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PRODUCT DETAILS

Brand name : Gemtaz
Strength : 1gm
Active substance : Gemcitabine
Manufactured by : Sun Pharmaceuticals
Pack : 1 injection in a vial

for MORE INFORMATION !!!

Gemcitabine is generic name of brand name Gemtaz and Gemcitabine is a cancer medicine that inhibits the growth and spread of cancer cells in the body.
Gemtaz 1gm administered into a vein by slow injection.
Gemtaz 1gm is a prescription drug which is used under the supervision of medical oncologist

INDICATION

Gemcitabine is generic name of brand name Gemtaz and Gemcitabine is a cancer medicine that inhibits the growth and spread of cancer cells in the body.
Gemtaz 1gm administered into a vein by slow injection.
Gemtaz 1gm is a prescription drug which is used under the supervision of medical oncologist

DOSAGE

Pancreatic cancer :
The recommended dose is 1000mg/m2 IV infusion over 30 min once weekly x 7 weeks; rest 1 week
And the dose 1000mg/m2IV once weekly for 3 weeks of each 28-day cycle
Non-small cell lung cancer :
The recommended dose is 1000mg/m2IV infusion over 30 minutes on days 1,8 and 15 of each 28-day cycle or
The recommended dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Administer cisplatin 100mg/m2 IV after gemcitabine on day 1
Breast cancer :
The recommended dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Dose with paclitaxel 175mg/m2 on day 1 as a 3-hr infusion before gemcitabine
Ovarian cancer:
The recommended dose is 1000 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle.
Dose with carboplatin AUC 4 on day 1 after gemcitabine

MECHANISM

Gemcitabine is a family of drugs called antimetabolites which inhibits the DNA production. Antimetabolites are very same to common substances within the cell. This discontinue cell growth and division, reporting in the reducing or blocking of cancer growth. Since cancer cells, in general, replicate faster and with less error-correcting than healthy cells, cancer cells are more conscious to this damage. Gemcitabine kills cancer cells go through DNA synthesis. It interferes with ribonucleotide reductase, an enzyme important to DNA combination. Because cells cannot duplicate their DNA, they cannot properly multiply, and thus die.

ADME

By infusion length the volume of distribution is increased Vd: 50 L/m2
Metabolized by transformed through nucleoside kinases to two active metabolites such as gemcitabine diphosphate and gemcitabine triphosphate
The drug is excreted through urine (92-98%) and Half-life of Gemtaz is 1.7-19.4 hr

PRECAUTION

With Gemtaz 1gm treatment Capillary leak syndrome resulted with serious consequences; discontinue if symptoms occur
Haemolytic uremic syndrome resulted, containing fatalities; permanently stop treatment in patients with HUS or serious kidney impairment; Kidney failure may not be reversible even with stop of therapy
Drug-induced liver injury resulted, involving liver failure and death; assess hepatic function before to initiation of therapy and periodically during treatment; stop drug in patients which develop severe liver injury
When Gemtaz 1gm in combination with carboplatin or paclitaxel: patients should have ANC >1.5 x 10^6/mL and platelet count >10^8/mL prior to each cycle

DRUG INTERACTION

No drug interaction studies have been conducted

CONTRAINDICATION

Hypersensitivity

STORAGE

The drug Gemtaz 1gm Store at 20 ℃ to 25 ℃ (68 ℃ to 77℉)

MISSED DOSE

If failed to take dose, then have the missed dose as soon as possible before next dose time reaches or skip the dose and follow the normal schedule
Consult the doctor

SIDE EFFECTS

Common side effects :
• Cough.
• Blocked or runny nose.
• Sweating.
• Back pain.
• Myalgia.
• Chills and fever.
• Weakness
• Loss of appetite.
• Headache.
• Insomnia
• Sleepiness.
• Mouth ulcers.
• Diarrhoea or constipation.
Very common side effects :
• Dyspnea.
• Alopecia
• Allergic skin rash.
• Cold or flu-like symptoms.
• Retention of fluid in the body
• Abnormal results in liver function tests.
• blood in the urine or protein presence

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