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Isentress-400mg

PRODUCT DETAILS

Trade name : Isentress
Active ingredient : Raltegravir
Strength availability : 400mg
Manufactured by : MSD
Package : 60 tablets in a container
Category : Anti-retroviral drug.

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Raltegravir is chemically sort by type as derivative of pyrrolidinone. Isentress tablets are belongs to as anti-retroviral medicine by involving an active ingredient known as Raltegravir which is efficient against HIV infection. Isentress tablets are pharmacologically classified as an inhibitor of integrase. Isentress may used in Co-administration with other anti-retroviral drugs for producing beneficial activity. Isentress tablets are prescription regimen, which is used only under guidance of medical practitioner.

USAGE

Isentress tablets are indicated to treat of HIV-1 infection by concomitant use with other anti-retroviral medicines. Hence the evidence is based on investigating the plasma HIV-1 RNA levels. The usage of Isentress is based on evalution of safety, tolerability, pharmacokinetic parameters & efficacy of Raltegravir.

DOSAGE

Isentress tablet should be taken with or without food. In adult, the usual dose is 400mg of Isentress should be given as a two times a day. In pediatrics; 12 years or older: The usual dose is 400mg of Isentress should be consumed as two times a day. 6 to less than 12 years of age: At least 25kg: One tablet of Isentress 400mg should be taken orally administer as two times a day ≥ 40kg: the drug Isentress 400mg should be administered two times a day.

PHARMACOLOGY

Isentress consist of Raltegravir targeted the integrase which is an enzyme that assimilate the viral genetic material into human chromosome, a demanding step in HIV pathogenesis.

ADME

Absorption: high plasma concentration time is almost 3 hours.
Distribution: Raltegravir is largely bound to human serum protein by 83%. The drug is dispersed in red blood cells at minor range.
Metabolism :
Majorly in liver metabolism of Isentress is occurs
Excretion :
The Raltegravir excretion route is occurs through feces & urine. The Raltegravir half life period is 9 hours.

PRECAUTION

Immune reconstitution syndrome: This lethal condition is generally occurred in patients who are receiving anti-retroviral treatment. Give safety measures In severe condition, stop the treatment. Phenylketonurics: Raltegravir is a chewable medication which consist of a component like phenylalanine (aspartame component) which is responsible for this fatal case. Severe skin reactions & anaphylactic reactions: Skin reactions like Stevens Johnson syndrome & toxic epidermal necrolysis are some of fatal cases occur. Provided life threatening condition, therapy should be discontinue and provide the general supportive therapy. Clinical wise status should be suitably monitored for decreasing the manifestations.

DRUG INTERACTION

Interaction with atazanavir causes increasing the concentration of Raltegravir. The drug Raltegravir is not prevents the CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 or 3A. Raltegravir not prevents the P-gp mediated transport. Isentress tablets are interaction with rifampin leads to depletion of plasma concentration of Raltegravir. In case of this consolidation, the dose of Isentress should be increased for lowering this adverse problem. Interaction of Isentress with atazanavir/ritonavir, causes increasing concentration of Raltegravir Concurrently use of Isentress tablets with Efavirenz leads to cause decreasing the concentration of Raltegravir. Interaction of Isentress tablets with tipranavir/ritonavir, causes deminish the effect of concentration of Raltegravir. Co administration with gastric regulators should be avoided, because this combination leads to increase the effect of concentration of Raltegravir.

OVERDOSAGE

The highest dose of Isentress is 1600mg as a single dose The highest dose of Isentress is 800mg as two times a day. Even if over dosage of Isentress occur patient must be; Start with supportive measures and excrete the unabsorbed dose from GI tract. Monitor the manifestation occurs due to over dosage

MISSED DOSE

Isentress is an anti-retroviral medicine, On condition of missed dose, the patient should be consult with medical practitioner and maintain the guidance Or skip missed dose and Maintain the regular dosing schedule

SIDE EFFECTS

While using with drug most people affect with some side effect. Some of them are listed below :
Decreased in platelets count , Elevation of blood glucose level, Increased bilirubin, Increased serum AST, ALT, Increased alkaline phosphatase, Insomnia, Abnormal dreams, Fatigue, Neutropenia, Anemia, Headache, Nausea, Asthenia, Abdominal pain, Gastritis, Hepatitis, Hypersensitivity, Stevens Johnson syndrome, Herpes zoster, Dizziness, Renal failure, Suicidal ideation, Rash.

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