Brand name : Gemtaz
Strength : 200mg
Active substance : Gemcitabine
Manufactured by : Sun Pharmaceuticals
Pack : 1 injection in a vial


Gemcitabine is generic name of brand name Gemtaz and Gemcitabine is a cancer medicine that inhibits the growth and spread of cancer cells in the body.
Gemtaz 200mg administered into a vein by slow injection.
Gemtaz 200mg is a prescription drug which is used under the supervision of medical oncologist


Gemtaz 200mg is indicated for the treatment for Non-small cell lung cancer which is locally advanced or has spread to other areas of the body.
Gemtaz 200mg is indicated for the treatment for Cancer of the pancreas which is locally advanced or has spread to other areas of the body.
Gemtaz 200mg is indicated for the treatment for Bladder cancer that is locally advanced or has spread to other areas of the body.
Gemtaz 200mg is indicated for the treatment for Breast cancer that has returned or spread to other areas of the body and is not suitable for surgery, in people whose cancer has relapsed following previous chemotherapy.
Gemtaz 200mg is indicated for the treatment for Ovarian cancer which is locally advanced or has spread to other areas of the body.


Pancreatic cancer :
The recommended dose is 1000mg/m2 IV infusion over 30 min once weekly x 7 weeks; rest 1 week
And the dose 1000mg/m2IV once weekly for 3 weeks of each 28-day cycle
Non-small cell lung cancer :
The recommended dose is 1000mg/m2IV infusion over 30 minutes on days 1,8 and 15 of each 28-day cycle or
The recommended dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Administer cisplatin 100mg/m2 IV after gemcitabine on day 1
Breast cancer :
The recommended dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Dose with paclitaxel 175mg/m2 on day 1 as a 3-hr infusion before gemcitabine
Ovarian cancer :
The recommended dose is 1000 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle. Dose with carboplatin AUC 4 on day 1 after gemcitabine


Gemcitabine is a family of drugs called antimetabolites which inhibits the DNA production. Antimetabolites are very same to common substances within the cell. This discontinue cell growth and division, reporting in the reducing or blocking of cancer growth. Since cancer cells, in general, replicate faster and with less error-correcting than healthy cells, cancer cells are more conscious to this damage. Gemcitabine kills cancer cells go through DNA synthesis. It interferes with ribonucleotide reductase, an enzyme important to DNA combination. Because cells cannot duplicate their DNA, they cannot properly multiply, and thus die.


By infusion length the volume of distribution is increased Vd: 50 L/m2
Metabolized by transformed through nucleoside kinases to two active metabolites such as gemcitabine diphosphate and gemcitabine triphosphate
The drug is excreted through urine (92-98%) and Half-life of Gemtaz is 1.7-19.4 hr


With Gemtaz 200mg treatment Capillary leak syndrome resulted with serious consequences; discontinue if symptoms occur
Haemolytic uremic syndrome resulted, containing fatalities; permanently stop treatment in patients with HUS or serious kidney impairment; Kidney failure may not be reversible even with stop of therapy
Drug-induced liver injury resulted, involving liver failure and death; assess hepatic function before to initiation of therapy and periodically during treatment; stop drug in patients which develop severe liver injury
When Gemtaz 200mg in combination with carboplatin or paclitaxel: patients should have ANC >1.5 x 10^6/mL and platelet count >10^8/mL prior to each cycle


No drug interaction studies have been conducted




The drug Gemtaz 200mg Store at 20 ℃ to 25 ℃ (68 ℃ to 77℉)


If failed to take dose, then have the missed dose as soon as possible before next dose time reaches or skip the dose and follow the normal schedule
Consult the doctor


Common side effects :
• Cough.
• Blocked or runny nose.
• Sweating.
• Back pain.
• Myalgia.
• Chills and fever.
• Weakness
• Loss of appetite.
• Headache.
• Insomnia
• Sleepiness.
• Mouth ulcers.
• Diarrhoea or constipation.
Very common side effects :
• Dyspnea.
• Alopecia
• Allergic skin rash.
• Cold or flu-like symptoms.
• Retention of fluid in the body
• Abnormal results in liver function tests.
• blood in the urine or protein presence

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