Tamtero 10mg (Tamoxifen)

Tamoxifen
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Hetero Drugs Ltd

Tamtero 10mg (Tamoxifen)

ManufacturerHetero Drugs LtdBrand nameTamteroInternational trade nameSoltamoxActive substanceTamoxifenStrength10mgCategoryAnti Cancer

Description  of  Tamtero 10mg (Tamoxifen 10mg)

Tamtero 10mg (Tamoxifen 10mg) is belongs to the anticancer agents and covered by film coated tablet, the drug also a nonsteroidal antiestrogen and work as a modulator with tissue selective activities for the treatment.
Tamtero 10mg (Tamoxifen 10mg)as a stimulating agent (estrogen) in metabolism of cholesterol, bone density, and cell replication in the endometrium.
Tamtero 10mg (Tamoxifen 10mg)will help for inhibition of estrogen receptor positive cancer.

INDICATIONS of  Tamtero 10mg (Tamoxifen 10mg)

Tamtero 10mg (Tamoxifen 10mg) is used to treat of early breast cancer in women whose been already treated with surgery, radiation, and chemotherapy.
Tamtero 10mg (Tamoxifen 10mg) will help to reduce the risk of developing a more serious type of breast cancer in women who had breast cancer that will not spread outer part of the milk duct where it forms (ductal carcinoma).

MECHANISM OF ACTION  of  Tamtero 10mg (Tamoxifen 10mg)

Tamtero 10mg (Tamoxifen 10mg) is a type of nonsteroidal agent which interlinked to estrogen receptors (ER), provoke a conformational change in the receptor. This results in a inhibits in the verbalization of estrogen based on genes.
Combine of Tamtero 10mg (Tamoxifen 10mg) is extended to the nuclear chromatin of these consequence will reduced DNA polymerase action, repair thymidine discharge and restriction uptake of estradiol, hence lowers estrogen response.
Tamtero 10mg (Tamoxifen 10mg) enough that to concomitant with other co activators or co repressors in the tissue and fuse with different estrogen receptors,

Absorption of  Tamtero 10mg (Tamoxifen 10mg)

The time to high plasma concentration is 40mg/ml and Tmax is 5 hours after dosing.

Distribution of  Tamtero 10mg (Tamoxifen 10mg)

not available

Metabolism of  Tamtero 10mg (Tamoxifen 10mg)

In hepatic Tamtero 10mg (Tamoxifen 10mg) is metabolized.

Excretion of  Tamtero 10mg (Tamoxifen 10mg)

Route of excretion is 30% via fecal and 65% was excreted from the body
Half-life is 5 to 7 days

 SIDE EFFECTS  of  Tamtero 10mg (Tamoxifen 10mg)

COMMON SIDE EFFECT:
• High tumor pain
• Tumor site forming reddening
• Hair thinning
• Weight loss
• Stomach pains
• Sexual ability lost
• Hot flashes
• Vertigo . Serious side effects may be as follows, immediately inform the doctor:
• Thirst
• muscle weakness
• restlessness
• loss of appetite
• Vision difficulty
• Fever
• Blisters
• Abscess on the, throat, face, lips, eyes, tongue, ankles or lower legs.

PRECAUTIONS  of  Tamtero 10mg (Tamoxifen 10mg)

Consult with the doctor or pharmacist as if you have allergic condition against Cytotam Tamtero 10mg (Tamoxifen 10mg) or any of the compound in Tamoxifen tablets.
• Consult with the doctor that you have or have ever had renal, hepatic, or cardiac problem
• Consult with the doctor that are you pregnant or plan to become pregnant. Do not have plan for children while on treatment with Tamtero 10mg (Tamoxifen 10mg). You must use a specific method of conceiving to prevent pregnancy in yourself or your partner during your treatment with Tamtero 10mg (Tamoxifen 10mg) the drug will harm the fetus.
• Avoid breast feeding while on treatment with Tamtero 10mg (Tamoxifen 10mg)
• Use drug with caution due to early breast cancer signs hence during treatment with tamoxifen aware about development of breast cancer.
• Some important precautions should take care
• Effects in Metastatic breast cancer Patients
• Some breast cancer patients may report from hypercalcemia by starting few weeks treatment, if the condition occur and became severe then tamoxifen should discontinue.
• Effects on the Uterus-Endometrial Cancer and Uterine Sarcoma
• An incidence may increase with uterine malignancies and endometrial carcinoma is resulted with tamoxifen treatment.
• Non-malignant Effects on the uterus
• Due to estrogen properties of tamoxifen, an increased incidence of endometrial changes occurs involves like hyperplasia and polyps has been resulted. Hence the drug causes menstrual irregularity or amenorrhea.

DRUG INTERACTION of  Tamtero 10mg (Tamoxifen 10mg)

While interaction of Tamtero 10mg (Tamoxifen 10mg)with coumarin type anticoagulants combination will leads to increase in anticoagulant effects may occur.
Concomitant use of Bromocriptine with Tamtero 10mg (Tamoxifen 10mg)will increase the serum level of Tamtero 10mg (Tamoxifen 10mg) and N-desmethyl tamoxifen.

OVERDOSAGE of Tamtero 10mg (Tamoxifen 10mg)

Acute overdose is not considered in humans, in animals If administer heavy dose then leads in respiratory difficulties and convulsions and in human unsteady gait, acute neurotoxicity manifested by tremor, hyperreflexia, and vertigo was reported. There is no essential treatment for overdose. Thereby provide the patients by symptomatic supportive measures

 

CONTRAINDICATION of Tamtero 10mg (Tamoxifen 10mg)

Tamtero 10mg (Tamoxifen 10mg)is contraindicated in patients with as follows:
• Known hypersensitivity to the drug or its any ingredients
• Women concomitant use with coumarin- type anticoagulant treatment
• In women with deep vein thrombosis or pulmonary embolus history.

PREGNANCY  & LACTATION  of Tamtero 10mg (Tamoxifen 10mg)

Category D: Tamtero 10mg (Tamoxifen 10mg) while recommended to pregnant women will cause harm to fetal. Women are advised to stop the drug within 2 months and not become pregnant while taking Tamtero 10mg (Tamoxifen 10mg). And If sexually active then should use non-hormonal contraceptive measures.

DOSAGE of  Tamtero 10mg (Tamoxifen 10mg)

Regular adult dose for :
20 to 40mg for 5 years daily administer orally for breast cancer doses is > 20mg given by dividing dose (morning and evening) 20mg 5 years daily given orally for DCIS followed by surgery and radiation on breast
For 5 years administer 20mg daily taken orally to decrease the action of breast cancer in women at increased risk for breast cancer 20mg OD orally or 10mg twice daily orally given for adult dose for adjuvant breast cancer and Duration: 5 years
Pediatric dose for :
girls 2 to 10 years :
20mg once daily via oral route; duration up to 12 months administrated for McCune- Albright syndrome
20mg once daily via oral route; duration up to 12 months given for Precocious Puberty


STORAGE  of  Tamtero 10mg (Tamoxifen 10mg)

Keep away from children
Do not freeze
Keep the drug in a closed container at room temperature.


MISSED DOSE of  Tamtero 10mg (Tamoxifen 10mg)

Have the missed dose immediately before next dose duration
Next dose time arrived then left off the missed dose and follows regular schedule.
Avoid taking extra dose at same time.
Please consult the doctor for further details.

Brand name:
Tamtero
International trade name:
Soltamox
Active substance:
Tamoxifen
Strength:
10mg
Category:
Anti Cancer
Manufacturer:
Hetero Healthcare Ltd
Packaging:
10 tablets
Product form:
Tablet

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