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lenalid-10mg

PRODUCT DETAILS

Brand name : Lenalid
Strength : 10mg
Active substance : Lenalidomide
Manufactured by : Natco pharma
Pack : 30 capsules in a container
Category : Anti-neoplastic drug

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Lenalid(lenalidomide ) is belongs to anticancer medication which contains Lenalidomide as an active substance which belongs to thalidomide analogue, the main ingredient which is used as lenalidomide . Lenalid 10mg is used to the disease condition by combining with dexamethasone. Lenalid 10mg(lenalidomide ) consist of some other pharmacological activities like immuno modulatory & anti-angiogenesis. Lenalid 10mg is a prescription drug that can only use under the supervision of medical oncologist.

INDICATION

The indications of Lenalid 10mg are; Lenalid(lenalidomide ) combination with dexamethasone is indicated to treat the patients suffered from multiple myeloma Lenalid is indicated for the patients having transfusion-dependent anemia because of intermediate 1 risk myelodysplastic syndrome along with deletion 5q cytogenetic abnormality without or without addition cytogenetic abnormalities Lenalid(lenalidomide ) is used to treat the patients with mantle cell lymphoma in which its used whose the disease was relapsed or progressed after two before treatment, especially the disease not response with the bortezomib therapy.

MECHANISM

Lenalid 10mg involves in the prudence of tumor and factor alpha arrangement, that reinforcement the T-cells and leads to lessening plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast growth factor. Lenalid 10mg(lenalidomide ) is moreover engaged with the stave off angiogenesis. Lenalidomide is furthermore authorize G1 cell cycle capture and apoptosis of ruinous cells.

The adult usual dose of Lenalid 10mg in myelodysplastic syndromes is 10mg and adminisrated once a day. For renal damaged patients; CrCl>60ml/min In Patients should not needed dosage adjustment of Lenalid(lenalidomide ) CrCl 30 to 60ml/min In Patients, 10mg of Lenalid should administre orally as once daily CrCl<30ml/min In Patient, 2.10mg of Lenalid(lenalidomide ) should be given orally as a once daily. Dosage variation;
Thrombocytopenia:
Drops to <50000/mcL, treatment should be interrupted. Back to > or equal to 50000/mcL, follow the Lenalid of 10mg per day.
Neutropenia;
Drops to <500/mcL, treatment should be delayed. Back to > or equal to 500/mcL, treatment should be follow to 10mg per day.
Multiple myeloma;
In this disease, concomitant use of dexamethasone with lenalid(lenalidomide ). The regular dose of Lenalid is 210mg should be given as once in a day on day 1 to 21. The dose of dexamethasone; Dexamethasone 40mg should be continued on day 1 to 4, 9 to 12 & 17 to 20 of each period of 28-day cycles. Patient with greater than 75 years, dexamethasone 20mg should be prescribed on day 1, 8, 15, & 22.

PHARMACOKINETICS

Absorption:
absorbed rapidly withpeak plasma concentration is between 0.625 and 1.5 hrs. combining with food will not change the prolong of absorption but dose decrease in Cmax.
Distribution:
bounding of plasma protein is 30%
Metabolism:
mainly metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide.
Excretion:
primarily eliminated in renal route and the dose excreted via urine 90% and feces 4% and half-life is 3hrs

MANTLE CELL LYMPHOMA

The usual dose of Lenalid for this disease is 210mg should be given orally as once daily. For renal damaged patients; CrCl 30 to 60ml/min in patient, Lenalid 10mg(lenalidomide ) should be given as once daily. CrCl<30ml/min in patients, Lenalid 10mg should be used for q48hr. Pediatrics; The safety & efficiency of Lenalidomide has not been decribed in pediatric patients with age of <18 years.

WARNING

Venous & arterial thromboembolism
Blood clotting effects
Embryo fetal damage
Hypersensitivity reactions
Hematological disorders
For all these conditions, some supportive measures should be used and provide safety measures.

CONTRAINDICATION

When pregnancy period the drug is contraindicated The patients are contraindicated to hypersensitivity reaction and the Lenalid 10mg(lenalidomide ) component.

MISSED DOSE

The missed dose of Lenalid 10mg(lenalidomide ) should be avoided. If missed dose founded, then patients should be consulting with doctor specialized in oncologist Regulate the usual dosing schedule.

OVER DOSAGE

Over dosage of Lenalid 10mg(lenalidomide ) will cause neutropenia & thrombocytopenia as mainly common side effects. Give the patient general supportive treatment. check the blood cells counts regularily during the treatment.

SIDE EFFECTS

Second primary malignancies :
Hepatotoxicity , Hypersensitivity reactions, Thyroid dysfunction, Fetal toxicity, Hematological toxicity, Tumor lysis syndrome, Tumor flare reactions, Increase of mortality rate.
Common side effects;
Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Fatigue, Asthenia, Pyrexia, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout.

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