applepharmaceutical@gmail.com
drug

PRODUCT DETAILS

Brand name : Lenangio
Strength : 25mg
Active substance : Lenalidomide
Manufactured by :Dr. Reddy’s laboratories
Pack : 10 capsules in a strip
Category : Anti-neoplastic drug

for MORE INFORMATION !!!

Lenangio 25mg is belongs to anticancer medication which contains Lenalidomide as an active substance which belongs to thalidomide analogue.
Lenangio 25mg is used to the disease condition by combining with dexamethasone.
Lenangio 25mg consist of some other pharmacological activities like immuno modulatory & anti-angiogenesis.
Lenangio 25mg is a prescription drug that can only use under the supervision of medical oncologist.

INDICATION

The indications of Lenangio 25mg are;
Lenangio combination with dexamethasone is indicated to treat the patients suffered from multiple myeloma
Lenangio is indicated for the patients having transfusion-dependent anemia because of intermediate 1 risk myelodysplastic syndrome along with deletion 5q cytogenetic abnormality without or without addition cytogenetic abnormalities
Lenangio is used to treat the patients with mantle cell lymphoma in which its used whose the disease was relapsed or progressed after two before treatment, especially the disease not response with the bortezomib therapy.

The adult usual dose of Lenangio 25mg in myelodysplastic syndromes is 10mg and administrated once a day.
For renal damaged patients;
CrCl >60ml/min In Patients should not needed dosage adjustment of Lenangio
CrCl 30 to 60ml/min In Patients, 5mg of Lenangio should administer orally as once daily
CrCl <30ml/min In Patient, 2.5mg of Lenangio should be given orally as a once daily.
Dosage variation;
Thrombocytopenia:
Drops to <50000/mcL, treatment should be interrupted. Back to > or equal to 50000/mcL, follow the Lenangio of 5mg per day.
Neutropenia;
Drops to <500/mcL, treatment should be delayed. Back to > or equal to 500/mcL, treatment should be follow to 5mg per day.
Multiple myeloma;
In this disease, concomitant use of dexamethasone with Lenangio. The regular dose of Lenangio is 25mg should be given as once in a day on day 1 to 21.
The dose of dexamethasone;
Dexamethasone 40mg should be continued on day 1 to 4, 9 to 12 & 17 to 20 of each period of 28-day cycles. Patient with greater than 75 years, dexamethasone 20mg should be prescribed on day 1, 8, 15, & 22.
Mantle cell lymphoma;
The usual dose of Lenangio for this disease is 25mg should be given orally as once daily.
For renal damaged patients;
CrCl 30 to 60ml/min in patient, Lenangio 10mg should be given as once daily. CrCl <30ml/min in patients, Lenangio 15mg should be used for q48hr.
Pediatrics;
The safety & efficiency of Lenalidomide has not been described in pediatric patients with age of <18 years.

MECHANISM

Lenangio 25mg involves in the prudence of tumor and factor alpha arrangement, that reinforcement the T-cells and leads to lessening plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast growth factor.
Lenangio 25mg is moreover engaged with the stave off angiogenesis.
Lenalidomide is furthermore authorize G1 cell cycle capture and apoptosis of ruinous cells.

PHARMACOKINETICS

Absorption:
Absorbed rapidly with peak plasma concentration is between 0.625 and 1.5 hrs. combining with food will not change the prolong of absorption but dose decrease in Cmax.
Distribution:
Bounding of plasma protein is 30%
Metabolism:
Mainly metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide.
Excretion:
Primarily eliminated in renal route and the dose excreted via urine 90% and feces 4% and half-life is 3hrs

DRUG INTERACTION

Interaction of Lenangio 25mg with digoxin leads to increased concentration of digoxin causes increased risk of adverse effects related to digoxin.
Interaction of Lenangio 25mg with Erythropoietic agents, cause to produced rises in risk of thrombosis. Discuss with the patients prior to starting this combination treatment.
Interaction of Lenangio 25mg with warfarin, will produce increased exposure of hemorrhage disorders. check the INR value & prothrombin time.

CONTRAINDICATION

When pregnancy period the drug is contraindicated The patients are contraindicated to hypersensitivity reaction and the Lenangio 25mg component.

OVER DOSAGE

Over dosage of Lenangio 25mg will cause neutropenia & thrombocytopenia as mainly common side effects. Give the patient general supportive treatment. check the blood cells counts regularly during the treatment.

MISSED DOSE

The missed dose of Lenangio 25mg should be avoided. If missed dose founded, then patients should be consulting with doctor specialized in oncologist Regulate the usual dosing schedule.

SIDE EFFECTS

Second primary malignancies Hepatotoxicity , Hypersensitivity reactions, Thyroid dysfunction, Fetal toxicity, Hematological toxicity, Tumor lysis syndrome, Tumor flare reactions, Increase of mortality rate.
Common side effects;
Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Fatigue, Asthenia, Pyrexia, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout.

WARNING

The some of the common life-threatening condition like :
Venous & arterial thromboembolism
Blood clotting effects
Embryo fetal damage
Hypersensitivity reactions
Hematological disorders
For all these conditions, some supportive measures should be used and provide safety measures.

We'd Like to Hear From You!

PRESCRIPTION POLICY

1. myapplepharma.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. myapplepharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the myapplepharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. myapplepharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from myapplepharma.com.
6. At myapplepharma.com, a Caregiver can order prescription medicines on your behalf.


This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.