Myezom 3.5mg (Bortezomib)

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Dr. Reddy’s Laboratories

Myezom 3.5mg (Bortezomib)

ManufacturerDr. Reddy’s LaboratoriesBrand nameMyezomInternational trade nameVelcadeActive substanceBortezomibStrength3.5mgCategoryAnti Cancer

Description  of  Myezom 3.5mg (Bortezomib 3.5mg)

Bortezomib is a drug sold under the brand name of Myezom 3.5mg (Bortezomib 3.5mg) which belongs to anti-neoplastic medicine, the main ingredient which is used as Bortezomib, which is available in the form of lyophilized powder Myezom 3.5mg (Bortezomib 3.5mg) is a prime benign proteasome inhibitor; proteasome is a biological structure that clefts the proteins Pharmacological grouped as: anti-neoplastic agent or proteasome inhibitor The drug is an prescription drug given under the supervision of pharmacist

INDICATIONS of  Myezom 3.5mg (Bortezomib 3.5mg)

Myezom 3.5mg (Bortezomib 3.5mg) is majorly indicated for the treatment for patients suffering by following disease. Multiple myeloma Mantle cell lymphoma

MECHANISM OF ACTION  of  Myezom 3.5mg (Bortezomib 3.5mg)

The drug Bortenat is a type of chymotrypsin like activity which is in form of unstable prohibitor of the 26S proteasome in human cells. The 26S proteasome is a group of protein that reduces the agglutinated proteins The various proteins are weakens by proteasome enzymes that make difficult to tumor cells persistence like cyclins, tumor suppressors, BCL-2 & cyclin dependent kinase inhibitors The functioning site of proteasome has Postglutamyl peptide hydrolysis activity Chymotrypsin like Trypsin like Prevention of these degenerations, sensitizes cells to apoptosis and cell arrest and leads to cell lysis

Absorption of  Myezom 3.5mg (Bortezomib 3.5mg)

The Myezom 3.5mg (Bortezomib 3.5mg) peak plasma level occurs as 509ng/ml

Distribution of  Myezom 3.5mg (Bortezomib 3.5mg)

The Myezom 3.5mg (Bortezomib 3.5mg) has nearly 83% of human plasma protein binding.

Metabolism of  Myezom 3.5mg (Bortezomib 3.5mg)

Primarily metabolic pathway of Myezom 3.5mg (Bortezomib 3.5mg) is occurs by deboronation to form 2-deboronated metabolites which are inactive as 26S proteasome inhibitors. In liver Myezom 3.5mg (Bortezomib 3.5mg) is metabolized with the help of cytochrome P 450 enzymes 3A4, 2C19, & 1A2 by oxidation

Excretion of  Myezom 3.5mg (Bortezomib 3.5mg)

The half life period of Myezom 3.5mg (Bortezomib 3.5mg) occurs at 9 to 15 hours In single dose IV;


 SIDE EFFECTS  of  Myezom 3.5mg (Bortezomib 3.5mg)

Most common side effects occurred after administration of Myezom 3.5mg (Bortezomib 3.5mg) includes; Burning, crawling, itching, numbness, prickling ; Chest pain ; Black tarry stools; Bleeding gums ; Blood in urine ; Blurred vision ; Body aches, dizziness, faintness, nerve pain, painful urination, pale skin, runny nose, sore throat, stuffy nose, swollen glands, sunken eyes, ulcer, dry mouth, Cough producing mucus, ear congestion, loss of voice

Belching, bone pain, difficulty with moving & bowel movements, cold and shivering, loss of appetite, loss of taste, muscle cramps, muscle pain, stomach discomfort. Vomiting, loss of weight discomfort, increased sensitivity of pain & touch, irregular breathing, heart beats, swelling of peripheral organs, thickening of bronchial secretions


PRECAUTIONS  of  Myezom 3.5mg (Bortezomib 3.5mg)

While taking Myezom 3.5mg (Bortezomib 3.5mg) some adverse effects occurs care should be taken in the conditions like Cardiac toxicity Pulmonary toxicity like Acute Respiratory Distress Syndrome, pneumonitis, interstitial pneumonia, lung infiltration. Posterior reversible encephalopathy syndrome-stop the Myezom 3.5mg (Bortezomib 3.5mg) therapy Myezom 3.5mg (Bortezomib 3.5mg) leads to peripheral neuropathy like burning sensation, hyperesthesia, hypoesthesia, paresthesia, neuropathic pain Manage postural Hypotension by altering the antihypertensive agents, hydration, and administration of mineralocorticoids or sympathomimetics Gastrointestinal toxicity-fluid or electrolyte replacements have to take Thrombocytopenia and neutropenia Tumor lysis syndrome Hepatic toxicity Embryo fetal toxicity

DRUG INTERACTION of  Myezom 3.5mg (Bortezomib 3.5mg)

Avoid interaction with st. Johns wort to decrease the exposure of Myezom 3.5mg (Bortezomib 3.5mg) while concomitant with CYP3A4 inhibitors: there is a chance of getting Myezom 3.5mg (Bortezomib 3.5mg) toxicity; so to reduce the dose of Myezom 3.5mg (Bortezomib 3.5mg) Interaction with Strong CYP3A4 inducers: decrease the exposure of Myezom 3.5mg (Bortezomib 3.5mg) while concomitant with melphalan-prednisone or dexamethasone alone No clinical effect on Myezom 3.5mg (Bortezomib 3.5mg) exposure.

CONTRAINDICATION of  Myezom 3.5mg (Bortezomib 3.5mg)

Myezom 3.5mg (Bortezomib 3.5mg) is administer through IV bolus or subcutaneous; whereas intrathecal administration is contraindicated to the patients who are receiving Bortezomib Hypersensitivity reaction occurs in patients who are contraindicated to Myezom 3.5mg (Bortezomib 3.5mg), boron, boric acid or glycine

PREGNANCY  & LACTATION  of Myezom 3.5mg (Bortezomib 3.5mg)

Myezom 3.5mg (Bortezomib 3.5mg) is not recommended in pregnancy condition. Myezom 3.5mg (Bortezomib 3.5mg) causes fetal harm and leads to some adverse effect Breast feeding is not recommended

DOSAGE of  Myezom 3.5mg (Bortezomib 3.5mg)

In adults:
Multiple myeloma :
Previously untreated multiple myeloma In the therapy: Myezom dose 1.3mg/m2 should be given as 3 to 5 seconds via IV bolus or subcutaneous by interacting with tablet melphalan and prednisolone for nine 6 weeks treatment cycles Myezom is taken for two times weekly, (day 1, 4, 8, 11, 22, 25, 29 and 32) for Cycles 1 over 4 Myezom is taken once a week (day 1, 8, 22, and 29) for Cycles 5 over 9 Duration of Myezom is 72 hours
In Relapse stage :
The usual dose of Myezom is 1.3mg/m2 should be given via IV bolus or subcutaneous as two times for two weeks (day1, 4, 8, and 11) followed by a ten day rest course (day 12 through 21) Schedule of Treatment increased above 8 cycles may be taken once weekly for 4 weeks (day 1, 8, 15, and 22), followed by 13 day rest (day 23 over 35)
Important points :
Myezom administrated alone or combination with dexamethasone therapy cycle require of Three week course

STORAGE  of  Myezom 3.5mg (Bortezomib 3.5mg)

Myezom 3.5mg (Bortezomib 3.5mg) vial should be stored at 20℃ to 25℃ (68℉ to 77℉); excursion between 15℃ to 30℃ (59℉ to 86℉) Keep away from light and heat

MISSED DOSE of  Myezom 3.5mg (Bortezomib 3.5mg)

If missed a dose the have it as soon possible or Missed dose should be swapped and continue the regular dosing schedule for avoiding adverse conditions. If missed dose occurs, it should not be resume and continue the next schedule.

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Anti Cancer
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