Xovoltib 30mg (Afatinib)

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Brand nameXovoltibInternational trade nameGilotrifActive substanceAfatinibStrength30mgCategoryAnti Cancer

Description  of  Xovoltib 30mg (Afatinib 30mg)

Xovoltib 30mg (Afatinib 30mg) belongs to quinazoline and butanamide derivative which acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER.
Xovoltib 30mg (Afatinib 30mg) is a prescription drugs which is used under the guidance of medical practioners.

INDICATIONS of  Xovoltib 30mg (Afatinib 30mg)

Xovoltib 30mg (Afatinib 30mg) is indicated for treatment a certain type of lung cancer (non-small cell lung cancer) which has spread to other parts of the body.

MECHANISM OF ACTION  of  Xovoltib 30mg (Afatinib 30mg)

Xovoltib 30mg (Afatinib 30mg) blocking the activating sites called tyrosine kinases of various proteins within the cell. These proteins are most likely to develop cancer growth when the tumor includes the EGFR gene mutation. By stopping these targets, it will target the cancer will shrink.

 SIDE EFFECTS  of  Xovoltib 30mg (Afatinib 30mg)

  • Loss of appetite
    • Nausea
    • Vomiting
    • Diarrhoea
    • Mouth sores
    • Acne
    • Itchiness
    • Rash
    • Dry skin
    • Nail infection
    Serious side effects :
    • Breathing trouble
    • Cough and fever
    • Yellowing the skins
    • Brown coloured urine
    • Bleeding or bruising
    • Weakness
    • Blurred vision
    • Fast heartbeat

PRECAUTIONS  of  Xovoltib 30mg (Afatinib 30mg)

mostnormal condition for people administrating this drug to have diarrhea. Certain situation this diarrhea can be serious. Severe diarrhea can cause dehydration and renal problems which can sometimes lead to death. During your treatment with Xovoltib 30mg (Afatinib 30mg), your doctor should also to treat diarrhea primarily.
Hepatic toxicity : Xovoltib 30mg (Afatinib 30mg) can worsen liver problems. Doctor will take blood tests to monitor the liver function before and during your treatment with this drug.
Keratitis: if patients confirm with suspected keratitis or ulcerative keratitis then stop or discontinue the drug
Interstitial lung disease (ILD) : Xovoltib 30mg (Afatinib 30mg) drug can leads to lung and breathing problems. Inform doctor right away about new or worsening lung problems while taking this drug. These problems can involveDyspnea, cough, or fever.
Bullous and exfoliative skin disorder : Xovoltib 30mg (Afatinib 30mg) can affect skin severely and show redness, rash, and acne. Inform doctor right away if you affected by severe skin reactions such as peeling or blistering.
Embryo-fetal toxicity:
Xovoltib 30mg (Afatinib 30mg) will cause harm to the foetus when administrated to pregnant women.

DRUG INTERACTION of  Xovoltib 30mg (Afatinib 30mg)

Concomitant of Xovoltib 30mg (Afatinib 30mg) with P-gpinhibitors (cyclosporine A, ketoconazole verapamil) will increase exposure to Afatinib
Interaction of Xovoltib 30mg (Afatinib 30mg) with P-gpinducers (carbamazepine, phenytoin, phenobarbital) will decrease exposure to Afatinib

PREGNANCY  of Xovoltib 30mg (Afatinib 30mg)

When the drug Xovoltib 30mg (Afatinib 30mg) is administrated to a pregnant woman will harm the foetus.

Pregnancy should avoid while on treatment with Xovoltib 30mg (Afatinib 30mg).


LACTATION  of Xovoltib 30mg (Afatinib 30mg)

Xovoltib 30mg (Afatinib 30mg) Excretion into human milk is unknown or will have adverse reaction in a child who is breastfed. Therefore, decision should take whether to stop breastfeeding or discontinuation of medicine.

DOSAGE of  Xovoltib 30mg (Afatinib 30mg)

Xovoltib the prescribed dose for the treatment of non-small cell lung cancer as follows :
For adult :
The prescribed dose is 40mg taken once per day.
For child dosage :
Ages of 0-17 years is not being studied in children.
The drug should not be used age under 18 years of age
For renal impairment:
prescribed dose is 30mg taken once per day
Take Xovoltib on an empty stomach. Consume the drug 1 hour before or 2 hours after a meal
Avoid cutting or crushing the tablet.

STORAGE  of  Xovoltib 30mg (Afatinib 30mg)

Xovoltib 30mg (Afatinib 30mg) Store at 25℃.
Keep Xovoltib 30mg (Afatinib 30mg) away from children.

MISSED DOSE of  Xovoltib 30mg (Afatinib 30mg)

If patient missed to take the dose of Xovoltib 30mg (Afatinib 30mg),the missed dose should be skipped and follow the regular dosing schedule. Do not self-medicate. Do not double the dose.

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Anti Cancer
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