Afanat 40mg (Afatinib)

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Natco Pharma Ltd.

Afanat 40mg (Afatinib)

ManufacturerNatco Pharma Ltd.Brand nameAfanatInternational trade nameGilotrifActive substanceAfatinibStrength40mgCategoryAnti Cancer

Description of Afanat 40mg (Afatinib 40mg)

Afanat 40mg (Afatinib 40mg) belongs to quinazoline and butanamide derivative which acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER.
Afanat 40mg (Afatinib 40mg) is a prescription drugs which is used under the guidance of medical practioners.

Medical use /Indication of Afanat 40mg (Afatinib 40mg)

Afanat 40mg (Afatinib 40mg) is indicated for treatment a certain type of lung cancer (non-small cell lung cancer) which has spread to other parts of the body.

Mechanism of Action Afanat 40mg (Afatinib 40mg)

Afanat 40mg (Afatinib 40mg) blocking the activating sites called tyrosine kinases of various proteins within the cell. These proteins are most likely to develop cancer growth when the tumor includes the EGFR gene mutation. By stopping these targets, it will target the cancer will shrink.

Side effects of Afanat 40mg (Afatinib 40mg)

  • Loss of appetite
  • Nausea
  • Vomiting
  • Diarrhoea
  • Mouth sores
  • Acne
  • Itchiness
  • Rash
  • Dry skin
  • Nail infection

Serious side effects :

  • Breathing trouble
  • Cough and fever
  • Yellowing the skins
  • Brown coloured urine
  • Bleeding or bruising
  • Weakness
  • lurred vision
  • Fast heartbeat

Precautions of Afanat 40mg (Afatinib 40mg)


Mostnormal condition for people administrating this drug to have diarrhea. Certain situation this diarrhea can be serious. Severe diarrhea can cause dehydration and renal problems which can sometimes lead to death. During your treatment with Afanat 40mg (Afatinib 40mg), your doctor should also to treat diarrhea primarily.

Hepatic toxicity : Afanat 40mg (Afatinib 40mg) can worsen liver problems. Doctor will take blood tests to monitor the liver function before and during your treatment with this drug.

Keratitis: if patients confirm with suspected keratitis or ulcerative keratitis then stop or discontinue the drug

Interstitial lung disease (ILD) : Afanat 40mg (Afatinib 40mg) drug can leads to lung and breathing problems. Inform doctor right away about new or worsening lung problems while taking this drug. These problems can involveDyspnea, cough, or fever.

Bullous and exfoliative skin disorder : Afanat 40mg (Afatinib 40mg) can affect skin severely and show redness, rash, and acne. Inform doctor right away if you affected by severe skin reactions such as peeling or blistering.

Embryo-fetal toxicity:

Afanat 40mg (Afatinib 40mg) will cause harm to the foetus when administrated to pregnant women.

Drug interaction of Afanat 40mg (Afatinib 40mg)

Concomitant of Afanat 40mg (Afatinib 40mg) with P-gpinhibitors (cyclosporine A, ketoconazole verapamil) will increase exposure to Afatinib

Interaction of Afanat 40mg (Afatinib 40mg) with P-gpinducers (carbamazepine, phenytoin, phenobarbital) will decrease exposure to Afatinib

Pregnancy of Afanat 40mg (Afatinib 40mg)

When the drug Afanat 40mg (Afatinib 40mg) is administrated to a pregnant woman will harm the foetus.

Pregnancy should avoid while on treatment with Afanat 40mg (Afatinib 40mg).

Lactation of Afanat 40mg (Afatinib 40mg)

Afanat 40mg (Afatinib 40mg) Excretion into human milk is unknown or will have adverse reaction in a child who is breastfed. Therefore, decision should take whether to stop breastfeeding or discontinuation of medicine.

Dosage of Afanat 40mg (Afatinib 40mg)

Xovoltib the prescribed dose for the treatment of non-small cell lung cancer as follows :

For adult :

The prescribed dose is 40mg taken once per day.

For child dosage :

Ages of 0-17 years is not being studied in children.

The drug should not be used age under 18 years of age

For renal impairment:

prescribed dose is 30mg taken once per day

Take Xovoltib on an empty stomach. Consume the drug 1 hour before or 2 hours after a meal

Avoid cutting or crushing the tablet.

Storage of Afanat 40mg (Afatinib 40mg)

Afanat 40mg (Afatinib 40mg) Store at 25℃.

Keep Afanat 40mg (Afatinib 40mg) away from children.

Missed dose of Afanat 40mg (Afatinib 40mg)

If patient missed to take the dose of Afanat 40mg (Afatinib 40mg),the missed dose should be skipped and follow the regular dosing schedule. Do not self-medicate. Do not double the dose.

Brand name:
International trade name:
Active substance:
Anti Cancer
Natco Pharma Ltd
28 Tablets
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