applepharmaceutical@gmail.com
drug

PRODUCT DETAILS

Brand name : Mabtas RA
Composition : Rituximab
Strength : 100mg
Manufactured by : Intas Pharma
Dosage form : injection

for MORE INFORMATION !!!

Mabtas RA 500mg is an anticancer medicine which prevents the growth and spread of cancer cells in the body.
Mabtas RA 500mg will help to prevent the Non- Hodgkin’s lymphoma or chronic lymphocytic and with combination with another anticancer drug like methotrexate is used for rheumatoid arthritis symptoms in adult treatment.
Mabtas RA 500mg with steroid regimen combination is given for the treatment of some rare disorders which cause blood vessels and other tissues inflammation in the body.

INDICATIONS

Mabtas RA 500mg and hyaluronidase human injection are given alone or combination with otherdrugs to treat certain types of non-Hodgkin's lymphoma and chronic lymphocytic leukemia (cancer start in WBC).
Mabtas RA 500mg injection combination with methotrexate (Otrexup, Rasuvo, Xatmep, others) is also indicated for the treatment rheumatoid arthritis symptoms in adults that have been already treated with a some type of regimen knowns as tumor necrosis factor (TNF) inhibitor. Mabtas RA 500mg is a type in a classification of drugs called monoclonal antibodies.
Mabtas RA 500mg is used to killing cancer cells to treat NHL , CLL, rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis by inhibiting the activity of the immune system parts that can injury the joints, veins, and other blood vessels and cause organs (heart and lungs) damage.

DOSAGE

Mabtas RA injection is usually used to administrate only via intravenous infusion not by IV push or bolus.
Before Each Infusion the Drug Is Premediate :
First infusion:
Starting treatment rate of 50 mg/hr. is administer, in not showing infusion toxicity, rate raised up to 50 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.
Successive infusion:
initial at rate of 100 mg/hr., in not showing infusion toxicity, rate raised up to 100 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.
While combination with CHOP chemotherapy the injection Mabtas RA has not been given. Hence Premedication with corticosteroids must be considered.
Low grade or follicular non-Hodgkin’s lymphoma:
The drug Dose is 375 mg/m2 as an IV infusion.
Once weeks for 4 or 8 doses administrated for Relapsed treatment
Once weekly for 4 doses administrated for Retreatment for relapsed.
Previously untreated:
administer on day 1 of each cycle of chemotherapy, up to 8 doses. In complete or partial response of patient, start with 8 weeks for maintenance following Mabtas RA 500mg in combination with chemotherapy completed then administer 8weeks for 12 doses as a single agent.
Once weekly for 4 doses at intervals of 6 months and max of 16 doses for Non – progression (following CVP chemotherapy completion 6 – 8 cycles):
On day 1 each cycle of chemotherapy up to 8 infusions for Diffuse Large B- cell NHL
Chronic Lymphocytic Leukemia :
Before starting of FC chemotherapy, dose recommended is 375 mg/m2 followed 500 mg/m2 on day 1 of 2-6 cycles every 28 days.
Component of Zevalin for treatment of NHL:
The dose 250 mg/m2 of Mabtas RA injection within 4 hours prior to the administration of Indium-111-(In-111-) Zevalin and Yttrium-90- (Y-90-) Zevalin.
7–9 days before to Rituxan and Y-90- Zevalin administrate Rituxan and In-111-Zevalin.

Rheumatoid Arthritis:
When combination of Mabtas RA injection with methotrexate is administrated.
Mabtas RAinjection given as two doses of 100mg IV infusion 2 weeks separated.
When glucocorticoids administered as methylprednisolone 100mg IV
Subsequent course based on clinical evaluation must administer every 24 weeks, but not early than every 16 weeks.
Granulomatosis Polyangiitis And Microscopic Polyangiitis :
Mabtas RA injection administer Dose of 375 mg/m2 IV infusion weekly once for 4 weeks.
When Glucocorticoids given with methylprednisolone by dose of 1000 mg IV/ day for 1- 3 days and purse by oral prednisone 1 mg/kg/day are recommended for the treatment of symptoms of serious vacuities This drug should initiate within 14 days before or with the starting of Mabtas RAinjection and may continue during and after the 4-week course with treatment of Mabtas RAinjection drug.
Safety and not established for subsequent infusion.
ADMINISTRTION :
Take an amount Mabtas RAinjection is administer and diluted to final concentration of 1 mg/ml up to 4 mg/ml as infusion (containing either 0.9% Nacl or 5% dextrose in water). Gently Invert the bag and mix the solution. Discard unused drug left in vial.
OVERDOSAGE:
If over dose occurs seek immediately to the emergency department or poison control help line.
please consult the doctor for further clarification.

PHARMACOKINETICS

Absorption:
Not available
Distribution:
volume of distribution is 3.1 L There is no human plasma level
Metabolism:
Mabtas RA 500mg metabolized by human antimurine antibody production.
Elimination :
not available The drug elimination of half-life of NHL is 22 days and for RA is 18.0 days, GPA and microscopic polyangiitis is 23 days.

MECHANISM OF ACTION

Mabtas RA 500mg is a type of class called as monoclonal antibody. A new type of "targeted" cancer treatment and an integral part of the body's immune system. Naturally the body fused to antibodies in along with an antigen which has entered the body and attack the antigen for destruction by the immune system.
Monoclonal antibiotics which only targeted by an essential cell only, they may cause less toxicity to healthy cell and it is prescribed treatment given only for cancers in which antigens (and the respective antibodies) have been already identified.
Mabtas RAinjection works by linking to the CD20 antigen on normal and malignant B-cells. Hence natural immune security of body are initiated to attach and kill the marked B-cells. Young cells (stem cells) in the bone marrow which will develop into the various cell types and do not have the CD20 antigen. After treatment CD20 antigen allows healthy B-cells to multiply.

PRECAUTIONS

Allergic condition against Mabtas RA 500mg or any other medication inform your doctor. Information about past medical history used which include in prescription, non-prescription, vitamins &supplements, nutritional products just inform the doctor.
While using Mabtas RA 500mg do not take any vaccination or immunization without taking advice from doctors.
Avoid use of Mabtas RA 500mg if you are pregnant. It will harm the baby unborn, while using Mabtas RA 500mguse correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Mabtas RA 500mg may affect the ability to have children in women. Inform your doctor if you planning to pregnant.
It is unknown whether Mabtas RA 500mg passes into breast milk, avoid breast-feed while on Mabtas RA 500mg treatment.

STORAGE

Store the drug at 2℃ – 3℃
Keep away from the childerns
Use the drug before expiry date
Protected from direct sunlight and Do not freeze or shake.
Discard the unused drug by asking the advice from doctor or pharmacist.

DRUG INTERACTION

Mabtas RA 500mg drug interaction has limited data is available at present.
Interaction with fludarabine or cyclophosphamide have no effects in pharmacokinetics in CLL patients.
Mabtas RA combination with methotrexate had no effects in pharmacokinetics.

CONTRAINDICATION

Hypersensitivity or murine proteins.
Active severe infections in rheumatoid arthritis
Uncontrolled cardiac disease.

MISSED DOSE

If a dose missed then have the drug soon you remembered, if next dose time reach then leave the missed dose and follow the normal schedule.
Do not have 2 doses at a same time. Please consult with doctor for further details.

SIDE EFFECTS

Common effects: fever and chills (flu lik symptoms)
Less common side effects: Weakness; nausea ; headache; cough ; dyspnea ; pharyngitis.

We'd Like to Hear From You!

PRESCRIPTION POLICY

1. myapplepharma.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. myapplepharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the myapplepharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. myapplepharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from myapplepharma.com.
6. At myapplepharma.com, a Caregiver can order prescription medicines on your behalf.


This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.