Brand name : Irnocam
Strength : 100mg
Active substance : Irinotecan
Manufactured by : Dr. Reddy’s Laboratories
Pack : 1ml in a vial


Irnocam 100mg is a camptothecin derivative that exerts antitumor activity against a variety of tumors. The active metabolite of Irnocam is SN-38 produced in the body by carboxylesterase.
Irnocam 100mg is used to cure cancers of the colon and rectum. It is usually administering with other chemotherapy medicines in a combination chemotherapy.
Irnocam 100mg is a prescription drugs which is used under supervision by medical physician


Irnocam 100mg is mainly used for the treatment in patients with metastatic colon or rectal cancer.


Colorectal cancer :
Monotherapy dosage :
Premediate the patients with antiemetic agents
For experience cholinergic symptoms in patient’s atropine treatment should be considered
Dose 1: 125mg/m2 IV infusion over 90 minutes on days 1,8,15,22, then 2 weeks off then repeat administrated weekly
Dose 2: 350mg/sq. meter IV Infusion over 30-90 minutes q3weeks administrated once every 3 weeks.
Combination therapy :
Premediate the patients with antiemetic agents
For experience cholinergic symptoms in patient’s atropine treatment should be considered
Dose 1: 180mg/m2 IV infusion over 30-90 minutes once on days 1,15, and 29, then followed by infusion with leucovorin and 5- fluorouracil; next cycle begins on day 43
Dose 2: 125mg/sq. meter on days 1,8,15 and 22 IV Infusion over 90 minutes then followed by bolus doses of leucovorin and 5-fluorouracil


Camptothecin is a derivative of irinotecan which interact particularly with the enzyme topoisomerase I, which relieves torsional strain in DNA by activating reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and inhibits relocation of these single-strand breaks. The cytotoxicity of Irinotecan is because of double-strand DNA injury produced during DNA combination when multiplication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot expertly repair these double strand breaks.


Irnocam 100mg has time to Peak Plasma Concentration of Irnocam 100mg is 1660 ng/mL; SN-38 26.3 ng/mL
Irnocam 100mg has Protein Bound: 30-68%; SN-38 95% and Vd: 110-234 L/m²
Irnocam 100mg is mainly metabolized in hepatic, to SN-38; SN-38 is further metabolized by UGT1A1 and metabolites are metabolized to SN-38
Excretion of Irnocam 100mg through urine, feces
Half-Life of Irnocam: 6-12 hr; SN-38 10-20 hr


• Drug Irnocam 100mg is exposed to photodegradation, specifically in neutral & alkaline solutions
• When treatment will cause Hyperbilirubinemia, elderly, receiving radiation therapy, abdominal/pelvic radiation history
• Not for use in concomitant with a regimen of 5-FU/LV administered for 4-5 consecutive days every 4 weeks outside of a clinical study
• While on Irnocam treatment interstitial pulmonary disease (IPD)-like events, contains fatalities, have been resulted (in combination and as monotherapy) for treatment of colorectal cancer and other advanced solid tumors
• Risk of both early and late forms of diarrhea will occurs on treatment with Irnocam
• Risk of serious myelosuppression; manage febrile neutropenia immediately with antibiotic support; discontinue therapy and decrease subsequent doses if necessary


• When interaction of Irnocam 100mg with 5-fluorouracil and leucovorin (LV), the disposition of irinotecan was not substantially altered.
• Co administration of Irnocam 100mg with strong CYP34A inducers do not administer unless there are no therapeutic alternatives
• When concomitant use of Irnocam 100mg with strong CYP34A inhibitors may increase systemic exposure to irinotecan or SN-38


Irnocam 100mg contraindicated in patients with known hypersensitivity to the drug or its excipients


Irnocam 100mg is Store at 20 ℃ to 25 ℃
Protect from light
Keep in its original vial until the time of use


Common side effects of Irnocam 100mg :
Anxiety, Black, tarry stools, Changes in skin colour, Bruising, Chest pain, Decrease appetite, Confusion, Constricted pupils, Hoarseness, Dark urine , Hair loss, Mouth ulcers, Tummy pain.
Serious side effects of Irnocam 100mg :
Decreased amount of urine, Troubled breathing, Hives , Rapid weight gain, Constipation, Liver changes, Increased blood pressure, Swelling around the drip site, Skin rash, Dizziness, Blood clots.


If dose is missed, then take the dose immediately before reach of next dose time or leave the missed dose and follow the normal schedule. Avoid have extra dose which leads to over dosage
Consult the doctor about missed dose and overdose

We'd Like to Hear From You!


1., a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from
6. At, a Caregiver can order prescription medicines on your behalf.

This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.