to 12 years, the recommended dose of Valtrex is 2 gram should be taken as twice daily for 1 day. Chicken pox: 20mg/kg of Valtrex should be administered orally as three times a day for 5 days. The maximum dose per day is not exceeding 1 gram 3times a day.

Storage of Valcivir 500mg (Valacyclovir 500mg)

The medicine stored at temperature of 15℃ to 25℃.

Protect the medicine away from moisture, heat & light.

Missed dose of Valcivir 500mg (Valacyclovir 500mg)

Missed dose condition should be avoided by maintain the regular dosing schedule. Do not skip the dose. Avoid self medication. If you missed dose, patient should be get advice from the medical practitioner & follow the instructions.

Brand name:
Valcivir
Active substance:
Valacyclovir
Strength:
500mg
Category:
Anti Viral
Manufacturer:
Cipla Ltd
Packaging:
3 Tablets
Product form:
Tablet

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