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Naivex-50mg

PRODUCT DETAILS

Trade name : Naivex
Active ingredient :Dolutegravir
Strength availability : 50MG
Manufactured by : Hetero healthcare
Package : 30 tablets in a container
Category : Anti-retroviral drugs

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Naivex is additionally against retro viral medication, including Dolutegravir as a functioning part. Naivex ought not to be utilized alone; it might consolidate with other hostile to retroviral operators for better action against HIV-1 diseases. Naivex aren’t curing the HIV-1 disease, however used to control the quantity of HIV tallies in the body, and preclude HIV serious sick known as AIDS.

PHARMACOLOGICAl CATRGORY

Both are hostile to retroviral prescription Naivex: Integrase strand exchange inhibitor (Integrase is a protein in charge of exchanging HIV hereditary material into human chromosome causes creation)

WORKS AS

Naivex (Dolutegravir) contains contradicting to viral property against HIV make I sullying. Naivex is stated as an Integrase inhibitor, which can counterpart to decrease HIV cell change by interceding with Integrase accomplish to the aggressive site and blockade of strands trade step happened. The viral DNA mix into have cells get stopped This trade procedure is accountable for HIV cell increment cycle. This prompts impediment of viral development

DOSAGE

Patients creatinine freedom, urine protein, urine glucose ought to be observed occasionally. Naivex: Comprising of 50mg of Dolutegravir

The dosage recommendation of Naivex

The standard endorsed dosage of both the product is one tablet ought to be directed orally as a single dosage. Naivex ought to be taken with or without meal. Naivex ought to have the capacity to take in adults patients and pediatric having body weight of no less than 35kg

PHARMACOKINETICS

Absorption:
Greatest plasma concentration time of Dolutegravir is 2 to 3 hours .The persistent state level reaches inside 5 days
Distribution:
Dolutegravir is largely bound to human plasma protein at 98.9%
Metabolism:
The metabolism of Dolutegravir is happens through UGT1A1 with some extra commitment from CYP3A.
Elimination:
The terminal half existence of Dolutegravir is 14 hours. The significant course of disposal is urine and as an unaltered frame through feces.

Recommendation for Naivex

In pediatric :
The suggested dosage of Naivex for 30 to less than 40kg patients: 35mg should be taken as a once a day orally For 40kg or greater patients: The prescribed dosage is 50mg once daily should be administered orally. In adults: INSTI (Integrase strand transfer inhibitor)
For new patients or experienced INSTI new or virologically restrained :
The prescribed dose of Naivex in this condition is 50mg should be taken as once a day
For new or experienced INSTI new by combining with UGT1A or CYP3A inducers :
The prescribed dose of Naivex is 50mg should be given as two times a day
The prescribed dose of Naivex is 50mg should be given as two times a day :
The prescribed dose of Naivex is 50mg should be given as two times a day
over dose :
There is no uncommon neutralizing agent is favored for over dosage of Naivex, in light of the way that Dolutegravir is exceptionally bound to human plasma protein.

DRUG INTERACTION

Naivex joins with drugs released through OCT2 or MATE1 (dofetilide or metformin), causes elongation of plasma concentration of these medicines. Naivex joined with etravirine causes lessen in plasma dissemination of Dolutegravir. Naivex at the same time used with threatening to mycobacterials, against convulsants or herbal product like st. Johns wort causes depletion in plasma dissemination of Dolutegravir. Dolutegravir is a substrate of UGT1A3, UGT1A9, BCRP and P-gp transporters. Naivex joined with the prescription which prohibits these synthetic compounds or transporters cause, growing the plasma concentration of Dolutegravir. Naivex tablets is specialist use with non-nucleoside reverse transcriptase inhibitors; causing utilization of effect of union of Naivex. If Naivex tablets are solidifies with protease inhibitor causes decreasing in plasma appropriation of Dolutegravir.

SAFETY MEASURES

An anaphylactic response: This may happen as a result of contraindication
Nonappearance of virological response due to drug interaction: The Resistance of Naivex may occur in a patient in the midst of going with use other drugs.
Safe reconstitution issue: Some sheltered modifying illness is occurred in the midst of the fundamental period of threatening to retro viral treatment
Safe reconstitution issue: Some sheltered modifying illness is occurred in the midst of the fundamental period of threatening to retro viral treatment

MISSED DOSE

Naivex, are unfriendly to retroviral prescription, if missed measurements occurred over the traverse of treatment, must be direct with therapeutic master and take after the rule as indicated by their suggestion. On the other way, the missed dose should be avoided and take the standard schedule.

PREGNANCY

The pregnancy classification of Dolutegravir is B .Using Naivex in pregnancy condition with caution, essentially in the wake of knowing the danger parts to the hatchling of these things.In Some patients placental change happens, in such conditions stop the utilization of these products.

PEDIATRIC

In body weight of the pediatric patients no less than 35kg, hostile to retro viral treatment is relevant. In the body weight of under 25kg: The strength of the Naivex ought not to be evaluated.

STORAGE

Naivex container should be kept at 25℃, protect the container away from light, moisture & heat.

SIDE EFFECTS

The adverse effects occur in this therapy; Liver toxicity Anaphylactic reactions Immune reconstitution syndrome

The most common side effects like; Insomnia Neutrophils elevation Increase in lipase Anxiety Depression Creatine kinase elevation

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