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PRODUCT DETAILS

Brand Name : Herceptin
Composition : Trastuzumab
Strength availability : 440mg
Manufactured by : Roche
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Herceptin is a group of medicines which belongs to anti neoplastics medication.
Herceptin is a chemotherapy drug. It is recommended that Herceptin be administered under the guidance of a qualified physician experienced in the use of cancer chemotherapeutic agents.

INDICATION

The injection Herceptin is used alone or combination with other medicine for the treatment in patients who suffering from metastatic breast cancer.
The drug also indicated with combination of other medicine for the treatment of certain types of stomach or esophagus cancer in some persons.

MECHANISM

Different type of breast cancer cells have a higher than normal level of a protein called HER2 (human epidermal growth factor receptor 2) on their surface. These HER2 receptors get signals which stimulate the tumor cells to develop and reproduce. But breast cancer cells with too many HER2 receptors can Choice too many growth signals and so start developing and proliferating too much and too fast.
Herceptin acts by adhere itself to the HER2 receptors on the surface of breast cancer cells and stopping them from collecting growth signals. By stopping the signals, Herceptin can slow or inhibit the growth of the breast cancer and the drug is an immune targeted therapy. In addition to inhibiting HER2 receptors, Trastuzumab can also help to fight against breast cancer by attentive the immune system to damage the cancer cells onto which it is attached.

DOSAGE

The injection Herceptin should not mix with other drugs and do not administer as an intravenous push or bolus.
Trastuzumab should not be substitute for or with ado-Trastuzumab emtansine
Adjuvant treatment, breast cancer:
The drug given according to one of the following doses and schedules for a 52 weeks total of trastuzumab treatment:
During combination with paclitaxel, docetaxel, or docetaxel /Carboplatin:
Starting dose of 4 mg/kg as an IV (intravenous infusion) over 90 minutes followed at 2 mg/kg as an IV( intravenous infusion) over 30 minutes weekly during treatment of chemotherapy given with paclitaxel or docetaxel for first 12 weeks or 18 weeks (docetaxel/carboplatin)
The Herceptin dose for One week following the last weekly administers Trastuzumab at 6 mg/kg as an IV (intravenous infusion) over 30 to 90 minutes every three weeks.
The injection given as a single agent within three weeks following completion of multi-modality,
anthracycline-based chemotherapy regimens:
For an intravenous infusion over 90 minutes: Initial dose at 8 mg/kg
Successive doses at 6 mg/kg over 30 to 90 minutes every three weeks as an intravenous infusion.
Adjuvant treatment stretching beyond one year is not recommended.
Metastatic Treatment, Breast Cancer:
Herceptin administrated alone or in combination with paclitaxel, at an starting dose of 4 mg/kg as a 90-minute intravenous infusion continued by successive once weekly doses of 2 mg/kg as 30-minute intravenous infusions until disease development.
Metastatic Gastric Cancer:
Herceptin administrated at an starting dose of 8 mg/kg as a 90 minute IV intravenous infusion continued by successive doses of 6 mg/kg as an intravenous infusion over 30 to 90 minutes every three weeks until disease development.

SAFETY MEASURES

Embryo fetal damage :
Herceptin is contraindicated to pregnancy period.
Avoid becoming pregnancy during this therapy.
Use efficient contraceptives during treatment
Cardiomyopathy :
Patient getting Herceptin injection have increased risk of exposing to cardiac disorders.
Provide alternative therapy management
In serious condition, treatment should be discontinue
Pulmonary toxicity :
Some serious fatal cases of pulmonary toxicity occur during Herceptin treatment.
Infusion reactions :
During Herceptin treatment some life threatening infusion reactions are produced.
In serious infusion reactions, Stop the Herceptin treatment permanently.
Patient should be treated with premedication before starting the infusion to overcome the such problem, During Herceptin treatment.use with Caution.
Therapy induced neutropenia :
Higher incidence of neutropenia occurs during Herceptin treatment.

DRUG INTERACTION

In some phenomenal condition, patient should get anthracycline, in that situation patient’s cardiac function should be checked carefully with regular intervals.
Do not take anthracycline treatment for 7 months after stopping the Herceptin treatment.
Herceptin interaction with anthracycline after ending of Herceptin treatment may have a chance of getting cardiac problem. This side effects occur because of Trastuzumab great disaster period is depends on population PK analysis.

CONTRAINDICATION

Probably no contraindicated occurs.
The patients are contraindicated to the component present in the Herceptin, Hence Hypersensitivity reactions are occurs.

MISSED DOSE

The drug Missing doses can decrease their usefulness and raises the probability of developing drug resistance, that makes this drug lose their potency. For best results, it is important to accept each scheduled dose of Trastuzumab medication as instructed. If you miss a dose, leave the missed dose and continue with your regular dosing schedule. Do not have two doses to make up for a missed one. If you are not sure about what to do after missing a dose, the take advice with doctor or pharmacist.

STORAGE

Store the drug at 2℃ to 8℃ (refrigerator temperature)
Protected the vial away from heat & light
Stored at 2℃ to 8℃ for 28 days after reconstitution
Stored Herceptin diluted bag at 2℃ to 8℃ for 24 hours.

LACTATION

Normally, if you are pregnant and administrating Herceptin injection, one of your greatest worry will be for your unborn child. Because, during pregnancy this cancer medicine may be harmful for your baby. So, if this drug is used during pregnancy, or if the patient becomes pregnant while taking this medicine, the patient should be advice about the hidden hazard to a fetus. You should tell about your pregnancy to your doctor. Your pharmacist must understand your condition in order to check your health, and then your baby will be protected from infection soon after birth. You can also discuss with your doctor about birth control methods that will work for you.

SIDE EFFECTS

Common side effects:
Redness at injection site (IV)
Muscle/joint/back pain
Insomnia
Tiredness
Mild skin rash
Stuffy nose
Sinus pain
Serious side effects:
Increased coughing
Sudden unexplained weight gain
Unusual tiredness
Easy bruising or bleeding
Fast or pounding heartbeat
Increased coughing

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